Results 41 to 50 of about 33,929 (300)

A 3D cell death assay to quantitatively determine ferroptosis in spheroids [PDF]

, 2020
The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening.
Declercq, Heidi, Demuynck, Robin, Efimova, Iuliia, Krysko, Dmitri, Lin, Abraham   +4 more
core   +1 more source

Characterization of a patient-derived variant of GPX4 for precision therapy

Nature Chemical Biology, 2021
Glutathione peroxidase 4 (GPX4), as the only enzyme in mammals capable of reducing esterified phospholipid hydroperoxides within a cellular context, protects cells from ferroptosis. We identified a homozygous point mutation in the GPX4 gene, resulting in an R152H coding mutation, in three patients with Sedaghatian-type spondylometaphyseal dysplasia ...
Hengrui Liu, Farhad Forouhar, Tobias Seibt, Russell Saneto, Kristen Wigby, Jennifer Friedman, Xin Xia, Mikhail S. Shchepinov, Sanath Kumar Ramesh, Marcus Conrad, Brent R. Stockwell   +10 more
openaire   +3 more sources

Legumain level in patients with gestational diabetes to promote ferroptosis through liver gluconeogenesis by HSP90 and GPX4

Food & Nutrition Research
Background: The incidence of gestational diabetes mellitus (GDM) is the first diabetes in pregnancy and has gradually increased worldwide, increasing the burden of social healthcare systems.
Yingda Yan, Huafang Liu, Xiaodi Kang, Hongli Jiang, Wenjing Wang, Yanli Xu, Fanwen Yang   +6 more
doaj   +1 more source

Traditional Chinese Formula Xiaoyaosan Alleviates Depressive-Like Behavior in CUMS Mice by Regulating PEBP1-GPX4-Mediated Ferroptosis in the Hippocampus

Neuropsychiatric Disease and Treatment, 2021
Haiyan Jiao,1 Hongjun Yang,1 Zhiyi Yan,1 Jianbei Chen,1 Mengbai Xu,1 Youming Jiang,1 Yueyun Liu,1 Zhe Xue,1 Qingyu Ma,2 Xiaojuan Li,2 Jiaxu Chen1,2 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People ...
Jiao H, Yang H, Yan Z, Chen J, Xu M, Jiang Y, Liu Y, Xue Z, Ma Q, Li X, Chen J   +10 more
doaj  

Selenium and vascular health [PDF]

, 2011
Peer reviewedPublisher ...
Sneddon, Alan A.
core   +1 more source

Gene expression profile of oxidative stress in the lung of inbred mice after intestinal ischemia/reperfusion injury [PDF]

, 2014
PURPOSE:To determine the gene expression profile associated with oxidative stress and antioxidant defense in the lung tissue of mice subjected to intestinal ischemia and reperfusion.METHODS:Twelve male, inbred mice (C57BL/6) were randomly assigned to one
Bertoletto, Eduardo Rodrigues, Bertoletto, Paulo Roberto, Chaves, Jose Carlos, Fagundes, Djalma José, Ikejiri, Adauto Tsutomu, Somaio Neto, Frederico, Taha, Murched Omar, Teruya, Roberto   +7 more
core   +3 more sources

Involvement of sperm acetylated histones and the nuclear isoform of Glutathione peroxidase 4 in fertilization [PDF]

, 2017
We previously demonstrated that the nuclear form of Glutathione peroxidase 4 (nGPx4) has a peculiar distribution in sperm head, being localized to nuclear matrix and acrosome and that sperm lacking nGPx4 are more prone to decondensation in vitro. In this
Boitani, Carla, Esposito, Valentina, Fiorenza, Maria T., Fuso, Andrea, Lucarelli, Marco, Mangia, Franco, Mularoni, Valentina, Pipolo, Simona, Puglisi, Rossella   +8 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Regulation of Redox Signaling by Selenoproteins [PDF]

, 2010
The unique chemistry of oxygen has been both a resource and threat for life on Earth for at least the last 2.4 billion years. Reduction of oxygen to water allows extraction of more metabolic energy from organic fuels than is possible through anaerobic ...
Wayne Chris Hawkes, Zeynep Alkan
core   +1 more source