Results 31 to 40 of about 33,929 (300)

Association between GPX4 and HMGCR gene expression and cell proliferation in atypical hyperplasia of the breast [PDF]

Exploration of Medicine
Aim: Using a dataset available from the NCBI Gene Expression Omnibus Repository, this in silico study investigated the differential expression of GPX4, the gene coding for the detoxifying enzyme glutathione peroxidase paired samples of AH (atypical ...
Danila Coradini
doaj   +1 more source

Tissue-Specific Orchestration of Gilthead Sea Bream Resilience to Hypoxia and High Stocking Density [PDF]

, 2019
Two different O-2 levels (normoxia: 75-85% O-2 saturation; moderate hypoxia: 42-43% O-2 saturation) and stocking densities (LD: 9.5, and HD: 19 kg/m(3)) were assessed on gilthead sea bream (Sparus aurata) in a 3-week feeding trial.
Ackerman, Alfaro, Almeida, Araújo-Luna, Arends, Ashley, Auer, Balasch, Benedito-Palos, Benedito-Palos, Benedito-Palos, Bergan-Roller, Bermejo-Nogales, Bermejo-Nogales, Bermejo-Nogales, Brett, Brown-Borg, Brown-Borg, Cadiz, Cadiz, Calduch-Giner, Calduch-Giner, Calduch-Giner, Dam, Deutsch, Du, Ekau, Estensoro, Everett, Føre, Gallaugher, Garcia de la Serrana, Gil-Solsona, Gómez-Requeni, Hermes-Lima, Hopkins, Huang, Hulbert, Hulbert, Jensen, Jørgensen, Kajimura, Ke, Kieffer, Lai, Larsen, Li, Livak, Lushchak, Magnoni, Martin, Martos-Sitcha, Martos-Sitcha, Martos-Sitcha, Martínez-Barberá, Martínez-Porchas, McKenzie, Millán-Cubillo, Minchenko, Mommsen, Monternier, Montero, Mosconi, Murray, Nikinmaa, Nikinmaa, Nilsson, Pauletto, Pearson, Person-Le Ruyet, Piazzon, Piazzon, Pichavant, Pickering, Poulain, Pérez-Sánchez, Pérez-Sánchez, Pérez-Sánchez, Pérez-Sánchez, Pérez-Sánchez, Reindl, Remen, Remen, Richards, Rimoldi, Rodrigues, Rolfe, Ruer, Salin, Sangiao-Alvarellos, Saravanan, Shimizu, Simó-Mirabet, Simó-Mirabet, Simó-Mirabet, Skrzynska, Soivio, Speckner, Treins, Val, Valli, Van Weerd, Vega-Rubín de Celis, Vijayan, Vikeså, Vélez, Wells, Wendelaar Bonga, Wold, Wood, Yu, Yáñez, Yúfera, Zhu   +113 more
core   +3 more sources

HOIP modulates the stability of GPx4 by linear ubiquitination

Proceedings of the National Academy of Sciences, 2022
LUBAC-mediated linear ubiquitination plays a pivotal role in regulation of cell death and inflammatory pathways. Genetic deficiency in LUBAC components leads to severe immune dysfunction or embryonic lethality. LUBAC has been extensively studied for its role in mediating TNF signaling. However, Tnfr1 knockout is not
Kangyun Dong, Ran Wei, Taijie Jin, Mengmeng Zhang, Jiali Shen, Huaijiang Xiang, Bing Shan, Junying Yuan, Ying Li   +8 more
openaire   +2 more sources

Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

Antioxidants, 2022
Glutathione peroxidase 4 (GPX4)-dependent ferroptosis in pancreatic acinar cells plays a critical role in acute pancreatitis (AP). However, potential upstream regulators of GPX4 are not well defined.
Xiaojie Ma, Xiaowu Dong, Yao Xu, Nan Ma, Mei Wei, Xiaochun Xie, Yingying Lu, Wangsen Cao, Guotao Lu, Weiqin Li   +9 more
doaj   +1 more source

