Results 11 to 20 of about 26,946 (260)
Wedelolactone attenuates cerebral ischemia-reperfusion injury by blocking GPX4-mediated ferroptosis [PDF]
Journal of Men's Health, 2023 Cerebral ischemia is currently the third leading cause of death worldwide. Among its complications, cerebral ischemia-reperfusion (I/R) is considered the most inevitable problem.
Huyin Yang, Dai Liu, Yanping Wang
doaj +1 more source
Gut Microbes, 2021 Ferroptosis, a new type of cell death has been found to aggravate intestinal ischemia/reperfusion (I/R) injury. However, little is known about the changes of gut microbiota and metabolites in intestinal I/R and the role of gut microbiota metabolites on ...
Fan Deng +10 more
doaj +1 more source
The Modulatory Effect of Liraglutide on the Expression of GPX4, HO-1 and SLC7A11 Signaling Pathway in Obese Rats [PDF]
Pharmaceutical SciencesBackground: Obesity, a multifaceted metabolic condition, is associated with oxidative stress and disrupted redox homeostasis, leading to ferroptosis and metabolic dysfunction. Liraglutide, a well-known glucagon-like peptide-1 (GLP-1) receptor agonist, is
Mahmood Jameel Saeed, Inam Sameh Arif
doaj +1 more source
Iron Overload and Excitotoxicity: Connecting Ferroptosis with Epileptic Seizures [PDF]
Archives of Pharmaceutical Sciences Ain Shams UniversityEpilepsy diagnosis requires the occurrence of at least one seizure, while status epilepticus (SE) is a life-threatening condition with prolonged seizures without a return to baseline consciousness, often requiring emergency intervention.
Mina Y. George +2 more
doaj +1 more source
A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis
Molecular & Cellular Oncology, 2021 Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
doaj +1 more source
Hypermethylation of the Nrf2 Promoter Induces Ferroptosis by Inhibiting the Nrf2-GPX4 Axis in COPD
International Journal of COPD, 2021 Zixiao Zhang,1,* Congli Fu,1,2,* Jiaxin Liu,1 Xiaoyan Sai,1 Chu Qin,1 Tingting Di,1 Yue Yang,1 Yan Wu,1 Tao Bian1 1Department of Respiratory Medicine, Wuxi People’s Hospital Affiliated to Nanjing, Medical University, Wuxi, Jiangsu, 214023, People’
Zhang Z +8 more
doaj
Selenium and GPX4, a vital symbiosis
Free Radical Biology and Medicine, 2018 Selenium has transitioned from an environmental poison and carcinogen to an essential micronutrient associated with a broad array of health promoting effects. These beneficial effects are now accepted to be linked to its incorporation into selenoproteins, a family of rare proteins utilizing a specialized translation machinery to integrate selenium in ...
Friedmann Angeli, J.P.F., Conrad, M.
openaire +4 more sources
Nature Chemical Biology, 2020 Ferroptosis induced by GPX4 inhibition offers promise for killing drug-resistant cancer cells, yet current GPX4 inhibitors lack selectivity. The discovery of masked nitrile oxide electrophiles as selective prodrug inhibitors of GPX4 points to an attractive path for chemically inducing ferroptosis.
Stefan G. Kathman, Benjamin F. Cravatt
openaire +2 more sources
NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ubiquitination and degradation
Endocrine Connections, 2023 Background: Polycystic ovary syndrome (PCOS) is an androgen disorder and ovarian dysfunction disease in women of reproductive age. The cell death of granulosa cells (GCs) plays an important role in the development of PCOS.
Hong Tang +7 more
doaj +1 more source
Molecular & Cellular Oncology, 2021 Our recent study revealed that non-neuroendocrine small cell lung cancer (SCLC) is sensitive to the induction of ferroptosis due to upregulation of ether lipid synthesis.
Christina M. Bebber, Silvia von Karstedt
doaj +1 more source