Results 41 to 50 of about 2,022 (185)

Disulfidptosis: a new form of programmed cell death

Journal of Experimental & Clinical Cancer Research, 2023
AbstractDisulfidptosis, a new form of cell death triggered by disulfide stress, is characterized by the collapse of cytoskeleton proteins and F-actin due to the intracellular accumulation of disulfides. This discovery will eventually aid in the development of therapeutic strategies against cancer.
Tingjin Zheng, Qingbo Liu, Feiyue Xing, Chong Zeng, Weidong Wang   +4 more
openaire   +3 more sources

Deadly actin collapse by disulfidptosis

Nature Cell Biology, 2023
Programmed cell death (PCD) enables cells to co-ordinate their exit to benefit the surviving organism. A new study describes how cells can programme their death by inducing extensive disulfide bonding of the actin cytoskeleton in response to an imbalance of cystine, a raw material for glutathione production.
openaire   +2 more sources

The expression and prognostic value of disulfidptosis progress in lung adenocarcinoma

Aging, 2023
Disulfidptosis is a new cell death model caused by accumulating intracellular disulfides bonding to actin cytoskeleton proteins. This study aimed to investigate the expression and prognostic value of disulfidptosis-related genes (DRGs) in lung adenocarcinoma (LUAD).
Ni, Lina, Yang, Huizhen, Wu, Xiaoyu, Zhou, Kejin, Wang, Sheng   +4 more
openaire   +2 more sources

Constructed Risk Prognosis Model Associated with Disulfidptosis lncRNAs in HCC

, 2023
Disulfidptosis is a novel cell death mode in which the accumulation of disulfide bonds in tumor cells leads to cell disintegration and death. Long-stranded noncoding RNAs (LncRNAs) are aberrantly expressed in hepatocellular carcinoma (HCC) and have been ...
Yijin Liu, Yiqi Wang, Xiao Jia, Yang Yang, Yueyue Fu   +4 more
core   +1 more source

A novel prognostic signature and immune microenvironment characteristics associated with disulfidptosis in papillary thyroid carcinoma based on single-cell RNA sequencing

Frontiers in Cell and Developmental Biology, 2023
Background: Disulfidptosis is a newly discovered form of regulated cell death. The research on disulfidptosis and tumor progression remains unclear.
Zhenyu Liao, Ye Cheng, Huiru Zhang, Xing Jin, Hanxing Sun, Yue Wang, Jiqi Yan   +6 more
doaj   +1 more source

A disulfidptosis-related lncRNA prognostic model to predict survival and response to immunotherapy in lung adenocarcinoma [PDF]

, 2023
Background: Lung adenocarcinoma (LUAD) is the major subtype of lung cancer and has a poor prognosis. Disulfidptosis is a novel regulated cell death form characterized by aberrant disulfide stress and actin network collapse.
Hai-Bo Zhang, Jian-Yan Pan, Tao Zhu
core   +1 more source

A bioinformatics approach to identify a disulfidptosis-related gene signature for prognostic implication in colon adenocarcinoma

Scientific Reports, 2023
Colon adenocarcinoma (COAD) is a type of cancer that arises from the glandular epithelial cells that produce mucus in the colon. COAD is influenced by various factors, including genetics, environment and lifestyle.
Gunchu Hu, Hongliang Yao, Zuxing Wei, Linye Li, Zhuowen Yu, Jian Li, Xiong Luo, Zhushu Guo   +7 more
doaj   +1 more source

A TMED3-governed disulfidptosis-related diagnostic signature reveals tumor microenvironment remodeling in intrahepatic cholangiocarcinoma. [PDF]

Front Immunol
Background Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with poor prognosis and limited treatment options. Disulfidptosis, a novel cell death pathway driven by disulfide bond accumulation, has
Qiao W, He Y, Li J, Liu X, Zhang L, Bai X, Wang Y, Tang J.   +7 more
europepmc   +2 more sources

Comprehensive analysis of disulfidptosis-related genes reveals the effect of disulfidptosis in ulcerative colitis

Scientific Reports
AbstractUlcerative colitis (UC) is a chronic inflammatory condition of the intestinal tract. Various programmed cell death pathways in the intestinal mucosa are crucial to the pathogenesis of UC. Disulfidptosis, a recently identified form of programmed cell death, has not been extensively reported in the context of UC.
Huixian Song, Fengrui Zhang, Xinyu Bai, Hao Liang, Junkun Niu, Yinglei Miao   +5 more
openaire   +3 more sources

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source