Results 1 to 10 of about 22,908 (159)
SLC7A11, a Potential Therapeutic Target Through Induced Ferroptosis in Colon Adenocarcinoma
Frontiers in Molecular Biosciences, 2022 Background: Ferroptosis induced by SLC7A11 has an important translational value in the treatment of cancers. However, the mechanism of SLC7A11 in the pathogenesis of colon adenocarcinoma (COAD) is rarely studied in detail.Methods: SLC7A11 expression was ...
Xin Cheng +5 more
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SLC7A11 as a Gateway of Metabolic Perturbation and Ferroptosis Vulnerability in Cancer
Antioxidants, 2022 SLC7A11 is a cell transmembrane protein composing the light chain of system xc−, transporting extracellular cystine into cells for cysteine production and GSH biosynthesis.
Jaewang Lee, Jong-Lyel Roh
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Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
Protein and Cell, 2020 The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.
Pranavi Koppula, Boyi Gan
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Clinical and Translational Medicine, 2022 Background Solute carrier family 7 member 11 (SLC7A11) is overexpressed in multiple human tumours and functions as a transporter importing cystine for glutathione biosynthesis.
Li Liu, Nan Huang, Yue Zhang
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TRIM21 accelerates ferroptosis in intervertebral disc degeneration by promoting SLC7A11 ubiquitination and degradation [PDF]
Open Life SciencesIntervertebral disc degeneration (IVDD) is a common cause of chronic low back pain, and ferroptosis – an iron-dependent form of cell death – has been linked to oxidative stress-induced damage in nucleus pulposus cells (NPCs).
Yu Wei, Liu Yong, Zhou Feng
doaj +2 more sources
Redox BiologyThe changes of inflammation and metabolism are two features in nonalcoholic steatohepatitis (NASH). However, how they interact to regulate NASH progression remains largely unknown.
Qin He
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Downregulation of lncRNA SLC7A11-AS1 decreased the NRF2/SLC7A11 expression and inhibited the progression of colorectal cancer cells [PDF]
PeerJ, 2023 Colorectal cancer (CRC) is ranked as the second leading cause of cancer-related death worldwide. Many abnormally expressed long non-coding RNAs (lncRNAs) in CRC were identified with the development of next-generation sequencing, most functions of which ...
Tian Wang +6 more
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Autoimmunity, 2022 Background The hsa_circRNA_103809 (circ_0072088) has been an emerging tumour regulator in human cancers, and is identified as one most aberrantly expressed circRNA in patients with pancreatic ductal adenocarcinoma (PDAC).
Hui Sun, Fang Liu, Hongqing Zhang
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Frontiers in Bioscience-Landmark, 2023 Glial cells play an essential role in the complex function of the nervous system. In particular, astrocytes provide nutritive support for neuronal cells and are involved in regulating synaptic transmission.
Marc Dahlmanns +4 more
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Cancer Cell International, 2023 Background Disulfidptosis and the disulfidptosis-related gene SLC7A11 have recently attracted significant attention for their role in tumorigenesis and tumour management.
Tonghu Liu +9 more
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