Results 91 to 100 of about 2,022 (185)

Identifying disulfidptosis subtypes in hepatocellular carcinoma through machine learning and preliminary exploration of its connection with immunotherapy

Cancer Cell International
Background Hepatocellular carcinoma (HCC) is a highly prevalent and deadly cancer, with limited treatment options for advanced-stage patients. Disulfidptosis is a recently identified mechanism of programmed cell death that occurs in SLC7A11 high ...
Guanjun Chen, Ganghua Zhang, Yuxing Zhu, Anshan Wu, Jianing Fang, Zhijing Yin, Haotian Chen, Ke Cao   +7 more
doaj   +1 more source

FLNA, a disulfidptosis-related gene, modulates tumor immunity and progression in colorectal cancer

Cellular & Molecular Biology Letters
Background Disulfidptosis represents a novel type of regulated cell death induced by excessively high intracellular levels of cystine. Targeting disulfide imbalance is considered a promising treatment approach for colorectal cancer (CRC).
Qiong Li, Renhong Huang, Lingling Lv, Haifeng Ying, Yuan Wu, YuQing Huang, Yuxi Li, Wen Ma, Xiaoshuang Liu, Qinghui Meng, Fengying Xing, Yan Shen, Lan Zheng   +12 more
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Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels

Oncogenesis
BAP1, BRCA1-Associated Protein 1, serves as a novel tumor suppressor through the deubiquitination of monoubiquitination of H2A and subsequent gene transcriptional regulation.
Jin Wang, Minglin Wang, Shaobo Wu, Yanan Zhu, Kexin Fan, Yuhan Chen, Zhengtao Xiao, Jing Chen, Kangsheng Tu, Dongsheng Huang, Yilei Zhang, Qiuran Xu   +11 more
doaj   +1 more source

Disulfidptosis-related subtype and prognostic signature in prostate cancer

Biology Direct
Disulfidptosis refers to cell death caused by the accumulation and bonding of disulfide in the cytoskeleton protein of SLC7A11-high level cells under glucose deprivation. However, the role of disulfidptosis-related genes (DRGs) in prostate cancer (PCa) classification and regulation of the tumor microenvironment remains unclear.Firstly, we analyzed the ...
Zhen Kang, Zheng-Hua Wan, Rui-Cheng Gao, Dong-Ning Chen, Qing-Shui Zheng, Xue-Yi Xue, Ning Xu, Yong Wei   +7 more
openaire   +3 more sources

Development of a disulfidptosis-related prognostic model for endometrial cancer with potential therapeutic target

Discover Oncology
Prognosis biomarkers for endometrial cancer (EC) are in need. Recent evidence demonstrated the critical role of disulfidptosis, a novel cell death modality, in cancer.
Chunmei Li, Xuefei Fan, Xue Wang, Yulan Yao, Bing Huang, Linlin Chen, Lu Cao, Tao Peng, Yingying Lin, Rong Cai   +9 more
doaj   +1 more source

Role of Disulfidptosis in the Local Inflammatory Response of Atopic Dermatitis

Clinical and Translational Allergy
Background Understanding cell death pathways is critical for elucidating the mechanisms underlying inflammation in atopic dermatitis (AD). This study investigates the role of disulfidptosis, a novel form of programmed cell death, in AD pathogenesis ...
Dong‐Mei Zhou, Cheng Chen, Yuan‐Fen Liao, Xi‐Meng Ma, Xin‐Hui Gong, Cheng‐Jun Cui, Yu‐Bao Cui   +6 more
doaj   +1 more source

CD2AP is a disulfidptosis modulator and prognostic biomarker in hepatocellular carcinoma

Clinical and Experimental Medicine
CD2-associated protein (CD2AP) is an adapter protein that stabilizes the actin cytoskeleton and is closely linked to disulfidptosis. However, its functional role in hepatocellular carcinoma (HCC) progression and disulfidptosis remains undefined. Herein, pan-cancer multiomics analyses were performed on 33 malignancies from The Cancer Genome Atlas (TCGA)
Tan, Yingzheng, Yang, Lei, Wang, Qingbin, Huang, Meiyuan, Yi, Bo, Wan, Jian, Xu, Tao, Zhao, Zhijian, Tang, Caixi, Xie, Yang, Chen, Xun, Tan, Wenliang   +11 more
openaire   +3 more sources

The role of disulfidptosis-driven tumor microenvironment remodeling in pancreatic cancer progression

Frontiers in Immunology
BackgroundPancreatic ductal adenocarcinoma (PDAC) continues to pose a significant clinical challenge due to its high mortality rate and limited treatment efficacy.
Wenhao Li, Jiewen Deng, Hao Zhang, Menghan Zhang, Chuanxu Kang, Zicheng Yu, Yunshen Gu, Xiaobo He, Yanfeng Wu   +8 more
doaj   +1 more source

Role of disulfidptosis in colorectal adenocarcinoma: implications for prognosis and immunity

Frontiers in Immunology
BackgroundRecent research has found a new way of cell death: disulfidptosis. Under glucose starvation, abnormal accumulation of disulfide molecules such as Cystine in Solute Carrier Family 7 Member 11 (SLC7A11) overexpression cells induced disulfide stress to trigger cell death.
Ruanruan Yang, Chunxiao Lai, Luji Huang, Feng Li, Weiqi Peng, Meiyan Wu, Jinge Xin, Yan Lu, Manzhao Ouyang, Yang Bai, Haoqiang Lei, Shunhui He, Yu Lin   +12 more
openaire   +3 more sources

Disulfidptosis: a novel cell death modality induced by actin cytoskeleton collapse and a promising target for cancer therapeutics

Cell Communication and Signaling
Disulfidptosis is a novel discovered form of programmed cell death (PCD) that diverges from apoptosis, necroptosis, ferroptosis, and cuproptosis, stemming from disulfide stress-induced cytoskeletal collapse.
Tianyi Li, Ying Song, Lijuan Wei, Xiangyi Song, Ruifeng Duan   +4 more
doaj   +1 more source