Results 51 to 60 of about 1,487 (157)

Exploration of the Role of M2 Macrophages in Hepatocellular Carcinoma: Insights into Disulfidptosis and Cellular Interactions

Frontiers in Bioscience-Landmark
Background: The interplay between regulated cell death processes, especially disulfidptosis, and the immune microenvironment in hepatocellular carcinoma (HCC) remains poorly understood.
Zhuming Chen, Weiwei Li, Anhai Yu, Wenkang Yuan, Songlin Xing, Jiale Chen, Shiwei Zhang, Xinyu Jiang, Zihao Du, Tingting Shen, Chao Zhang, Chong Zhang   +11 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, Volume 13, Issue 42, 28 July 2026.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration

Biology Direct
Background Limited supply of certain nutrients and deregulation of nucleus pulposus (NP) plays a key role in the pathogenesis of intervertebral disc degeneration (IVDD).
Shaobo Wu, Jin Wang, Minglin Wang, Kaisheng Zhou, Dageng Huang, Yilei Zhang, Haihong Zhang   +6 more
doaj   +1 more source

Disulfidptosis-related gene expression reflects the prognosis of drug-resistant cancer patients and inhibition of MYH9 reverses sorafenib resistance

Translational Oncology
The onset of drug resistance in advanced cancer patients markedly diminishes their prognosis. Recently, disulfidptosis, a novel form of cell death, has been identified, triggered by excessive disulfide formation leading to cell shrinkage and F-actin ...
Kangnan Zhang, Zhenhua Zhu, Jingyi Zhou, Min Shi, Na Wang, Fudong Yu, Ling Xu   +6 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis (Adv. Sci. 42/2026)

Advanced Science, Volume 13, Issue 42, 28 July 2026.
Zn‐Disulfidptosis‐Miscarriage This cover story is inspired from the classic Chinese myth “Nüwa Mends the Sky.” In this myth, meteorites (representing zinc ions) fall from the sky (representing from various environment), break the heavens (representing the upregulation of GATA1/METTL1/SLC7A11 signaling and cause of disulfidptosis), and subsequently ...
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, Volume 26, Issue 7, July 2026.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

Transcriptome and single-cell analysis reveal disulfidptosis-related modification patterns of tumor microenvironment and prognosis in osteosarcoma

Scientific Reports
Osteosarcoma (OS) is the most common malignant bone tumor with high pathological heterogeneity. Our study aimed to investigate disulfidptosis-related modification patterns in OS and their relationship with survival outcomes in patients with OS.
Linbang Wang, Yu Liu, Jiaojiao Tai, Xinyu Dou, Hongjuan Yang, Qiaochu Li, Jingkun Liu, Ziqiang Yan, Xiaoguang Liu   +8 more
doaj   +1 more source

From Cold to Hot: Nanozyme‐Based Strategies for Reprogramming the Tumour Immunoenvironment

Cell Proliferation, Volume 59, Issue 7, July 2026.
Nanozymes, with multi‐enzyme catalytic activities, reprogram the immunosuppressive tumour microenvironment by inducing immunogenic cell death, relieving hypoxia, and depleting antioxidants, effectively converting immunologically “cold” tumours into “hot” ones to boost cancer immunotherapy efficacy.
Yue Wang, Miao Xu, Yongshun Wang, Xuan Lin, Qiang Zhang, Xiaoning Lin, Xin Wu, Cheng Zhang, Wenhua Huang, Jianlin Shen   +9 more
wiley   +1 more source

Disulfidptosis: A New Target for Parkinson’s Disease and Cancer

Current Issues in Molecular Biology
Recent studies have uncovered intriguing connections between Parkinson’s disease (PD) and cancer, two seemingly distinct disease categories. Disulfidptosis has garnered attention as a novel form of regulated cell death that is implicated in various pathological conditions, including neurodegenerative disorders and cancer.
Tingting Liu, Xiangrui Kong, Jianshe Wei
openaire   +3 more sources

The role of molecular subtypes and immune infiltration characteristics based on disulfidptosis-related genes in ovarian cancer

Discover Oncology
Ovarian cancer (OC) is the most fatal, gynecological malignancy. Compared with advanced ovarian cancer, the 5 year survival rate of early ovarian cancer is significantly improved, and predicting early detection and diagnosis is very important to improve ...
Ruanruan Yang, Yating Wang, Zhifu Wei, Zhanpeng Huang, Xiaoshan Hong, Yu Lin   +5 more
doaj   +1 more source