Results 321 to 330 of about 827,600 (338)
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Cysteine proteinases in chondrosarcomas
Matrix Biology, 2001The aim of the present study was to define the role of cathepsins B, H, K, L and S in the pathogenesis of human chondrosarcomas. For this purpose 40 tumour samples obtained from 12 patients with the diagnosis of conventional chondrosarcoma were systematically investigated for the expression of cathepsin mRNAs by Northern hybridisation, and for ...
Allan J. Aho +5 more
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Inhibitors of Cysteine Proteases
Current Topics in Medicinal Chemistry, 2006The roles of cysteine proteases (CP) as protein degrading and protein processing enzymes both in physiological and pathological processes of mammals are well known. Furthermore, the key roles of CP;s in the life cycles of infectious agents like protozoa and viruses turn them into new important targets for anti-infective drugs.
Tanja Schirmeister +3 more
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2019
Preparation of antibody-drug conjugates (ADCs) with a highly homogeneous drug loading in general requires site-selective conjugation of a cytotoxic payload. Typically, functionality utilized for attachment of the payload is achieved through engineering of suitable chemical handles or by enzymatic modification of the antibody.
João M. Nunes +2 more
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Preparation of antibody-drug conjugates (ADCs) with a highly homogeneous drug loading in general requires site-selective conjugation of a cytotoxic payload. Typically, functionality utilized for attachment of the payload is achieved through engineering of suitable chemical handles or by enzymatic modification of the antibody.
João M. Nunes +2 more
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Progress in Neurobiology, 2020
Cysteine string protein (CSP) was discovered by use of a synapse-specific, monoclonal antibody to screen a cDNA expression library in Drosophila. A vertebrate CSP homolog was later identified and shown to co-purify with synaptic vesicles. CSP-α is now recognized as a membrane constituent of many regulated secretory organelles.
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Cysteine string protein (CSP) was discovered by use of a synapse-specific, monoclonal antibody to screen a cDNA expression library in Drosophila. A vertebrate CSP homolog was later identified and shown to co-purify with synaptic vesicles. CSP-α is now recognized as a membrane constituent of many regulated secretory organelles.
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THE LYSOSOMAL CYSTEINE PROTEASES
Annual Review of Biophysics and Biomolecular Structure, 1999▪ Abstract A significant number of exciting papain-like cysteine protease structures have been determined by crystallographic methods over the last several years. This trove of data allows for an analysis of the structural features that empower these molecules as they efficiently carry out their specialized tasks.
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The interaction of aurothiomalate and cysteine
Biochemical Pharmacology, 1976Abstract Aurothiomalate and cysteine react under appropriate conditions to produce an insoluble complex of aurocysteine. Although alkylation of the SH group of cysteine completely blocks the reaction, the organomercurials have no effect. The results are compared with, and found to be compatible with, the interaction between aurothiomalate and the ...
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Enzymatic oxidation of cysteine-S35 to cysteine sulfinic acid
Archives of Biochemistry and Biophysics, 1955V.M. Doctor, Jorge Awapara
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Cobalt(III) complexes of cysteine and cysteine derivatives
Inorganic Chemistry, 1969Daryle H. Busch, Vipin M. Kothari
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