Results 21 to 30 of about 8,396 (186)

Cysteamine Decreases Low‐Density Lipoprotein Oxidation, Causes Regression of Atherosclerosis, and Improves Liver and Muscle Function in Low‐Density Lipoprotein Receptor–Deficient Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background We have shown previously that low‐density lipoprotein (LDL) can be oxidized in the lysosomes of macrophages, that this oxidation can be inhibited by cysteamine, an antioxidant that accumulates in lysosomes, and that this drug decreases ...
Feroz Ahmad, Robert D. Mitchell, Tom Houben, Angela Palo, Tulasi Yadati, Andrew J. Parnell, Ketan Patel, Ronit Shiri‐Sverdlov, David S. Leake   +8 more
doaj   +1 more source

Mechanisms for the Cytotoxicity of Cysteamine [PDF]

Toxicological Sciences, 2001
The major aim of this study was to quantitatively assess the contribution of H2O2 generation to the cytotoxicity induced by cysteamine. Cysteamine produces H2O2 at levels that correlate with its toxicity between 23 and 160 microM. A maximum of 6.9 microM H2O2 is generated by 625 microM cysteamine.
T M, Jeitner, D A, Lawrence
openaire   +2 more sources

Impact of Dietary Supplementation of Cysteamine on Egg Taurine Deposition, Egg Quality, Production Performance and Ovary Development in Laying Hens

Animals, 2023
This study aimed to examine the effect of dietary cysteamine on yolk taurine content in hens during different egg production periods. In Exp. 1, China Agricultural University-3 (CAU-3) hens at the peak stage of egg production (aged 31 wks) were used to ...
Jing Chen, Youli Wang, Zhenhai Tang, Xiaorui Guo, Jianmin Yuan   +4 more
doaj   +1 more source

A new proof of evidence of cysteamine quantification for therapeutic drug monitoring in patients with cystinosis

Orphanet Journal of Rare Diseases, 2022
Background To date, measurement of intracellular cystine is used for the therapeutic monitoring of patients affected by cystinosis in treatment with cysteamine.
Martina Franzin, Silvia Rossetto, Rachele Ruoso, Rossella Del Savio, Gabriele Stocco, Giuliana Decorti, Riccardo Addobbati   +6 more
doaj   +1 more source

Effects of Coated Cysteamine on Oxidative Stress and Inflammation in Weaned Pigs

Animals, 2021
This study aimed to explore the effects of dietary coated cysteamine on oxidative stress and inflammation in diquat-induced weaning pigs. Twenty-four pigs were randomly assigned to three dietary groups with eight replicates: the control (fed base diet ...
Shanshan Wang, Miaomiao Bai, Kang Xu, Yirui Shao, Zhe Yang, Xia Xiong, Ruilin Huang, Yao Li, Hongnan Liu   +8 more
doaj   +1 more source

Effect of cysteamine and 13-cis-retinoic acid on bovine in vitro embryo production [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018
One of the main factors decreasing the success of an in vitro embryo production is oxidative stress-mediated reactive oxygen species resulting in cellular damages.
Abdolreza RANJBAR, Mohammad Amin ESLAMPOUR, Mehran Farhoodi MOGHADAM   +2 more
doaj   +1 more source

Ophthalmic Outcome in a Belgian Cohort of Cystinosis Patients Treated with a Compounded Preparation of Cysteamine Eye Drops: Retrospective Analysis

Ophthalmology and Therapy, 2019
Introduction Treatment of the anterior segment problems in cystinosis is challenging as oral cysteamine is ineffective in the treatment of corneal problems because of its avascular structure.
Freya Peeters, Catherine Cassiman, Karel Van Keer, Elena Levtchenko, Koenraad Veys, Ingele Casteels   +5 more
doaj   +1 more source

Improved method for the preparation of malonyl coenzyme A

Journal of Lipid Research, 1968
Malonyl coenzyme A is synthesized by transacylating S-malonyl-N-decanoyl cysteamine with coenzyme A. A simplified procedure for the preparation of S-malonyl-N-decanoyl cysteamine, using cysteamine as starting material, is described.
Hans Mohrhauer, Kirsten Christiansen, Minerva Gan, Manfred Deubig, Ralph T. Holman   +4 more
doaj   +1 more source

Oral cysteamine as an adjunct treatment in cystic fibrosis pulmonary exacerbations: An exploratory randomized clinical trial.

PLoS ONE, 2020
BackgroundEmerging data suggests a possible role for cysteamine as an adjunct treatment for pulmonary exacerbations of cystic fibrosis (CF) that continue to be a major clinical challenge.
Graham Devereux, Danielle Wrolstad, Stephen J Bourke, Cori L Daines, Simon Doe, Ryan Dougherty, Rose Franco, Alastair Innes, Benjamin T Kopp, Jorge Lascano, Daniel Layish, Gordon MacGregor, Lorna Murray, Daniel Peckham, Vincenzina Lucidi, Emma Lovie, Jennifer Robertson, Douglas J Fraser-Pitt, Deborah A O'Neil   +18 more
doaj   +1 more source

Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages. [PDF]

PLoS ONE, 2017
Members of the Burkholderia cepacia complex are virulent, multi-drug resistant pathogens that survive and replicate intracellularly in patients with cystic fibrosis (CF). We have discovered that B. cenocepacia cannot be cleared from CF macrophages due to
Chandra L Shrestha, Kaivon D Assani, Hannah Rinehardt, Florentina Albastroiu, Shuzhong Zhang, Richard Shell, Amal O Amer, Larry S Schlesinger, Benjamin T Kopp   +8 more
doaj   +1 more source