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Drug Discovery Today, 2013
Cysteamine is an amino thiol with the chemical formula HSCH2CH2NH2. Endogenously, cysteamine is derived from coenzyme A degradation, although its plasma concentrations are low. Most experience with cysteamine as a drug originates from the field of the orphan disease cystinosis, in which cysteamine is prescribed to decrease intralysosomal cystine ...
Besouw, Martine +3 more
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Cysteamine is an amino thiol with the chemical formula HSCH2CH2NH2. Endogenously, cysteamine is derived from coenzyme A degradation, although its plasma concentrations are low. Most experience with cysteamine as a drug originates from the field of the orphan disease cystinosis, in which cysteamine is prescribed to decrease intralysosomal cystine ...
Besouw, Martine +3 more
openaire +2 more sources
Nature, 1962
Evidence is given in support of the hypothesis that the radioprotective action of a group of sulfhydryl compounds such as cysteine and cysteamine is not based on the removal of oxygen but is caused by another mode of action on the cellular level. In the experiments, cysteamine in concentrations of 4 and 16 mM- bar gave dose reduction factors of 1.8 and
A J, VERGROESEN, O, VOS, L, BUDKE
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Evidence is given in support of the hypothesis that the radioprotective action of a group of sulfhydryl compounds such as cysteine and cysteamine is not based on the removal of oxygen but is caused by another mode of action on the cellular level. In the experiments, cysteamine in concentrations of 4 and 16 mM- bar gave dose reduction factors of 1.8 and
A J, VERGROESEN, O, VOS, L, BUDKE
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Mechanism of the protective action of cysteamine in frozen aqueous solutions of DNA and cysteamine
Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 19721. Cysteamine (CA) radicals of the RS type are recorded instead of radicals with the thymine (TH) structure, observed in DNA solutions, when an aqueous frozen solution of DNA and CA, irradiated at 77°K, is warmed up. 2. The formation of RS is explained by transfer of H from CA to the DNA macroradical and by a process which includes ...
M. N. Sultankhodzhaeva, V. A. Sharpatyi
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Effects of cysteamine on nociception in mice.
Acta pharmacologica Sinica, 2001The present study was carried to study the effects of cysteamine on nociception in mice.The pain assays were the hot plate and the tail flick test.When cysteamine, a drug well known as a somatostatin depletor, was administered 1 and 4 but not 24 h before the tests (hot plate, tail flick), the nociceptive threshold was elevated when the drug was ...
CAPASSO, Anna, A. LOIZZO
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The Journal of Pharmacology and Experimental Therapeutics, 1957
R A, SALVADOR, C, DAVISON, P K, SMITH
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R A, SALVADOR, C, DAVISON, P K, SMITH
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Neurobiological actions of cysteamine.
Federation proceedings, 1985Somatostatin (SS)-related peptides act within discrete brain regions to inhibit adrenal epinephrine (E) secretion, to prevent hypothermia, and to produce hyperthermia. Depletion of brain concentrations of these SS-related peptides using cysteamine (CSH) or central administration of an SS receptor antagonist increases adrenal E secretion and impairs ...
M, Brown +4 more
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