Results 1 to 10 of about 33,780 (159)
Frontiers in Molecular Biosciences, 2022 Glutathione peroxidase 4 (GPX4) is one of the most important antioxidant enzymes. As the key regulator of ferroptosis, GPX4 has attracted considerable attention in the fields of cancer, cardiovascular, and neuroscience research in the past 10 years.
Can Cui +5 more
exaly +3 more sources
Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy [PDF]
Molecular Metabolism, 2015 Objective: Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear.
Lalage A. Katunga +11 more
doaj +4 more sources
Redox Biology, 2021 The antioxidant function of the phospholipid hydroperoxide glutathione peroxidase (GPx4) is vital for the homeostasis of many cell types, from neoplastic cells to normal erythroid precursors.
Jeffrey M Stolwijk +2 more
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Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
EBioMedicine, 2022 Summary: Background: Osteoarthritis (OA) is the most common joint disease and is the leading cause of chronic disability among older people. Chondrocyte death and extracellular matrix (ECM) degradation was involved in OA pathogenesis. Ferroptosis was an
Feng Xue, Junjie Gao, Changqing Zhang
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Frontiers in Oncology, 2020 Gefitinib resistance in triple negative breast cancer (TNBC) is a growing important concern. Glutathione peroxidase 4 (GPX4) is a main regulator of ferroptosis, which is pivotal for TNBC cell growth. We investigated GPX4-mediated ferroptosis in gefitinib
Xiang Song +3 more
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The mechanism of irisin via Nrf2/GPX4 signaling pathway in alleviating lipopolysaccha-ride-induced acute lung injury in rats [PDF]
Yixue xinzhi zazhi, 2023 Objective To study the role of Nrf2/GPX4 signaling pathway in irisin alleviating lipopoly-saccharide (LPS)-induced acute lung injury in rats.Method Seventy-two healthy male SD rats were ran-domly divided into control group (C group), acute lung injury ...
Jing LUO +4 more
doaj +1 more source
Effects of nano-selenium and sodium selenite on SelP, GPx4 and SelW genes expression in testes of broiler breeder roosters [PDF]
Bulgarian Journal of Veterinary Medicine, 2020 Fertility is the main element affecting hatchability as an important indicator in breeder flocks’ per-formance. Roosters’ aging reduces their fertility.
H. Jafarzadeh +4 more
doaj +1 more source
Wedelolactone attenuates cerebral ischemia-reperfusion injury by blocking GPX4-mediated ferroptosis [PDF]
Journal of Men's Health, 2023 Cerebral ischemia is currently the third leading cause of death worldwide. Among its complications, cerebral ischemia-reperfusion (I/R) is considered the most inevitable problem.
Huyin Yang, Dai Liu, Yanping Wang
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European Journal of Histochemistry, 2022 Cellular senescence and ferroptosis are the two main, fine-tuned processes in tissue damage restraint; however, they can be overactivated in pathologies such as nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH), becoming ...
Antonella Vetuschi +6 more
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Animal Cells and Systems, 2021 Selenium (Se) is a vital element of life, which has an important impact on the growth, development, production performance and stress-tolerance of animals. However, it is not entirely clear that how exactly Se works during these processes.
Lu Liu +4 more
doaj +1 more source