Results 101 to 110 of about 20,732 (256)

A novel treatment of cystic fibrosis acting on-target:cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR [PDF]

, 2016
We previously reported that the combination of two safe proteostasis regulators, cysteamine and epigallocatechin gallate (EGCG), can be used to improve deficient expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in patients ...
A Di Pasqua, A Luciani, A Luciani, A Mehta, A Sepe, A Tosco, A Venerando, AM Cantin, AM Jones, AMP Boyle, AS Verkman, B Bosch, B Illek, BW Ramsey, C A Leone, CE Wainwright, D Bilton, D De Stefano, D De Stefano, D Taylor-Robinson, DM Cholon, E Ferrari, F De Gregorio, F Emma, F Munkonge, F Ratjen, FJ Accurso, G Bona, G De Rosa, G Kroemer, G Stoll, G Veit, H Abdi, H Amano, H Corvol, H Fischer, I Sana, JH vanDoorninck, JL Jameson, JN Snouwaert, K De Boeck, K De Boeck, L Maiuri, L Maiuri, L Salvadori, LL Vanscoy, M C Maiuri, M Stern, MD Amaral, MD Amaral, MK Mansoura, ML DeMarco, NJ Schork, NT Awatade, P Buonpensiero, PB Davis, R Grassia, R Paine, RR Marchelletta, S Esposito, S Guido, S Jayaraman, S Lusa, V Gondzik, V Raia, VR Villella, WA Gahl, X Qu, X Wang   +68 more
core   +4 more sources

Tuning Covalent Organic Frameworks via Nucleophilic Aromatic Substitution

Small Science, Volume 6, Issue 3, March 2026.
The direct nucleophilic aromatic substitution reaction on a fluorinated covalent organic framework leads to functional materials bearing bulky pendant groups such as carbazole or ferrocene. The method is versatile, suitable for O‐, S‐, and N‐based nucleophiles, and provides a unique conjugated structure containing electron‐withdrawing fluorine atoms ...
Óscar González‐Rosell, David Reyes‐Mesa, Albert Gallego‐Gamo, Roc Matheu, Elies Molins, Roser Pleixats, Adelina Vallribera, Albert Granados, Carolina Gimbert‐Suriñach   +8 more
wiley   +1 more source

Influence of supplemented coated-cysteamine on morphology, apoptosis and oxidative stress status of gastrointestinal tract

BMC Veterinary Research, 2019
Background Cysteamine was coated to cover its odor and maintain the stability. However, coated cysteamine (CC) has not been clearly evaluated for its effects on the gastrointestinal mucosa status. We hypothesize that the appropriate CC supplementation in
Hongnan Liu, Miaomiao Bai, Bie Tan, Kang Xu, Rong Yu, Ruilin Huang, Yulong Yin   +6 more
doaj   +1 more source

Detecting patchy nanoparticle assembly at the single-particle level [PDF]

, 2017
Patchy colloidal particles offer a unique platform to explore and investigate spatially inhomogeneous colloidal interactions. In the present work we provide direct, in situ experimental observation at the single particle level on the colloidal ...
Deák, András, Hajnal, Zoltán, Pothorszky, Szilárd László, Szekrényes, Dániel, Zámbó, Dániel   +4 more
core   +1 more source

A New and Rapid LC-MS/MS Method for the Determination of Cysteamine Plasma Levels in Cystinosis Patients

Pharmaceuticals
Cystinosis is a rare lysosomal storage disorder caused by autosomal recessive mutations in the CTNS gene that encodes for the cystine transporter cystinosin, which is expressed on the lysosomal membrane mediating the efflux of cystine.
Raffaele Simeoli, Sara Cairoli, Marcella Greco, Francesco Bellomo, Alessandro Mancini, Chiara Rossi, Carlo Dionisi Vici, Francesco Emma, Bianca Maria Goffredo   +8 more
doaj   +1 more source

Mediator-free total cholesterol estimation using a bi-enzyme functionalized nanostructured gold electrode [PDF]

, 2015
We report the fabrication of a bi-enzyme functionalized nanostructured Au electrode for the mediator-free determination of total cholesterol. A one-step electrochemical route for the synthesis, functionalization and deposition of Au nanostructures via ...
Agrawal, Ved Varun, Sharma, Rachna, Sinha, R. K.   +2 more
core  

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT(3)) receptors ...
Aapro, Ahern, Amy Alexander, Andrew J. Samson, Bearcroft, Bertrand, Bertrand, Bhattacharyya, Boyd, Chanrion, Chen, Chen, Christopher Moffat, Christopher N. Connolly, Connolly, Craig, Faerber, Freeman, Galligan, Guthrie, Hagbom, Hanley, Hansen, Hothersall, Huang, Ilegems, J. Daniel Hothersall, Jiménez-Trejo, Karen A. Bollan, Kittler, Kondaurova, Lau, Lee, Linder, Liu, Liu, Lummis, McKinnon, Mercado, Minami, Mnie-Filali, Muchatuta, Niesler, Riad, Rojas, Schlag, Spiller, Stratz, Tao-Cheng, Turvill, Vikenes, Wade, Wesseldijk, Whalen, Yasuda   +54 more
core   +3 more sources

ヒラメおよびコイのタウリン合成能およびその合成経路に関する基礎的研究 [PDF]

, 2019
東京海洋大学博士学位論文 平成29年度(2017) 応用生命科学 課程博士 甲第503号指導教員 ...
Gonzales Maria Mojena Gallo
core   +1 more source

Adherence to Cysteamine Therapy Among Patients Diagnosed with Cystinosis in Saudi Arabia: A Prospective Cohort Study

Pharmacy
Cystinosis is a rare autosomal recessive disorder in which cystine crystals accumulate within the cellular lysosomes, causing damage to multiple organs.
Reem Algasem, Nedaa Zainy, Essam Alsabban, Hamad Almojalli, Khalid Alhasan, Tariq Ali, Deiter Broering, Hassan Aleid   +7 more
doaj   +1 more source

Modification of Poly(5,6-epoxy-l-norleucine) Gives Functional Polypeptides with Alternative Side-Chain Linkages. [PDF]

, 2020
The preparation and characterization of a new epoxide containing polypeptide, poly(5,6-epoxy-l-norleucine), via postpolymerization modification of poly(l-homoallylglycine) is described.
Deming, Timothy J, Perlin, Pesach, Scott, Wendell A   +2 more
core