SLC7A11 as a Gateway of Metabolic Perturbation and Ferroptosis Vulnerability in Cancer
Antioxidants, 2022 SLC7A11 is a cell transmembrane protein composing the light chain of system xc−, transporting extracellular cystine into cells for cysteine production and GSH biosynthesis.
Jaewang Lee +2 more
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Slc7a11 Modulated by POU2F1 is Involved in Pigmentation in Rabbit [PDF]
International Journal of Molecular Sciences, 2019 Abstract Solute carrier family 7 member 11 (Slc7a11) codes for a cystine/glutamate xCT transporter and can control production of pheomelanin pigment to change fur and skin colors of animals. Previous studies found that the skin expression levels of Slc7a11 varied significantly with the fur colors of the Rex Rabbit.
Shuaishuai Hu, Bohao Zhao, Naisu Yang
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The Role of SLC7A11 in Cancer: Friend or Foe?
Cancers, 2022 SLC7A11 controls the uptake of extracellular cystine in exchange for glutamate at a ratio of 1:1, and it is overexpressed in a variety of tumours. Accumulating evidence has shown that the expression of SLC7A11 is fine-tuned at multiple levels, and plays diverse functional and pharmacological roles in tumours, such as cellular redox homeostasis, cell ...
Suhan Guo, Li Sijia, Sun Runbin
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The amino acid transporter SLC7A11 expression in breast cancer
Cancer Biology & Therapy, 2023 Breast cancer (BC), characterized by its diverse molecular profiles and clinical outcomes, presents a significant challenge in the development of effective therapeutic strategies.
Preyanka Nath +8 more
doaj +5 more sources
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
Protein and Cell, 2020 The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.
Pranavi Koppula +2 more
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Downregulation of lncRNA SLC7A11-AS1 decreased the NRF2/SLC7A11 expression and inhibited the progression of colorectal cancer cells [PDF]
PeerJ, 2023 Colorectal cancer (CRC) is ranked as the second leading cause of cancer-related death worldwide. Many abnormally expressed long non-coding RNAs (lncRNAs) in CRC were identified with the development of next-generation sequencing, most functions of which ...
Tian Wang +6 more
doaj +5 more sources
SLC7A11, a potential immunotherapeutic target in lung adenocarcinoma
Scientific Reports, 2023 SLC7A11 has significant translational value in cancer treatment. However, there are few studies on whether SLC7A11 affects the immune status of lung adenocarcinoma (LUAD).
Qingqing Shan +7 more
doaj +3 more sources
SLC7A11, a Potential Therapeutic Target Through Induced Ferroptosis in Colon Adenocarcinoma
Frontiers in Molecular Biosciences, 2022 Background: Ferroptosis induced by SLC7A11 has an important translational value in the treatment of cancers. However, the mechanism of SLC7A11 in the pathogenesis of colon adenocarcinoma (COAD) is rarely studied in detail.Methods: SLC7A11 expression was ...
Jingyun Xu
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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
Molecular Cell, 2022 IDO1 oxidizes tryptophan (TRP) to generate kynurenine (KYN), the substrate for 1-carbon and NAD metabolism, and is implicated in pro-cancer pathophysiology and infection biology. However, the mechanistic relationships between IDO1 in amino acid depletion versus product generation have remained a longstanding mystery.
Alessandra Fiore +2 more
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The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer [PDF]
Frontiers in Oncology, 2022 SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione synthesis; a process that protects cells from oxidative stress and is, therefore, critical to cell growth, proliferation, and metabolism.
Kathleen E Delgiorno +2 more
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