Results 1 to 10 of about 19,150 (245)

SLC7A11 as a Gateway of Metabolic Perturbation and Ferroptosis Vulnerability in Cancer

Antioxidants, 2022
SLC7A11 is a cell transmembrane protein composing the light chain of system xc−, transporting extracellular cystine into cells for cysteine production and GSH biosynthesis.
Jong-Lyel Roh, Jaewang Lee, Roh Jong-Lyel   +2 more
exaly   +5 more sources

Downregulation of lncRNA SLC7A11-AS1 decreased the NRF2/SLC7A11 expression and inhibited the progression of colorectal cancer cells [PDF]

PeerJ, 2023
Colorectal cancer (CRC) is ranked as the second leading cause of cancer-related death worldwide. Many abnormally expressed long non-coding RNAs (lncRNAs) in CRC were identified with the development of next-generation sequencing, most functions of which ...
Tian Wang, Si Liang, Yajing Li, Xiyu Wang, Hongjie Wang, Jiguang Guo, Ming Li   +6 more
doaj   +5 more sources

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

Protein and Cell, 2020
The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.
Boyi Gan, Pranavi Koppula, Koppula Pranavi   +2 more
exaly   +2 more sources

SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression

Redox Biology
The changes of inflammation and metabolism are two features in nonalcoholic steatohepatitis (NASH). However, how they interact to regulate NASH progression remains largely unknown.
Xiude Fan, Qin He, Chang He
exaly   +3 more sources

Glial Glutamate Transporter-Mediated Plasticity: System xc-/xCT/SLC7A11 and EAAT1/2 in Brain Diseases

Frontiers in Bioscience-Landmark, 2023
Glial cells play an essential role in the complex function of the nervous system. In particular, astrocytes provide nutritive support for neuronal cells and are involved in regulating synaptic transmission.
Marc Dahlmanns, Jana Katharina Dahlmanns, Nicolai Savaskan, Hans-Herbert Steiner, Eduard Yakubov   +4 more
doaj   +1 more source

Circ_0072008, an oncogene in pancreatic ductal adenocarcinoma, contributes to tumour cell malignant progression and glycolysis by regulating miR-545-3p/SLC7A11 axis

Autoimmunity, 2022
Background The hsa_circRNA_103809 (circ_0072088) has been an emerging tumour regulator in human cancers, and is identified as one most aberrantly expressed circRNA in patients with pancreatic ductal adenocarcinoma (PDAC).
Hui Sun, Fang Liu, Hongqing Zhang
doaj   +1 more source

The Modulatory Effect of Liraglutide on the Expression of GPX4, HO-1 and SLC7A11 Signaling Pathway in Obese Rats [PDF]

Pharmaceutical Sciences
Background: Obesity, a multifaceted metabolic condition, is associated with oxidative stress and disrupted redox homeostasis, leading to ferroptosis and metabolic dysfunction. Liraglutide, a well-known glucagon-like peptide-1 (GLP-1) receptor agonist, is
Mahmood Jameel Saeed, Inam Sameh Arif
doaj   +1 more source

Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma

BMC Molecular and Cell Biology, 2022
Background Chaperonin containing TCP1 subunit 3 (CCT3) acts as an oncogene in cancers, whereas its role and underlying mechanisms in lung adenocarcinoma (LUAD) are poorly understood.
Kun Wang, Jian He, Changling Tu, Hui Xu, Xugang Zhang, Yongchang Lv, Chao Song   +6 more
doaj   +1 more source

Ferroptosis-associated gene SLC7A11 is upregulated in NSCLC and correlated with patient’s poor prognosis: An integrated bioinformatics analysis

Pteridines, 2021
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, which was involved in the progression of malignant tumors including non-small cell lung cancer (NSCLC).
Huang He, Liu Juan, Wu Haiyan, Liu Fang, Zhou Xiaoxi   +4 more
doaj   +1 more source

Inhibiting system xC− and glutathione biosynthesis – a potential Achilles' heel in mutant-p53 cancers

Molecular & Cellular Oncology, 2017
Effective therapeutic strategies to target mutant tumor protein p53 (TP53, best known as p53) cancers remain an unmet medical need. We found that mutant p53 impairs the function of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2, commonly known as ...
Nicholas J. Clemons, David S. Liu, Cuong P. Duong, Wayne A. Phillips   +3 more
doaj   +1 more source