Results 61 to 70 of about 20,364 (275)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

TRIM21 accelerates ferroptosis in intervertebral disc degeneration by promoting SLC7A11 ubiquitination and degradation

Open Life Sciences
Intervertebral disc degeneration (IVDD) is a common cause of chronic low back pain, and ferroptosis – an iron-dependent form of cell death – has been linked to oxidative stress-induced damage in nucleus pulposus cells (NPCs).
Yu Wei, Liu Yong, Zhou Feng
doaj   +1 more source

MiR-27a-3p Promotes Non-Small Cell Lung Cancer Through SLC7A11-Mediated-Ferroptosis

Frontiers in Oncology, 2021
BackgroundFerroptosis is a newly generated regulatory cell death promoted by the accumulated lipid-based reactive oxygen species (ROS). Solute carrier family 7 member 11 (SLC7A11), the cystine/glutamate antiporter, is known as a ferroptosis executor that
Xuan Lu, Ningning Kang, Xinxin Ling, Ming Pan, Wenjing Du, Shan Gao   +5 more
doaj   +1 more source

The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 [PDF]

Cancer Research, 2019
Abstract Although cell-cycle arrest, senescence, and apoptosis are established mechanisms of tumor suppression, accumulating evidence reveals that ferroptosis, an iron-dependent, nonapoptotic form of cell death, represents a new regulatory pathway in suppressing tumor development.
Tong, Liu, Le, Jiang, Omid, Tavana, Wei, Gu   +3 more
openaire   +2 more sources

Figure S1 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

, 2021
Validation of SLC7A11 antibodies and SLC7A11 knockdown in CAFs and PDAC cells in vitro.
Jorjina Kasparian (14949258), Jeff Holst (14949216), Estrella Gonzales-Aloy (14949246), Jennifer P. Morton (9143584), Brooke A. Pereira (14949225), Sigrid K. Fey (14942140), Angela Chou (519815), Amber Johns (3988427), Nigel Turner (166154), Anouschka Akerman (14215337), Joshua A. McCarroll (12502138), Andrew D. Campbell (9772366), Yi Fang Guan (14949249), Yordanos F. Setargew (14949264), Anthony J. Gill (14949243), Mert Erkan (54888), Minoti V. Apte (14949252), Cyrille Boyer (1352049), Benjamin J. McLean (14949261), Julia Lee (2002213), Koroush S. Haghighi (14949255), George Sharbeen (14949207), Jessica L. Chitty (14949228), David Goldstein (14949219), Arafath K. Najumudeen (14949231), Paul Timpson (841144), Janet Youkhana (2855546), Stephanie Naim (390408), Phoebe A. Phillips (14949267), Chantal Kopecky (14949210), Thomas R. Cox (14949222), Nelson Russia (14949240), John Kokkinos (14949213), Val Gebski (732415), Owen J. Sansom (14949234), Thomas P. Davis (521458), Rosa Mistica C. Ignacio (3207519), Marina Pajic (132629), Jie Liu (14949237)   +38 more
core   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Correlations of P53, SLC7A11, CD3+ T cells, and CD8+ T cells with pathological features and prognosis in endometrial carcinoma: Insights from an Asian cohort [PDF]

Journal of Medical Biochemistry
Background: This study investigates the clinical significance of Solute Carrier Family 7 Member 11 (SLC7A11), Tumor Protein p53 (p53), c D3+ T cells, and CD8+ T cells in endometrial carcinoma (EC). By evaluating their expression patterns and correlations
Lv Yuanjie, Zhou Weiwei, Zhang Jingyu, Feng Jing, Xing Rongge, Miao Zhigang   +5 more
doaj   +1 more source

The SLC7A11: sperm mitochondrial function and non-canonical glutamate metabolism [PDF]

Reproduction, 2020
Abstract Spermatozoa are redox-regulated cells, and stallion spermatozoa, in particular, present an intense mitochondrial activity in which large amounts of reactive oxygen species (ROS) are produced. To maintain the redox potential under physiological conditions, sophisticated mechanisms ought to be present, particularly in the ...
Ortiz-Rodriguez J. M., Martin-Cano F. E., Gaitskell-Phillips G., Silva A., Tapia J. A., Gil M. C., Redondo E., Masot J., Ortega-Ferrusola C., Pena F. J.   +9 more
openaire   +3 more sources

The ubiquitin hydrolase OTUB1 promotes glioma cell stemness via suppressing ferroptosis through stabilizing SLC7A11 protein

, 2021
The ubiquitin hydrolase OTUB1 has been elucidated to be highly expressed in tumors, however, its roles in glioma progression are still confusing. Here, via analyzing several online datasets, OTUB1 expression was shown to be remarkably increased in glioma
Xinde Zhao (11854695), Ming Zhou (73279), Yong Yang (63842), Minjie Luo (373313)   +3 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source