Effect of plant-based feed ingredients on osmoregulation in the Atlantic salmon lens [PDF]
, 2010 Lenses of adult Atlantic salmon fed with a plant oil and plant protein-based diet (plant diet) were compared to lenses of fish fed a diet based on traditional marine ingredients (marine diet) with respect to biochemical composition and functionality ex ...
Baslow +52 more
core +1 more source
Selenium and GPX4, a vital symbiosis
Free Radical Biology and Medicine, 2018 Selenium has transitioned from an environmental poison and carcinogen to an essential micronutrient associated with a broad array of health promoting effects. These beneficial effects are now accepted to be linked to its incorporation into selenoproteins, a family of rare proteins utilizing a specialized translation machinery to integrate selenium in ...
Friedmann Angeli, J.P.F., Conrad, M.
openaire +4 more sources
NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ubiquitination and degradation
Endocrine Connections, 2023 Background: Polycystic ovary syndrome (PCOS) is an androgen disorder and ovarian dysfunction disease in women of reproductive age. The cell death of granulosa cells (GCs) plays an important role in the development of PCOS.
Hong Tang +7 more
doaj +1 more source
Rat liver antioxidant response to iron and copper overloads [PDF]
, 2014 The rat liver antioxidant response to Fe and Cu overloads (0–60 mg/kg) was studied. Dose- and time-responses were determined and summarized by t1/2 and C50, the time and the liver metal content for half maximal oxidative responses.
Boveris, Alberto Antonio +8 more
core +1 more source
Molecular & Cellular Oncology, 2021 Our recent study revealed that non-neuroendocrine small cell lung cancer (SCLC) is sensitive to the induction of ferroptosis due to upregulation of ether lipid synthesis.
Christina M. Bebber, Silvia von Karstedt
doaj +1 more source
Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility. [PDF]
, 2015 The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell ...
Aichler, M +12 more
core +1 more source
The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis
Molecular & Cellular Oncology, 2021 Our recent study showed that two oxidoreductases – NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) – transfer electrons to oxygen to generate hydrogen peroxide (H2O2).
Youwei Ai, Bo Yan, Xiaodong Wang
doaj +1 more source
Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]
, 2015 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi +38 more
core +1 more source
Regulation of Ferroptotic Cancer Cell Death by GPX4 [PDF]
Cell, 2014 Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules. We used targeted metabolomic profiling to discover that depletion of glutathione causes inactivation of glutathione peroxidases (GPXs) in response to one class of compounds ...
Yang, Wan Seok +14 more
openaire +2 more sources
MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. [PDF]
, 2018 We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal.
Abe, Hiroshi +10 more
core +3 more sources