Results 31 to 40 of about 23,034 (273)

Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed

Journal of Comparative Neurology, 2015
ABSTRACTThe cystine/glutamate antiporter or system exchanges cystine for glutamate, thereby supporting intracellular glutathione synthesis and nonvesicular glutamate release. The role of system in neurological disorders can be dual and remains a matter of debate. One important reason for the contradictory findings that have been reported to date is
Van Liefferinge, Joeri, Bentea, Eduard, Demuyser, Thomas, Albertini, Giulia, Follin-Arbelet, Virginie, Holmseth, Silvia, Merckx, Ellen, Hideyo, Sato, Aerts, Joeri L, Smolders, Ilse, Arckens, Lutgarde, Danbolt, Niels C, Massie, Ann   +12 more
openaire   +3 more sources

SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production

Frontiers in Cell and Developmental Biology, 2021
In age-related macular degeneration (AMD), one of the principal sources of vascular endothelial growth factor (VEGF) is retinal pigment epithelium (RPE) cells under hypoxia or oxidative stress. Solute carrier family 7 member 11 (SLC7A11), a key component
Xiaohuan Zhao, Xiaohuan Zhao, Xiaohuan Zhao, Xiaohuan Zhao, Min Gao, Min Gao, Min Gao, Min Gao, Jian Liang, Jian Liang, Jian Liang, Jian Liang, Yuhong Chen, Yuhong Chen, Yuhong Chen, Yuhong Chen, Yimin Wang, Yimin Wang, Yimin Wang, Yimin Wang, Yuwei Wang, Yuwei Wang, Yuwei Wang, Yuwei Wang, Yushu Xiao, Yushu Xiao, Yushu Xiao, Yushu Xiao, Zhenzhen Zhao, Zhenzhen Zhao, Zhenzhen Zhao, Zhenzhen Zhao, Xiaoling Wan, Xiaoling Wan, Xiaoling Wan, Xiaoling Wan, Mei Jiang, Mei Jiang, Mei Jiang, Mei Jiang, Xueting Luo, Xueting Luo, Xueting Luo, Xueting Luo, Feng Wang, Xiaodong Sun, Xiaodong Sun, Xiaodong Sun, Xiaodong Sun   +48 more
doaj   +1 more source

Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study [PDF]

, 2013
Background: Metabolomics helps to identify links between environmental exposures and intermediate biomarkers of disturbed pathways. We previously reported variations in phosphatidylcholines in male smokers compared with non-smokers in a cross-sectional ...
Adamski, Jerzy, Bader, Erik, Dong, Xiao, Holzapfel, Christina, Illig, Thomas, Jaremek, Marta, Ladwig, Karl H, Li, Yixue, Perstorfer, Katrin, Peters, Annette, Prehn, Cornelia, Rathmann, Wolfgang, Roemisch-Margl, Werner, Suhre, Karsten, Theis, Fabian, Wallaschofski, Henri, Wang-Sattler, Rui, Wichmann, H -Erich, Xu, Tao, Yu, Zhonghao   +19 more
core   +3 more sources

Circ_0000140 Alters miR-527/SLC7A11-Mediated Ferroptosis to Influence Oral Squamous Cell Carcinoma Cell Resistance to DDP

Pharmacogenomics and Personalized Medicine, 2023
Yu Ma, Jinbo Gao, Hongning Guo Department of Stomatology, Tianjin Third Central Hospital, Tianjin, People’s Republic of ChinaCorrespondence: Yu Ma, Department of Stomatology, Tianjin Third Central Hospital, No.
Ma Y, Gao J, Guo H
doaj  

The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi‐omics study

Cancer Medicine, 2021
Background The ferroptosis inhibitory gene Solute carrier family 7 member 11 (SLC7A11) provides a new strategy for anticancer treatment. However, its function in renal cell carcinoma (RCC) remains elusive.
Fangshi Xu, Yibing Guan, Li Xue, Peng Zhang, Mingrui Li, Mei Gao, Tie Chong   +6 more
doaj   +1 more source

Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies [PDF]

, 2019
A significantly increased level of the reactive oxygen species (ROS) scavenger glutathione (GSH) has been identified as a hallmark of renal cell carcinoma (RCC). The proposed mechanism for increased GSH levels is to counteract damaging ROS to sustain the
Meierhofer, David, Xiao, Yi
core   +2 more sources

miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes

Journal of Inflammation Research, 2023
Yongquan Chen, Yecheng Deng, Linghua Chen, Ziyao Huang, Yi Yan, Zhaoqi Huang Department of Cardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaoqi Huang, Department of ...
Chen Y, Deng Y, Chen L, Huang Z, Yan Y, Huang Z   +5 more
doaj  

Intra-Tumoral Expression of SLC7A11 Is Associated with Immune Microenvironment, Drug Resistance, and Prognosis in Cancers: A Pan-Cancer Analysis

Frontiers in Genetics, 2021
While many anti-cancer modalities have shown potent efficacy in clinical practices, cancer prevention, timely detection, and effective treatment are still challenging.
Jiajun He, Hongjian Ding, Huaqing Li, Zhiyu Pan, Qian Chen   +4 more
doaj   +1 more source

miRNA expression profiles and molecular networks in resting and LPS-activated BV-2 microglia-Effect of cannabinoids. [PDF]

, 2019
Mammalian microRNAs (miRNAs) play a critical role in modulating the response of immune cells to stimuli. Cannabinoids are known to exert beneficial actions such as neuroprotection and immunosuppressive activities. However, the underlying mechanisms which
Coppola, Giovanni, Gao, Fuying, Juknat, Ana, Kozela, Ewa, Vogel, Zvi   +4 more
core   +2 more sources

High SLC7A11 expression in normal skin of melanoma patients [PDF]

Cancer Epidemiology, 2019
Melanoma is one of the highest metastatic cancers and its incidence is rapidly increasing. A great effort has been devoted to determine gene mutations and expression profiles in melanoma cells, but less attention has been given to the possible influence of melanin synthesis in melanocytes on melanomagenesis.
Galván, Ismael, Inácio, Ângela, Dañino, María, Corbí-Llopis, Rosa, Monserrat, María T., Bernabeu-Wittel, José   +5 more
openaire   +5 more sources