Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases [PDF]
FEBS Letters, 1997 Thymine hydroperoxide (5‐hydroperoxymethyluracil), a model compound representing products of oxidative damage to DNA, is a substrate for glutathione peroxidase and some isoforms of glutathione transferase. In this paper, we show that selenium‐dependent human phospholipid hydroperoxide glutathione peroxidase (Se‐PHGPx) exhibits about four orders of ...
Gary Williamson +2 more
exaly +5 more sources
Selective control of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNA stability by selenium supply [PDF]
FEBS Letters, 1996 Selenium depletion of H4 hepatoma cells reduced cytosolic glutathione peroxidase (cGSH‐Px) mRNA abundance but had no effect on phospholipid hydroperoxide glutathione peroxidase (PHGSH‐Px) mRNA abundance. Actinomycin D chase experiments showed that selenium depletion had no effect on the stability of PHGSH‐Px mRNA but decreased the stability of cGSH‐Px ...
Giovanna Bermano +2 more
exaly +5 more sources
Immunocytochemical localisation of phospholipid hydroperoxide glutathione peroxidase in bull’s spermatogenic cells [PDF]
Italian Journal of Animal Science, 2014 Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a selenoprotein, which protects biomembranes from oxidative damages, and it also accounts for almost the entire selenium content of mammalian testis.
Francesco Parillo +4 more
doaj +6 more sources
Docosahexaenoic (DHA) modulates phospholipid-hydroperoxide glutathione peroxidase (Gpx4) gene expression to ensure self-protection from oxidative damage in hippocampal cells [PDF]
Frontiers in Physiology, 2015 Docosahexaenoic acid (DHA, 22:6n-3) is a unique polyunsaturated fatty acid particularly abundant in nerve cell membrane phospholipids. DHA is a pleiotropic molecule that, not only modulates the physicochemical properties and architecture of neuronal ...
Mario Diaz, Noémi Fabelo
exaly +4 more sources
Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness [PDF]
Redox Biology, 2023 Our previous studies support a key role for mitochondrial lipid hydroperoxides as important contributors to denervation-related muscle atrophy, including muscle atrophy associated with aging.
Agnieszka Czyżowska +7 more
doaj +3 more sources
Food Chemistry: X, 2023 The study aimed to assess differences in proteomic and metabolite profiles in ageing (1, 2, 4, and 6 days at 4 °C) beef exudates and determine their relationship with beef muscle iron metabolism and oxidation.
Jun Liu +9 more
doaj +1 more source
Eukaryotic Initiation Factor 4A-3: A Review of Its Physiological Role and Involvement in Oncogenesis
Frontiers in Oncology, 2021 EIF4A3, a member of the DEAD-box protein family, is a nuclear matrix protein and a core component of the exon junction complex (EJC). Under physiological conditions, EIF4A3 participates in post-transcriptional gene regulation by promoting EJC control of ...
Jiazhou Ye +7 more
doaj +1 more source
Reactivity of mitochondrial peroxiredoxins with biological hydroperoxides
Redox Biochemistry and Chemistry, 2023 Mitochondria are main sources of biological hydroperoxides, including hydrogen peroxide, peroxynitrite and various organic hydroperoxides. Most of these species are involved in the regulation of cellular functions when formed at low, physiological levels.
Madia Trujillo +2 more
doaj +1 more source
Metabolism of hydroperoxy-phospholipids in human hepatoma HepG2 cells
Journal of Lipid Research, 1996 Two enzymatic mechanisms have been proposed for the metabolism of hydroperoxy-phospholipids: i) the combined action of phospholipase A2 and glutathione peroxidase, and/or ii) direct enzymatic reduction.
Y Bao, G Williamson
doaj +1 more source
Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases [PDF]
Biochemical Journal, 1998 Human glutathione transferases (GSTs) from Alpha (A), Mu (M) and Theta (T) classes exhibited glutathione peroxidase activity towards phospholipid hydroperoxide. The specific activities are in the order: GST A1-1 > GST T1-1 > GST M1-1 > GST A2-2 > GST A4-4.
R, Hurst +4 more
openaire +2 more sources