Results 1 to 10 of about 45,670 (165)

Quantitative determination of D4-cystine in mice using LC-MS/MS and its application to the assessment of pharmacokinetics and bioavailability

Journal of Pharmaceutical Analysis, 2021
Cystine is the primary source material for the synthesis of glutathione. However, the pharmacokinetics and tissue distribution of cystine are largely unknown.
Shuning Li, Zhenyao Lu, Li Jiao, Ran Zhang, Yu Hong, Jiye Aa, Guangji Wang   +6 more
exaly   +3 more sources

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

eLife, 2021
The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, recent studies indicate that mTORC1 can activate the transcription factor ATF4 through mechanisms ...
Margaret E Torrence, Michael R MacArthur, Aaron M Hosios, Alexander J Valvezan, John M Asara, James R Mitchell, Brendan D Manning   +6 more
doaj   +1 more source

Production of recombinant human xCT (SLC7A11) and reconstitution in proteoliposomes for functional studies

Frontiers in Physiology, 2022
The plasma membrane transporter xCT belongs to the SLC7 family and has the physiological role of mediating the exchange of glutamate and cystine across the cell plasma membrane, being crucial for redox control.
Michele Galluccio, Mariafrancesca Scalise, Gilda Pappacoda, Martina Scarpelli, Marcella Bonanomi, Marcella Bonanomi, Daniela Gaglio, Daniela Gaglio, Cesare Indiveri, Cesare Indiveri   +9 more
doaj   +1 more source

Genetic Landscape of Nephropathic Cystinosis in Russian Children

Frontiers in Genetics, 2022
Nephropathic cystinosis is a rare autosomal recessive disorder characterized by amino acid cystine accumulation and caused by biallelic mutations in the CTNS gene.
K. V. Savostyanov, A. A. Pushkov, O. A. Shchagina, V. V. Maltseva, E. A. Suleymanov, I. S. Zhanin, N. N. Mazanova, A. P. Fisenko, P. S. Mishakova, A. V. Polyakov, E. V. Balanovska, R. A. Zinchenko, A. N. Tsygin   +12 more
doaj   +1 more source

Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming

Frontiers in Cell and Developmental Biology, 2021
Among gynecologic malignancies, ovarian cancer is the third most prevalent and the most common cause of death, especially due to diagnosis at an advanced stage together with resistance to therapy.
Sofia C. Nunes, Sofia C. Nunes, Cristiano Ramos, Cristiano Ramos, Inês Santos, Inês Santos, Cindy Mendes, Cindy Mendes, Fernanda Silva, Fernanda Silva, João B. Vicente, Sofia A. Pereira, Ana Félix, Ana Félix, Luís G. Gonçalves, Jacinta Serpa, Jacinta Serpa   +16 more
doaj   +1 more source

Role of Dual Energy CT Scan in Evaluation of the Chemical Composition of Renal Stones [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: For appropriate management of renal stone knowing its composition is important. Laboratory chemical analysis of the stones involves sophisticated techniques.
Sachin Khanduri, Umar Faizan Sagar, Nazia Khan, Nitin Chahar, Shreshtha Jain, Farzan Khan, Anchal Singh, Neha Nagpal   +7 more
doaj   +1 more source

Cysteines and Disulfide Bonds as Structure-Forming Units: Insights From Different Domains of Life and the Potential for Characterization by NMR

Frontiers in Chemistry, 2020
Disulfide bridges establish a fundamental element in the molecular architecture of proteins and peptides which are involved e.g., in basic biological processes or acting as toxins. NMR spectroscopy is one method to characterize the structure of bioactive
Christoph Wiedemann, Amit Kumar, Andras Lang, Oliver Ohlenschläger   +3 more
doaj   +1 more source

Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli. [PDF]

PLoS ONE, 2015
Intracellular thiols like L-cystine and L-cystine play a critical role in the regulation of cellular processes. Here we show that Escherichia coli has two L-cystine transporters, the symporter YdjN and the ATP-binding cassette importer FliY-YecSC.
Iwao Ohtsu, Yusuke Kawano, Marina Suzuki, Susumu Morigasaki, Kyohei Saiki, Shunsuke Yamazaki, Gen Nonaka, Hiroshi Takagi   +7 more
doaj   +1 more source

Biomarkers in Nephropathic Cystinosis: Current and Future Perspectives

Cells, 2022
Early diagnosis and effective therapy are essential for improving the overall prognosis and quality of life of patients with nephropathic cystinosis. The severity of kidney dysfunction and the multi-organ involvement as a consequence of the increased ...
Francesco Emma, Giovanni Montini, Marco Pennesi, Licia Peruzzi, Enrico Verrina, Bianca Maria Goffredo, Fabrizio Canalini, David Cassiman, Silvia Rossi, Elena Levtchenko   +9 more
doaj   +1 more source

Insulin-like Growth Factor 1 and Transforming Growth Factor-β Stimulate Cystine/Glutamate Exchange Activity in Dental Pulp Cells [PDF]

, 2011
Introduction The growth factors insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) are protective to dental pulp cells in culture against the toxicity of the composite materials Durafill VS and Flow Line (Henry Schein Inc, New ...
Alyssa Furey, Asrari, Barthel, Bègue-Kirn, Cabrera, Camargo, Doug Lobner, Duailibi, D’Souza, Fogal, Franco, Furey, Goldberg, Gronthos, Hansen, Hu, Kalyva, Katherine Pauly, Kaur, Keelan, Kim, Kim, Kymberly Fritz, Lobner, Lovschall, Marcato, Nie, Onishi, Pacheco, Paranjpe, Piani, Piattelli, Ricketts, Rutherford, Stanley, Stockton, Tziafas, Tziafas, Ward, Wood   +39 more
core   +2 more sources