Results 11 to 20 of about 34,214 (293)

Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis

Nature Communications
S-palmitoylation is a reversible and widespread post-translational modification, but its role in the regulation of ferroptosis has been poorly understood. Here, we elucidate that GPX4, an essential regulator of ferroptosis, is reversibly palmitoylated on
Yi Zhou, Bin Huang, Hui Wang, Chengqian Yin, Ying Huang, Bo Chu, Meng Hao, Lei Zhang, Shuo Liu, Dan Luo, Yong Nian   +10 more
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Regulation of Ferroptotic Cancer Cell Death by GPX4 [PDF]

Cell, 2014
SummaryFerroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules.
Welsch, Matthew E., Clish, Clary B., Girotti, Albert W., Shamji, Alykhan F., Viswanathan, Vasanthi S., Yang, Wan Seok, Shimada, Kenichi, Brown, Lewis M., Stockwell, Brent R., Cornish, Virginia W., SriRamaratnam, Rohitha, Skouta, Rachid, Schreiber, Stuart L., Cheah, Jaime H., Clemons, Paul A.   +14 more
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Monitoring and Regulating Intracellular GPX4 mRNA Using Gold Nanoflare Probes and Enhancing Erastin-Induced Ferroptosis

Biosensors, 2022
Glutathione peroxidase 4 (GPX4) plays an important effect on ferroptosis. Down-regulating the expression of GPX4 mRNA can decrease the content of GPX4. In this work, a gold nanoflare (AuNF) probe loaded with anti-sense sequences targeting for GPX4 mRNA ...
Xiaoyan Liu, Qiangqiang Yang, Yanan Sui, Qiaoli Yue, Shuqing Yan, Chuan Li, Min Hong   +6 more
doaj   +2 more sources

The High Expression of SLC7A11 and GPX4 are Significantly Correlated with β-Catenin in Colorectal Cancer [PDF]

Cancer Management and Research
Yurong Ou, Ningqi Wu, Lishan Shu, Yang Zhao, Yunfang Bao, Qiong Wu Department of Pathology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, People’s Republic of ChinaCorrespondence: Qiong Wu, Department of Pathology, The First ...
Ou Y, Wu N, Shu L, Zhao Y, Bao Y, Wu Q
doaj   +1 more source

Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation

Pain and Therapy
Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes a significant global public health issue. Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized
Daan Fu, Tianhao Zhang, Daling Deng, Jiwei Shen, Bowen Zhao, Shiwen Fan, Kaixin Wang, Xiangdong Chen   +7 more
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GPX4 activator enhances neuroprotection and functional recovery in spinal cord injury

Journal of Orthopaedic Translation
Background: Spinal cord injury (SCI) exerts severe physical, social, and economic effects on individuals and the healthcare system. While much progress has been made in understanding the pathophysiology of SCI, the regulation of the ferroptosis master ...
Xinjie Liu, Yilin Pang, Baoyou Fan, Jiawei Zhang, Shen Liu, Xiaobing Deng, Yun Li, Ying Liu, Xu Zhang, Chenxi Zhao, Xiaoyu Wang, Xudong Wu, Luhua Lai, Shiqing Feng, Wenpeng Liu, Guangzhi Ning, Xue Yao   +16 more
doaj   +2 more sources

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently [PDF]

, 2019
GPX4 represents a promising yet difficult-to-drug therapeutic target for the treatment of, among others, drug-resistant cancers. While most GPX4 inhibitors rely on a chloroacetamide moiety to modify covalently the protein’s catalytic selenocysteine ...
Richard A., Ruberto, John, Eaton, John Eaton (6248192), Stuart Schreiber (5921467), Anneke, Kramm, Anneke Kramm (6253868), Vasanthi S. Viswanathan (6253891), Stuart, Schreiber, Vasanthi S., Viswanathan, Richard A. Ruberto (6253842)   +9 more
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PDTAC: Targeted photodegradation of GPX4 triggers Ferroptosis and potent antitumor immunity [PDF]

, 2022
Targeted degradation of proteins, especially those regarded as ‘undruggable’, attracts wide attention to develop novel potential therapeutic strategy. GPX4, a key enzyme regulating ferroptosis, is such a target whose inhibition is currently limited to ...
Sufang, Shui, Yingxian, Cui, Tairan, Yuwen, Suwei, Dong, Sijin, Liu, Xi, Zhao, Biao, Wang, Guoquan, Liu   +7 more
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GPX4 in cell death, autophagy, and disease

Autophagy, 2023
Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX (phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use of glutathione as a reducing agent in scavenging lipid peroxidation products. There are three GPX4 isoforms: cytosolic (cGPX4), mitochondrial (mGPX4), and nuclear (nGPX4), with distinct ...
Yangchun Xie, Rui Kang, Daniel J. Klionsky, Daolin Tang   +3 more
openaire   +2 more sources

The role of GPX4 in intestinal homeostasis

, 2021
Die Inzidenz und Prävalenz von Morbus Crohn nimmt weltweit zu. Epidemiologische Studien konnten einen Zusammenhang von Krankheitsentstehung, - verlauf und der Aufnahme von Nahrungsmitteln zeigen.
Grabherr, Felix Sebastian
core   +4 more sources