NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ubiquitination and degradation
Endocrine Connections, 2023 Background: Polycystic ovary syndrome (PCOS) is an androgen disorder and ovarian dysfunction disease in women of reproductive age. The cell death of granulosa cells (GCs) plays an important role in the development of PCOS.
Hong Tang +7 more
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NeuroD1 suppresses ferroptosis by upregulating GPX4.
, 2023 (A) Lipid peroxidation level in NeuroD1-knocked down, GPX4-overexpressed HCC-LM3 cells, as assessed using flow cytometry. Data were presented as % of oxidized/oxidized + reduced MFI (F value = 1762).
Wei Duan (101868) +8 more
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Prognostic value of ferroptosis-related biomarkers ACSL4 and GPX4 in critically ill patients: A systematic review and meta-analysis [PDF]
Journal of Medical BiochemistryBackground: Ferroptosis is a regulated form of cell death. Although ferroptosis has been increasingly implicated in influenza A virus (IAV)-induced lung injury, direct clinical evidence in influenza A patients remains scarce.
Gao Yue, Wang Chengxiang
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Molecular & Cellular Oncology, 2021 Our recent study revealed that non-neuroendocrine small cell lung cancer (SCLC) is sensitive to the induction of ferroptosis due to upregulation of ether lipid synthesis.
Christina M. Bebber, Silvia von Karstedt
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Electrostatic Drivers of GPx4 Interactions with Membrane Lipids, and DNA
, 2021 Glutathione peroxidase 4 (GPx4) serves as the only enzyme that protects membranes through the reduction of lipid hydroperoxides, preventing membrane oxidative damage and cell death through ferroptosis. Recently, GPx4 has gained attention as a therapeutic
Brian Fuglestad +3 more
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The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis
Molecular & Cellular Oncology, 2021 Our recent study showed that two oxidoreductases – NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) – transfer electrons to oxygen to generate hydrogen peroxide (H2O2).
Youwei Ai, Bo Yan, Xiaodong Wang
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Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease. [PDF]
, 2020 The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style.
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HOIP modulates the stability of GPx4 by linear ubiquitination
Proceedings of the National Academy of Sciences, 2022 LUBAC-mediated linear ubiquitination plays a pivotal role in regulation of cell death and inflammatory pathways. Genetic deficiency in LUBAC components leads to severe immune dysfunction or embryonic lethality. LUBAC has been extensively studied for its role in mediating TNF signaling. However, Tnfr1
Kangyun Dong +8 more
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Association between GPX4 and HMGCR gene expression and cell proliferation in atypical hyperplasia of the breast [PDF]
Exploration of MedicineAim: Using a dataset available from the NCBI Gene Expression Omnibus Repository, this in silico study investigated the differential expression of GPX4, the gene coding for the detoxifying enzyme glutathione peroxidase paired samples of AH (atypical ...
Danila Coradini
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Sufentanil attenuates LPS-induced acute lung injury by suppressing ferroptosis and maintaining GPX4 protein abundance. [PDF]
Front Cell Dev BiolIntroduction Acute lung injury (ALI) is a severe inflammatory syndrome characterized by disruption of the alveolar-capillary barrier, pulmonary edema, and impaired gas exchange.
Guo X, Yan W, Peng W, Yan R.
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