Results 71 to 80 of about 1,487 (157)

Disulfidptosis signature predicts immune microenvironment and prognosis of gastric cancer

Biology Direct
Background Disulfidptosis is a newly identified mechanism of cell death triggered by disulfide stress. Thus, gaining a comprehensive understanding of the disulfidptosis signature present in gastric cancer (GC) could greatly enhance the development of ...
Zitao Liu, Liang Sun, Wenjie Zhu, Jinfeng Zhu, Changlei Wu, Xingyu Peng, Huakai Tian, Chao Huang, Zhengming Zhu   +8 more
doaj   +1 more source

Disulfidptosis contributes to rotenone-induced dopaminergic neuron damage

Neural Regeneration Research
Parkinson's disease is a neurodegenerative disorder whose pathogenesis remains incompletely understood. Rotenone exposure is reportedly associated with Parkinson's disease. In addition, disulfidptosis is a newly identified form of cell death. Interestingly, an analysis of the Gene Expression Omnibus Parkinson's disease database indicated that ...
Wenqi Ye, Qifu Zhang, Wei Ge, Haoyin Liu, Yaohui Shan, Feng Ye, Xiaogang Wang, Yuanpeng Zhao, Guorong Dan, Mingliang Chen, Yan Sai   +10 more
openaire   +2 more sources

Development of a disulfidptosis-related prognostic model for endometrial cancer with potential therapeutic target

Discover Oncology
Prognosis biomarkers for endometrial cancer (EC) are in need. Recent evidence demonstrated the critical role of disulfidptosis, a novel cell death modality, in cancer.
Chunmei Li, Xuefei Fan, Xue Wang, Yulan Yao, Bing Huang, Linlin Chen, Lu Cao, Tao Peng, Yingying Lin, Rong Cai   +9 more
doaj   +1 more source

The involvement of lncRNA EMSLR in the disulfidptosis and progression of endometrial carcinoma

Cancer Gene Therapy
The incidence of endometrial cancer (EC) continues to rise. Disulfidptosis, a novel form of cell death, may represent a potential therapeutic target in EC. Through bioinformatic analysis of The Cancer Genome Atlas (TCGA) database, E2F1 mRNA-stabilizing lncRNA (EMSLR) was identified as a lncRNA related to disulfidptosis in EC.
Yixuan Sun, Ruiwen Wang, Xinzhu Li, Wanzhen Zhou, Huixian Huang, Yang Zhou, Xiaolu Zhu, Yifan Yin, Yincheng Teng   +8 more
openaire   +2 more sources

Disulfidptosis-related subtype and prognostic signature in prostate cancer

Biology Direct
Disulfidptosis refers to cell death caused by the accumulation and bonding of disulfide in the cytoskeleton protein of SLC7A11-high level cells under glucose deprivation. However, the role of disulfidptosis-related genes (DRGs) in prostate cancer (PCa) classification and regulation of the tumor microenvironment remains unclear.Firstly, we analyzed the ...
Zhen Kang, Zheng-Hua Wan, Rui-Cheng Gao, Dong-Ning Chen, Qing-Shui Zheng, Xue-Yi Xue, Ning Xu, Yong Wei   +7 more
openaire   +3 more sources

FLNA, a disulfidptosis-related gene, modulates tumor immunity and progression in colorectal cancer

Cellular & Molecular Biology Letters
Background Disulfidptosis represents a novel type of regulated cell death induced by excessively high intracellular levels of cystine. Targeting disulfide imbalance is considered a promising treatment approach for colorectal cancer (CRC).
Qiong Li, Renhong Huang, Lingling Lv, Haifeng Ying, Yuan Wu, YuQing Huang, Yuxi Li, Wen Ma, Xiaoshuang Liu, Qinghui Meng, Fengying Xing, Yan Shen, Lan Zheng   +12 more
doaj   +1 more source

Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels

Oncogenesis
BAP1, BRCA1-Associated Protein 1, serves as a novel tumor suppressor through the deubiquitination of monoubiquitination of H2A and subsequent gene transcriptional regulation.
Jin Wang, Minglin Wang, Shaobo Wu, Yanan Zhu, Kexin Fan, Yuhan Chen, Zhengtao Xiao, Jing Chen, Kangsheng Tu, Dongsheng Huang, Yilei Zhang, Qiuran Xu   +11 more
doaj   +1 more source

Comprehensive evaluation of disulfidptosis in intestinal immunity and biologic therapy response in Ulcerative Colitis

Heliyon
Objective: Ulcerative Colitis (UC) manifests as a chronic inflammatory condition of the intestines, marked by ongoing immune system dysregulation. Disulfidptosis, a newly identified cell death mechanism, is intimately linked to the onset and advancement ...
Lichao Yang, Lianwen Yuan, Ganglei Liu
doaj   +1 more source

CD2AP is a disulfidptosis modulator and prognostic biomarker in hepatocellular carcinoma

Clinical and Experimental Medicine
CD2-associated protein (CD2AP) is an adapter protein that stabilizes the actin cytoskeleton and is closely linked to disulfidptosis. However, its functional role in hepatocellular carcinoma (HCC) progression and disulfidptosis remains undefined. Herein, pan-cancer multiomics analyses were performed on 33 malignancies from The Cancer Genome Atlas (TCGA)
Tan, Yingzheng, Yang, Lei, Wang, Qingbin, Huang, Meiyuan, Yi, Bo, Wan, Jian, Xu, Tao, Zhao, Zhijian, Tang, Caixi, Xie, Yang, Chen, Xun, Tan, Wenliang   +11 more
openaire   +3 more sources

CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis

Journal of Experimental & Clinical Cancer Research
Purpose Glucose starvation induces the accumulation of disulfides and F-actin collapse in cells with high expression of SLC7A11, a phenomenon termed disulfidptosis.
Hong-Fei Yao, Jieqiong Ge, Jiahao Chen, Xiaoyan Tang, Chunjing Li, Xiao Hu, Abousalam Abdoulkader Ahmed, Yunlong Pu, Guihua Zhou, Tongyi Zhang, Zhiwei Cai, Chongyi Jiang   +11 more
doaj   +1 more source