Results 31 to 40 of about 21,100 (250)

Identification of SLC7A11‐AS1/SLC7A11 pair as a ferroptosis‐related therapeutic target for hepatocellular carcinoma

Journal of Cellular and Molecular Medicine
AbstractHepatocellular carcinoma (HCC), a prevalent malignancy worldwide, poses significant challenges in terms of prognosis, necessitating innovative therapeutic approaches. Ferroptosis offers notable advantages over apoptosis, holding promise as a novel therapeutic approach for HCC complexities. Moreover, while the interaction between long non‐coding
Xiao Yuan, Yida Wang, Sitong Jiao, Huanhuan Gao, Mengqian Zhang, Xin Wang, Xunyu Zhou, Chuanfang Wu, Jinku Bao   +8 more
openaire   +2 more sources

miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes

Journal of Inflammation Research, 2023
Yongquan Chen, Yecheng Deng, Linghua Chen, Ziyao Huang, Yi Yan, Zhaoqi Huang Department of Cardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaoqi Huang, Department of ...
Chen Y, Deng Y, Chen L, Huang Z, Yan Y, Huang Z   +5 more
doaj  

The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi‐omics study

Cancer Medicine, 2021
Background The ferroptosis inhibitory gene Solute carrier family 7 member 11 (SLC7A11) provides a new strategy for anticancer treatment. However, its function in renal cell carcinoma (RCC) remains elusive.
Fangshi Xu, Yibing Guan, Li Xue, Peng Zhang, Mingrui Li, Mei Gao, Tie Chong   +6 more
doaj   +1 more source

Up-Regulation of circEIF6 Contributes to Pancreatic Cancer Development Through Targeting miR-557/SLC7A11/PI3K/AKT Signaling

Cancer Management and Research, 2021
Tiequan Zhang, Mi Li, Haofeng Lu, Tao Peng Department of Hepatobiliary Surgery, The First People’s Hospital of Jingzhou, Jingzhou 434000, People’s Republic of ChinaCorrespondence: Tiequan ZhangDepartment of Hepatobiliary Surgery, The First ...
Zhang T, Li M, Lu H, Peng T
doaj  

Intra-Tumoral Expression of SLC7A11 Is Associated with Immune Microenvironment, Drug Resistance, and Prognosis in Cancers: A Pan-Cancer Analysis

Frontiers in Genetics, 2021
While many anti-cancer modalities have shown potent efficacy in clinical practices, cancer prevention, timely detection, and effective treatment are still challenging.
Jiajun He, Hongjian Ding, Huaqing Li, Zhiyu Pan, Qian Chen   +4 more
doaj   +1 more source

SLC7A11 promotes EMT and metastasis in invasive pituitary neuroendocrine tumors by activating the PI3K/AKT signaling pathway

Endocrine Connections
Invasive pituitary neuroendocrine tumors (PitNETs) are the most prevalent types of intracranial and neuroendocrine tumors. Their aggressive growth and difficulty in complete resection result in a high recurrence rate.
Shikai Gui, Wanli Yu, Jiabao Xie, Lunshan Peng, Yuanyuan Xiong, Zhen Song, Haitao Luo, Juexian Xiao, Shengtao Yuan, Zujue Cheng   +9 more
doaj   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple-Negative Breast Cancer. [PDF]

Adv Sci (Weinh)
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Lai ZH, Wang Y, Li NN, Zeng L, Liu R, Li X, Li C, Ma XY, Fu W, Tang Y, Chen J, Liao N, Luo ML.   +12 more
europepmc   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Correlations of P53, SLC7A11, CD3+ T cells, and CD8+ T cells with pathological features and prognosis in endometrial carcinoma: Insights from an Asian cohort [PDF]

Journal of Medical Biochemistry
Background: This study investigates the clinical significance of Solute Carrier Family 7 Member 11 (SLC7A11), Tumor Protein p53 (p53), c D3+ T cells, and CD8+ T cells in endometrial carcinoma (EC). By evaluating their expression patterns and correlations
Lv Yuanjie, Zhou Weiwei, Zhang Jingyu, Feng Jing, Xing Rongge, Miao Zhigang   +5 more
doaj   +1 more source

SLC7A11 is an unconventional H+ transporter in lysosomes

Cell
Lysosomes maintain an acidic pH of 4.5-5.0, optimal for macromolecular degradation. Whereas proton influx is produced by a V-type H+ ATPase, proton efflux is mediated by a fast H+ leak through TMEM175 channels, as well as an unidentified slow pathway. A candidate screen on an orphan lysosome membrane protein (OLMP) library enabled us to discover that ...
Nan Zhou, Jingzhi Chen, Meiqin Hu, Na Wen, Weijie Cai, Ping Li, Liding Zhao, Yaping Meng, Dongdong Zhao, Xiaotong Yang, Siyu Liu, Fangqian Huang, Cheng Zhao, Xinghua Feng, Zikai Jiang, Enjun Xie, Hongxu Pan, Zhidong Cen, Xinhui Chen, Wei Luo, Beisha Tang, Junxia Min, Fudi Wang, Junsheng Yang, Haoxing Xu   +24 more
openaire   +2 more sources