Results 41 to 50 of about 34,214 (293)

GPx4 expression in RPE/choroid.

, 2014
(A) Similar appearance of GPx4+/−, GPx4+/+ and GPx4+/+:Tg (GPx4) mice at 3 months of age expressing different levels of GPx4. (B) Hematoxylin-eosin staining of the retina and RPE/choroid of the mice expressing different levels of GPx4.
Hirotaka Imai (241758), Yasuo Noda (102855), Murilo Felix Roggia (102866), Tomoyasu Shiraya (572557), Takashi Ueta (102880)   +4 more
core   +1 more source

NeuroD1 positively regulates GPX4.

, 2023
(A) Physical interactions between endogenous NeuroD1 and RNA polymerase II protein in HCC-LM3 cells, as determined by anti-RNA polymerase II immunoblotting of cell lysate immunoprecipitated with anti-NeuroD1 antibody.
Wei Duan (101868), Zheng Wu (344022), Lingxian Wang (4634977), Shourong Wu (391683), Rendy Hosea (17697125), Cao Ruan (16627266), Ping Huang (30439), Jianting Zeng (17697128), Vivi Kasim (391682)   +8 more
core   +1 more source

Legumain level in patients with gestational diabetes to promote ferroptosis through liver gluconeogenesis by HSP90 and GPX4

Food & Nutrition Research
Background: The incidence of gestational diabetes mellitus (GDM) is the first diabetes in pregnancy and has gradually increased worldwide, increasing the burden of social healthcare systems.
Yingda Yan, Huafang Liu, Xiaodi Kang, Hongli Jiang, Wenjing Wang, Yanli Xu, Fanwen Yang   +6 more
doaj   +1 more source

Protective role of glutathione peroxidase 4 in laser-induced choroidal neovascularization in mice. [PDF]

PLoS ONE, 2014
PURPOSE: To evaluate the influence of glutathione peroxidase 4 (GPx4) expression in retinal pigment epithelium (RPE)/choroid tissue using a mouse model of laser-induced choroidal neovascularization (CNV).
Murilo Felix Roggia, Hirotaka Imai, Tomoyasu Shiraya, Yasuo Noda, Takashi Ueta   +4 more
doaj   +1 more source

Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

Antioxidants, 2022
Glutathione peroxidase 4 (GPX4)-dependent ferroptosis in pancreatic acinar cells plays a critical role in acute pancreatitis (AP). However, potential upstream regulators of GPX4 are not well defined.
Xiaojie Ma, Xiaowu Dong, Yao Xu, Nan Ma, Mei Wei, Xiaochun Xie, Yingying Lu, Wangsen Cao, Guotao Lu, Weiqin Li   +9 more
doaj   +1 more source

A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4

, 2022
Ferroptosis is a nonapoptotic form of cell death characterized by iron-dependent lipid peroxidation and has been implicated in multiple pathological conditions.
Cheng Zhang (70708), Tian-Xiang Wang (14193210), Yun Gao (381225), Zian Xue (13781856), Jin-Pin Liu (11135970), Jia Zheng (140297), Junchi Hu (1720222), Si-Yu Cen (14193207), Yue Xiong (794009), Kun-Liang Guan (794010), Hai-Xin Yuan (11135976), Shenyou Nie (1832002)   +11 more
core   +1 more source

Characterization of a patient-derived variant of GPX4 for precision therapy

Nature Chemical Biology, 2021
Glutathione peroxidase 4 (GPX4), as the only enzyme in mammals capable of reducing esterified phospholipid hydroperoxides within a cellular context, protects cells from ferroptosis. We identified a homozygous point mutation in the GPX4 gene, resulting in an R152H coding mutation, in three patients with Sedaghatian-type spondylometaphyseal dysplasia ...
Hengrui Liu, Farhad Forouhar, Tobias Seibt, Russell Saneto, Kristen Wigby, Jennifer Friedman, Xin Xia, Mikhail S. Shchepinov, Sanath Kumar Ramesh, Marcus Conrad, Brent R. Stockwell   +10 more
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Traditional Chinese Formula Xiaoyaosan Alleviates Depressive-Like Behavior in CUMS Mice by Regulating PEBP1-GPX4-Mediated Ferroptosis in the Hippocampus

Neuropsychiatric Disease and Treatment, 2021
Haiyan Jiao,1 Hongjun Yang,1 Zhiyi Yan,1 Jianbei Chen,1 Mengbai Xu,1 Youming Jiang,1 Yueyun Liu,1 Zhe Xue,1 Qingyu Ma,2 Xiaojuan Li,2 Jiaxu Chen1,2 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People ...
Jiao H, Yang H, Yan Z, Chen J, Xu M, Jiang Y, Liu Y, Xue Z, Ma Q, Li X, Chen J   +10 more
doaj  

Protective Effects of Vernonia amygdalina Extract Against 1-Nitropyrene-Induced Hepatopulmonary Oxidative Injury in Rats [PDF]

Avicenna Journal of Medical Biochemistry
Background: 1-Nitropyrene (1-NP), an environmental pollutant derived from nitro-polycyclic aromatic hydrocarbons, poses serious environmental hazards.
Omorede Ikponmwosa-Eweka, Ikenna C. Maduako   +1 more
doaj   +1 more source