Results 51 to 60 of about 20,364 (275)

Identification of SLC7A11‐AS1/SLC7A11 pair as a ferroptosis‐related therapeutic target for hepatocellular carcinoma

Journal of Cellular and Molecular Medicine
AbstractHepatocellular carcinoma (HCC), a prevalent malignancy worldwide, poses significant challenges in terms of prognosis, necessitating innovative therapeutic approaches. Ferroptosis offers notable advantages over apoptosis, holding promise as a novel therapeutic approach for HCC complexities. Moreover, while the interaction between long non‐coding
Xiao Yuan, Yida Wang, Sitong Jiao, Huanhuan Gao, Mengqian Zhang, Xin Wang, Xunyu Zhou, Chuanfang Wu, Jinku Bao   +8 more
openaire   +2 more sources

Image_3_MiR-27a-3p Promotes Non-Small Cell Lung Cancer Through SLC7A11-Mediated-Ferroptosis.tif

, 2021
BackgroundFerroptosis is a newly generated regulatory cell death promoted by the accumulated lipid-based reactive oxygen species (ROS). Solute carrier family 7 member 11 (SLC7A11), the cystine/glutamate antiporter, is known as a ferroptosis executor that
Xinxin Ling (11556379), Shan Gao (46743), Wenjing Du (746902), Ningning Kang (11556376), Xuan Lu (325437), Ming Pan (1278351)   +5 more
core   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Image_2_MiR-27a-3p Promotes Non-Small Cell Lung Cancer Through SLC7A11-Mediated-Ferroptosis.tif

, 2021
BackgroundFerroptosis is a newly generated regulatory cell death promoted by the accumulated lipid-based reactive oxygen species (ROS). Solute carrier family 7 member 11 (SLC7A11), the cystine/glutamate antiporter, is known as a ferroptosis executor that
Xinxin Ling (11556379), Shan Gao (46743), Wenjing Du (746902), Ningning Kang (11556376), Xuan Lu (325437), Ming Pan (1278351)   +5 more
core   +1 more source

Intra-Tumoral Expression of SLC7A11 Is Associated with Immune Microenvironment, Drug Resistance, and Prognosis in Cancers: A Pan-Cancer Analysis

Frontiers in Genetics, 2021
While many anti-cancer modalities have shown potent efficacy in clinical practices, cancer prevention, timely detection, and effective treatment are still challenging.
Jiajun He, Hongjian Ding, Huaqing Li, Zhiyu Pan, Qian Chen   +4 more
doaj   +1 more source

Image_1_MiR-27a-3p Promotes Non-Small Cell Lung Cancer Through SLC7A11-Mediated-Ferroptosis.tif

, 2021
BackgroundFerroptosis is a newly generated regulatory cell death promoted by the accumulated lipid-based reactive oxygen species (ROS). Solute carrier family 7 member 11 (SLC7A11), the cystine/glutamate antiporter, is known as a ferroptosis executor that
Xinxin Ling (11556379), Shan Gao (46743), Wenjing Du (746902), Ningning Kang (11556376), Xuan Lu (325437), Ming Pan (1278351)   +5 more
core   +1 more source

SLC7A11 is an unconventional H+ transporter in lysosomes

Cell
Lysosomes maintain an acidic pH of 4.5-5.0, optimal for macromolecular degradation. Whereas proton influx is produced by a V-type H+ ATPase, proton efflux is mediated by a fast H+ leak through TMEM175 channels, as well as an unidentified slow pathway. A candidate screen on an orphan lysosome membrane protein (OLMP) library enabled us to discover that ...
Nan Zhou, Jingzhi Chen, Meiqin Hu, Na Wen, Weijie Cai, Ping Li, Liding Zhao, Yaping Meng, Dongdong Zhao, Xiaotong Yang, Siyu Liu, Fangqian Huang, Cheng Zhao, Xinghua Feng, Zikai Jiang, Enjun Xie, Hongxu Pan, Zhidong Cen, Xinhui Chen, Wei Luo, Beisha Tang, Junxia Min, Fudi Wang, Junsheng Yang, Haoxing Xu   +24 more
openaire   +2 more sources

The DUBA-SLC7A11-c-Myc Axis is Critical for Stemness and Ferroptosis

SSRN Electronic Journal, 2022
Abstract Ferroptosis is characterized by the accumulation of lipid peroxidation as a unique iron-dependent cell death. However, the interplay between stemness and ferroptosis remains unknown. Here, we demonstrate that undifferentiated cells are more sensitive to ferroptosis than differentiated cells, and cystine transporter SLC7A11 protein is ...
Zuli Wang, Lianlian Ouyang, Na Liu, Tiansheng Li, Bokang Yan, Chao Mao, Desheng Xiao, Boyi Gan, Shuang Liu, Yongguang Tao   +9 more
openaire   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11

, 2020
Ferroptosis is a type of adaptive cell death driven by cellular metabolism and iron‐dependent lipid peroxidation. Though multiple genes (including SLC7A11 and GPX4) have been demonstrated to play key roles in ferroptosis, little is known about the ...
Meiqi Wang, Haihua Wang, Zhenbo Hu, Chengliang Zhang, Xin Xu, Yong Yang, Yao Zhao, Yishu Wang   +7 more
core   +1 more source