Selenoprotein gene nomenclature [PDF]

, 2016
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis.
Arn\ue9r, Elias S., Berry, Marla J., Bruford, Elspeth A., Burk, Raymond F., Carlson, Bradley A., Castellano, Sergi, Chavatte, Laurent, Conrad, Marcus, Copeland, Paul R., Diamond, Alan M., Driscoll, Donna M., Ferreiro, Ana, Floh\ue9, Leopold, Gladyshev, Vadim N, Green, Fiona R., Guig\uf3, Roderic, Handy, Diane E., Hatfield, Dolph L., Hesketh, John, Hoffmann, Peter R., Holmgren, Arne, Hondal, Robert J., Howard, Michael T., Huang, Kaixun, K\uf6hrle, Josef, Kim, Hwa Young, Kim, Ick Young, Krol, Alain, Kryukov, Gregory V., Lee, Byeong Jae, Lee, Byung Cheon, Lei, Xin Gen, Lescure, Alain, Liu, Qiong, Lobanov, Alexei V., Loscalzo, Joseph, Maiorino, Matilde, Mariotti, Marco, Prabhu, K. Sandeep, Rayman, Margaret P., Regina, Brigelius Floh\ue9, Rozovsky, Sharon, Salinas, Gustavo, Schmidt, Edward E., Schomburg, Lutz, Schweizer, Ulrich, Simonovi\u107, Miljan, Sunde, Roger A., Tsuji, Petra A., Tweedie, Susan, Ursini, Fulvio, Whanger, Philip D., Zhang, Yan   +52 more
core   +3 more sources

Protective role of glutathione peroxidase 4 in laser-induced choroidal neovascularization in mice. [PDF]

PLoS ONE, 2014
PURPOSE: To evaluate the influence of glutathione peroxidase 4 (GPx4) expression in retinal pigment epithelium (RPE)/choroid tissue using a mouse model of laser-induced choroidal neovascularization (CNV).
Murilo Felix Roggia, Hirotaka Imai, Tomoyasu Shiraya, Yasuo Noda, Takashi Ueta   +4 more
doaj   +1 more source

Monitoring and Regulating Intracellular GPX4 mRNA Using Gold Nanoflare Probes and Enhancing Erastin-Induced Ferroptosis

Biosensors, 2022
Glutathione peroxidase 4 (GPX4) plays an important effect on ferroptosis. Down-regulating the expression of GPX4 mRNA can decrease the content of GPX4. In this work, a gold nanoflare (AuNF) probe loaded with anti-sense sequences targeting for GPX4 mRNA ...
Xiaoyan Liu, Qiangqiang Yang, Yanan Sui, Qiaoli Yue, Shuqing Yan, Chuan Li, Min Hong   +6 more
doaj   +1 more source

Ferroptosis resistance mediated by exosomal release of iron

Molecular & Cellular Oncology, 2020
Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases.
Caitlin W. Brown, Arthur M. Mercurio
doaj   +1 more source

The E3 ligase TRIM26 suppresses ferroptosis through catalyzing K63-linked ubiquitination of GPX4 in glioma

Cell Death and Disease, 2023
The selenium-containing enzyme GPX4 moonlights as a central regulator of ferroptosis, an iron-dependent, nonapoptotic form of regulated cell death caused by lipid peroxidation.
Zhangjie Wang, Yuan Xia, Yang Wang, Ruiqiu Zhu, Hongbo Li, Yu Liu, Na Shen   +6 more
doaj   +1 more source

Concentration of glutathione and expression of glutathione peroxidases 1 and 4 in fresh sperm provide a forecast of the outcome of cryopreservation of human spermatozoa [PDF]

, 2004
Oxidative stress imbalance potentially leads to damage of the structure of the cell and macromolecules such as plasma membrane components, proteins, and DNA.
Garrido, N., Meseguer Anastasio, Manuel Francisco, Pellicer Martínez, Antonio, Remohí Giménez, José, Simón Vallés, Carlos   +4 more
core   +1 more source