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Radiation Protection of Tissue Culture Cells by Anoxia, Cysteamine and a Combination of Anoxia and Cysteamine [PDF]

Nature, 1962
Evidence is given in support of the hypothesis that the radioprotective action of a group of sulfhydryl compounds such as cysteine and cysteamine is not based on the removal of oxygen but is caused by another mode of action on the cellular level. In the experiments, cysteamine in concentrations of 4 and 16 mM- bar gave dose reduction factors of 1.8 and
O. Vos, L. Budke, A.J. Vergroesen
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Cysteamine and cystamine

1987
Publisher Summary This chapter discusses about cysteamine and cystamine. Cysteamine (2-aminoethanethiol) is formed in mammalian tissues by the enzymatic hydrolysis of pantetheine, and has the role in the biosynthesis of hypotaurine. Cysteamine has been used therapeutically to treat cystinosis and sickle cell anemia, and has been used as a protective ...
Michael W. Duffel, Daniel J. Logan, Daniel M. Ziegler   +2 more
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Treatment of cystinosis with cysteamine

The Journal of Pediatrics, 1979
C v s T I N 0 S I S is a recessively inherited metabolic disorder characterized by an accumulation of nonprotein cystine within the lysosomes. 1 ! n the juvenile nephropathic form, the disease presents with tubular renal dysfunction and progressive glomerular damage, leading to end-stage renal failure and eventual death.
M.S. DeWolfe, J.F.S. Crocker, E.P. Girardin   +2 more
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Cysteamine Toxicity in Patients with Cystinosis

The Journal of Pediatrics, 2011
To report new adverse effects of cysteamine.Detailed clinical information was obtained from the patients' physicians.New adverse events were reported in 8 of 550 patients with cystinosis treated with cysteamine in Europe during the last 5 years. Detailed clinical information was not available for 2 of these patients, 1 of whom died from cerebral ...
Besouw, M.T., Bowker, R., Dutertre, J.P., Emma, F., Gahl, W.A., Greco, M., Lilien, M.R., McKiernan, J., Nobili, F., Schneider, J.A., Skovby, F., van den Heuvel, L.P., van den Heuvel, L.P., van 't Hoff, W.G., Levtchenko, E.N.   +14 more
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Metal Content of Cysteamine Oxygenase

European Journal of Biochemistry, 1968
Cysteamine oxygenase has been analysed for the presence of metals, by spectrographic analysis, and X‐ray fluorescence. Iron, copper, and zinc have been found in the enzyme in the quantity accounting for 1 atom of each metal per molecule of enzyme.Passage of the enzyme through a chelating resin column did not appreciable change the specific activity but
F. Cotta-Ramusino, M.T. Graziani, Roberto Scandurra, Doriano Cavallini, Silvestro Duprè   +4 more
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Mechanism of the protective action of cysteamine in frozen aqueous solutions of DNA and cysteamine

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1972
1. Cysteamine (CA) radicals of the RS type are recorded instead of radicals with the thymine (TH) structure, observed in DNA solutions, when an aqueous frozen solution of DNA and CA, irradiated at 77°K, is warmed up. 2. The formation of RS is explained by transfer of H from CA to the DNA macroradical and by a process which includes ...
M. N. Sultankhodzhaeva, V.A. Sharpatyi
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Cysteamine assay for the evaluation of bioactive electrophiles

Free Radical Biology and Medicine, 2021
Covalent modifications of thiol and amine groups may control the function of proteins involved in the regulatory and signaling pathways of the cell. In this study, we developed a simple cysteamine assay which can be used to study the reactivity of electrophilic compounds towards primary amine and thiol groups in an aqueous environment.
Krzysztof Stolarczyk, Lenka Roubalová, Vlastimil Dorčák, Jan Vacek, Jan Vacek, Jiří Vrba, David Novak, Martina Zatloukalová   +7 more
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Adrenergic blocking action of cysteamine

Experientia, 1962
Il a ete demontre que la cysteamine provoque une activation centrale adrenergique accompagnee par une liberation des catecholamines de la surrenale. Plus tard cet effet est suivi par un blocage periferique des recepteurs adrenergiques.
J. Davidović, R. Debijadji, S. Elcić, V. Varagić   +3 more
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Cysteamine

Drug Discovery Today, 2013
Cysteamine is an amino thiol with the chemical formula HSCH2CH2NH2. Endogenously, cysteamine is derived from coenzyme A degradation, although its plasma concentrations are low. Most experience with cysteamine as a drug originates from the field of the orphan disease cystinosis, in which cysteamine is prescribed to decrease intralysosomal cystine ...
Besouw, Martine, Masereeuw, R., van den Heuvel, Lambert, Levtchenko, Elena   +3 more
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Cysteamine: an old drug with new potential

Drug Discovery Today, 2013
Cysteamine is an amino thiol with the chemical formula HSCH2CH2NH2. Endogenously, cysteamine is derived from coenzyme A degradation, although its plasma concentrations are low. Most experience with cysteamine as a drug originates from the field of the orphan disease cystinosis, in which cysteamine is prescribed to decrease intralysosomal cystine ...
Lambert P. van den Heuvel, Lambert P. van den Heuvel, Lambert P. van den Heuvel, Rosalinde Masereeuw, Martine T.P. Besouw, Elena Levtchenko, Elena Levtchenko   +6 more
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