Results 51 to 60 of about 23,034 (273)

The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 [PDF]

Cancer Research, 2019
Abstract Although cell-cycle arrest, senescence, and apoptosis are established mechanisms of tumor suppression, accumulating evidence reveals that ferroptosis, an iron-dependent, nonapoptotic form of cell death, represents a new regulatory pathway in suppressing tumor development.
Tong, Liu, Le, Jiang, Omid, Tavana, Wei, Gu   +3 more
openaire   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

TP53 drives neuronal ferroptosis by promoting KLHL4-mediated SLC7A11 ubiquitination after spinal cord injury

Neural Regeneration Research
Ferroptosis constitutes a pivotal pathological event following spinal cord injury and presents substantial challenges to the restoration of neurological function.
Yu Kang, Qiangwei Li, Tianlun Zhao, Haojie Zhang, Yuejian Sun, Yilong Zhang, Da An, Zongsheng Yin, Yong Xuan, Peigen Xie   +9 more
doaj   +1 more source

Implication of the glutamate-cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis. [PDF]

, 2017
xCT is the specific chain of the cystine/glutamate antiporter, which is widely reported to support anti-oxidant defenses in vivo. xCT is therefore at the crossroads between two processes that are involved in schizophrenia: oxidative stress and ...
Baumann, P.S., Conus, P., Do, K., Ferrari, C., Fournier, M., Monin, A.   +5 more
core   +3 more sources

The SLC7A11: sperm mitochondrial function and non-canonical glutamate metabolism [PDF]

Reproduction, 2020
Abstract Spermatozoa are redox-regulated cells, and stallion spermatozoa, in particular, present an intense mitochondrial activity in which large amounts of reactive oxygen species (ROS) are produced. To maintain the redox potential under physiological conditions, sophisticated mechanisms ought to be present, particularly in the ...
Ortiz-Rodriguez J. M., Martin-Cano F. E., Gaitskell-Phillips G., Silva A., Tapia J. A., Gil M. C., Redondo E., Masot J., Ortega-Ferrusola C., Pena F. J.   +9 more
openaire   +3 more sources

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Correlations of P53, SLC7A11, CD3+ T cells, and CD8+ T cells with pathological features and prognosis in endometrial carcinoma: Insights from an Asian cohort [PDF]

Journal of Medical Biochemistry
Background: This study investigates the clinical significance of Solute Carrier Family 7 Member 11 (SLC7A11), Tumor Protein p53 (p53), c D3+ T cells, and CD8+ T cells in endometrial carcinoma (EC). By evaluating their expression patterns and correlations
Lv Yuanjie, Zhou Weiwei, Zhang Jingyu, Feng Jing, Xing Rongge, Miao Zhigang   +5 more
doaj   +1 more source

SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells

Nature Communications, 2023
The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT) protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we report a surprising finding that, whereas moderate overexpression of SLC7A11 is
Yuelong Yan, Hongqi Teng, Qinglei Hang, Lavanya Kondiparthi, Guang Lei, Amber Horbath, Xiaoguang Liu, Chao Mao, Shiqi Wu, Li Zhuang, M. James You, Masha V. Poyurovsky, Li Ma, Kellen Olszewski, Boyi Gan   +14 more
doaj   +1 more source

Increased Expression of System x_c^- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance [PDF]

, 2016
Glioblastoma multiforme is the most aggressive malignant primary brain tumor in adults. Several studies have shown that glioma cells upregulate the expression of xCT (SLC7A11), the catalytic subunit of system x_c^-, a transporter involved in cysteine ...
Aboody, Karen S., Cassady, Kaniel, Cherryholmes, Gregory A., Marinov, Georgi K., Polewski, Monika D., Reveron-Thornton, Rosyli F.   +5 more
core  

Differential expression of SLC7A11 in colorectal cancer.

, 2023
Cancer is a leading cause of death and colorectal cancer is among the most lethal cancers (1, 2). We mined published microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with colorectal cancer (CRC). We found significant differential
openaire   +1 more source