Results 1 to 10 of about 1,487 (157)

Molecular landmarks of tumor disulfidptosis across cancer types to promote disulfidptosis-target therapy

Redox Biology, 2023
The mystery about the mechanistic basis of disulfidptosis has recently been unraveled and shows promise as an effective treatment modality for triggering cancer cell death.
Furong Zeng, Guangtong Deng, Yating Dian   +2 more
exaly   +5 more sources

Identification of disulfidptosis-related subtypes in gastric cancer and GAMT is a key gene during disulfidptosis

Scientific Reports
Recent studies have found that disulfidptosis occurs in cells under glucose starvation. The role of this programmed death method in gastric cancer remains to be explored.
Wenxue Wu, Zhiqing Chen
exaly   +4 more sources

Multi‐omics analysis of disulfidptosis regulators and therapeutic potential reveals glycogen synthase 1 as a disulfidptosis triggering target for triple‐negative breast cancer

MedComm
Disruption of disulfide homeostasis during biological processes can have fatal consequences. Excess disulfides induce cell death in a novel manner, termed as “disulfidptosis.” However, the specific mechanism of disulfidptosis has not yet been elucidated.
Hailin Tang, Yutian Zou
exaly   +2 more sources

Integrated spatial and single‑cell transcriptomics maps disulfidptosis in renal cell carcinoma and reveals PDLIM1 as a prognostic biomarker and potential therapeutic target [PDF]

Translational Oncology
Background: Disulfidptosis is a regulated cell death program linked to redox stress, metabolism, and the actin cytoskeleton. Its organization in tissue and clinical relevance in renal cell carcinoma are not well defined.
Wenqiang Liu, Xianglin Liu, Juan Yi, Zhao Tang, Ziwen Dai, Jiaao Song, Tong Chen, Jun Wang, Jiaxuan Wang, Wentao Jiang, Aimin Jiang, Zhenjie Wu, Lifang Tang, Yuming Jin, Yinghu Chen, Linhui Wang   +15 more
doaj   +2 more sources

Crosstalk among disulfidptosis-related lncRNAs in lung adenocarcinoma reveals a correlation with immune profile and clinical prognosis

Non-coding RNA Research
Disulfidptosis refers to a specific programmed cell death process characterized by the accumulation of disulfides. It has recently been reported in several cancers. However, the impact of disulfidptosis-related long non-coding RNAs (lncRNAs) on malignant
Dong-Liang Lin, Yuanyong Wang, Xiao-Kun Hu   +2 more
exaly   +3 more sources

Role of Disulfidptosis in the Local Inflammatory Response of Atopic Dermatitis [PDF]

Clinical and Translational Allergy
Background Understanding cell death pathways is critical for elucidating the mechanisms underlying inflammation in atopic dermatitis (AD). This study investigates the role of disulfidptosis, a novel form of programmed cell death, in AD pathogenesis ...
Dong‐Mei Zhou, Cheng Chen, Yuan‐Fen Liao, Xi‐Meng Ma, Xin‐Hui Gong, Cheng‐Jun Cui, Yu‐Bao Cui   +6 more
doaj   +2 more sources

BHLHE41–SLC7A11 transcriptional axis and chromatin remodeling signatures in osteogenic-lineage disulfidptosis-like stress in osteoporosis [PDF]

Frontiers in Genetics
BackgroundOsteoporosis (OP) is characterized by impaired bone homeostasis in which bone resorption exceeds bone formation. Disulfidptosis, a recently described disulfide stress–induced cell death program linked to cytoskeletal collapse, has been ...
Xiaoming Zhao, Wenya Xue, Jun Gao, Yilei Zhang, Jinghong Chen, Yingang Zhang, Song Long   +6 more
doaj   +2 more sources

The role of disulfidptosis-driven tumor microenvironment remodeling in pancreatic cancer progression [PDF]

Frontiers in Immunology
BackgroundPancreatic ductal adenocarcinoma (PDAC) continues to pose a significant clinical challenge due to its high mortality rate and limited treatment efficacy.
Wenhao Li, Jiewen Deng, Hao Zhang, Menghan Zhang, Chuanxu Kang, Zicheng Yu, Yunshen Gu, Xiaobo He, Yanfeng Wu   +8 more
doaj   +2 more sources

DCS, a novel classifier system based on disulfidptosis reveals tumor microenvironment heterogeneity and guides frontline therapy for clear cell renal carcinoma

Journal of the National Cancer Center
Background: Emerging evidence suggests that cell deaths are involved in tumorigenesis and progression, which may be treated as a novel direction of cancers. Recently, a novel type of programmed cell death, disulfidptosis, was discovered.
Linhui Wang
exaly   +3 more sources

Disulfidptosis: a new target for central nervous system disease therapy

Frontiers in Neuroscience
Disulfidptosis is a pathologic process that occurs under conditions of NADPH deficiency and excess disulfide bonds in cells that express high levels of SLC7A11.
Zhigang Mei, Jun Liao, Liao Jun
exaly   +3 more sources