Results 1 to 10 of about 29,940 (117)
Frontiers in Molecular Biosciences, 2022 Glutathione peroxidase 4 (GPX4) is one of the most important antioxidant enzymes. As the key regulator of ferroptosis, GPX4 has attracted considerable attention in the fields of cancer, cardiovascular, and neuroscience research in the past 10 years.
Can Cui +5 more
exaly +3 more sources
Redox Biology, 2021 The antioxidant function of the phospholipid hydroperoxide glutathione peroxidase (GPx4) is vital for the homeostasis of many cell types, from neoplastic cells to normal erythroid precursors.
Thomas J Raife +2 more
exaly +3 more sources
Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
EBioMedicine, 2022 Summary: Background: Osteoarthritis (OA) is the most common joint disease and is the leading cause of chronic disability among older people. Chondrocyte death and extracellular matrix (ECM) degradation was involved in OA pathogenesis. Ferroptosis was an
Jingwei Zhang +2 more
exaly +3 more sources
The mechanism of irisin via Nrf2/GPX4 signaling pathway in alleviating lipopolysaccha-ride-induced acute lung injury in rats [PDF]
Yixue xinzhi zazhi, 2023 Objective To study the role of Nrf2/GPX4 signaling pathway in irisin alleviating lipopoly-saccharide (LPS)-induced acute lung injury in rats.Method Seventy-two healthy male SD rats were ran-domly divided into control group (C group), acute lung injury ...
Jing LUO +4 more
doaj +1 more source
Effects of nano-selenium and sodium selenite on SelP, GPx4 and SelW genes expression in testes of broiler breeder roosters [PDF]
Bulgarian Journal of Veterinary Medicine, 2020 Fertility is the main element affecting hatchability as an important indicator in breeder flocks’ per-formance. Roosters’ aging reduces their fertility.
H. Jafarzadeh +4 more
doaj +1 more source
Animal Cells and Systems, 2021 Selenium (Se) is a vital element of life, which has an important impact on the growth, development, production performance and stress-tolerance of animals. However, it is not entirely clear that how exactly Se works during these processes.
Lu Liu +4 more
doaj +1 more source
European Journal of Histochemistry, 2022 Cellular senescence and ferroptosis are the two main, fine-tuned processes in tissue damage restraint; however, they can be overactivated in pathologies such as nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH), becoming ...
Antonella Vetuschi +6 more
doaj +1 more source
Wedelolactone attenuates cerebral ischemia-reperfusion injury by blocking GPX4-mediated ferroptosis [PDF]
Journal of Men's Health, 2023 Cerebral ischemia is currently the third leading cause of death worldwide. Among its complications, cerebral ischemia-reperfusion (I/R) is considered the most inevitable problem.
Huyin Yang, Dai Liu, Yanping Wang
doaj +1 more source
Gut Microbes, 2021 Ferroptosis, a new type of cell death has been found to aggravate intestinal ischemia/reperfusion (I/R) injury. However, little is known about the changes of gut microbiota and metabolites in intestinal I/R and the role of gut microbiota metabolites on ...
Fan Deng +10 more
doaj +1 more source
Iron Overload and Excitotoxicity: Connecting Ferroptosis with Epileptic Seizures [PDF]
Archives of Pharmaceutical Sciences Ain Shams UniversityEpilepsy diagnosis requires the occurrence of at least one seizure, while status epilepticus (SE) is a life-threatening condition with prolonged seizures without a return to baseline consciousness, often requiring emergency intervention.
Mina Y. George +2 more
doaj +1 more source