Results 21 to 30 of about 26,946 (260)

The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis

Molecular & Cellular Oncology, 2021
Our recent study showed that two oxidoreductases – NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) – transfer electrons to oxygen to generate hydrogen peroxide (H2O2).
Youwei Ai, Bo Yan, Xiaodong Wang
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Regulation of Ferroptotic Cancer Cell Death by GPX4 [PDF]

Cell, 2014
Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules. We used targeted metabolomic profiling to discover that depletion of glutathione causes inactivation of glutathione peroxidases (GPXs) in response to one class of compounds ...
Yang, Wan Seok, SriRamaratnam, Rohitha, Welsch, Matthew E., Shimada, Kenichi, Skouta, Rachid, Viswanathan, Vasanthi S., Cheah, Jaime H., Clemons, Paul A., Shamji, Alykhan F., Clish, Clary B., Brown, Lewis M., Girotti, Albert W., Cornish, Virginia W., Schreiber, Stuart L., Stockwell, Brent R.   +14 more
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Association between GPX4 and HMGCR gene expression and cell proliferation in atypical hyperplasia of the breast [PDF]

Exploration of Medicine
Aim: Using a dataset available from the NCBI Gene Expression Omnibus Repository, this in silico study investigated the differential expression of GPX4, the gene coding for the detoxifying enzyme glutathione peroxidase paired samples of AH (atypical ...
Danila Coradini
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Post-Translational Modification of GPX4 is a Promising Target for Treating Ferroptosis-Related Diseases

Frontiers in Molecular Biosciences, 2022
Glutathione peroxidase 4 (GPX4) is one of the most important antioxidant enzymes. As the key regulator of ferroptosis, GPX4 has attracted considerable attention in the fields of cancer, cardiovascular, and neuroscience research in the past 10 years.
Can Cui, Fei Yang, Fei Yang, Qian Li, Qian Li, Qian Li   +5 more
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HOIP modulates the stability of GPx4 by linear ubiquitination

Proceedings of the National Academy of Sciences, 2022
LUBAC-mediated linear ubiquitination plays a pivotal role in regulation of cell death and inflammatory pathways. Genetic deficiency in LUBAC components leads to severe immune dysfunction or embryonic lethality. LUBAC has been extensively studied for its role in mediating TNF signaling. However, Tnfr1
Kangyun Dong, Ran Wei, Taijie Jin, Mengmeng Zhang, Jiali Shen, Huaijiang Xiang, Bing Shan, Junying Yuan, Ying Li   +8 more
openaire   +2 more sources

Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

Antioxidants, 2022
Glutathione peroxidase 4 (GPX4)-dependent ferroptosis in pancreatic acinar cells plays a critical role in acute pancreatitis (AP). However, potential upstream regulators of GPX4 are not well defined.
Xiaojie Ma, Xiaowu Dong, Yao Xu, Nan Ma, Mei Wei, Xiaochun Xie, Yingying Lu, Wangsen Cao, Guotao Lu, Weiqin Li   +9 more
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Legumain level in patients with gestational diabetes to promote ferroptosis through liver gluconeogenesis by HSP90 and GPX4

Food & Nutrition Research
Background: The incidence of gestational diabetes mellitus (GDM) is the first diabetes in pregnancy and has gradually increased worldwide, increasing the burden of social healthcare systems.
Yingda Yan, Huafang Liu, Xiaodi Kang, Hongli Jiang, Wenjing Wang, Yanli Xu, Fanwen Yang   +6 more
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Traditional Chinese Formula Xiaoyaosan Alleviates Depressive-Like Behavior in CUMS Mice by Regulating PEBP1-GPX4-Mediated Ferroptosis in the Hippocampus

Neuropsychiatric Disease and Treatment, 2021
Haiyan Jiao,1 Hongjun Yang,1 Zhiyi Yan,1 Jianbei Chen,1 Mengbai Xu,1 Youming Jiang,1 Yueyun Liu,1 Zhe Xue,1 Qingyu Ma,2 Xiaojuan Li,2 Jiaxu Chen1,2 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People ...
Jiao H, Yang H, Yan Z, Chen J, Xu M, Jiang Y, Liu Y, Xue Z, Ma Q, Li X, Chen J   +10 more
doaj  

Protective Effects of Vernonia amygdalina Extract Against 1-Nitropyrene-Induced Hepatopulmonary Oxidative Injury in Rats [PDF]

Avicenna Journal of Medical Biochemistry
Background: 1-Nitropyrene (1-NP), an environmental pollutant derived from nitro-polycyclic aromatic hydrocarbons, poses serious environmental hazards.
Omorede Ikponmwosa-Eweka, Ikenna C. Maduako   +1 more
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Ferroptosis resistance mediated by exosomal release of iron

Molecular & Cellular Oncology, 2020
Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases.
Caitlin W. Brown, Arthur M. Mercurio
doaj   +1 more source