Results 101 to 110 of about 2,022 (185)

BHLHE41–SLC7A11 transcriptional axis and chromatin remodeling signatures in osteogenic-lineage disulfidptosis-like stress in osteoporosis

Frontiers in Genetics
BackgroundOsteoporosis (OP) is characterized by impaired bone homeostasis in which bone resorption exceeds bone formation. Disulfidptosis, a recently described disulfide stress–induced cell death program linked to cytoskeletal collapse, has been ...
Xiaoming Zhao, Wenya Xue, Jun Gao, Yilei Zhang, Jinghong Chen, Yingang Zhang, Song Long   +6 more
doaj   +1 more source

Suppression of the disulfidptosis ameliorates NiONPs-induced collagen deposition by hsa_circ_0007702/miR-181d-5p/SLC7A11 axis

Nickel oxide nanoparticles (NiONPs) are known to induce pulmonary fibrosis and its mechanism remain incompletely understood. This study focused on the mechanism of hsa_circ_0007702-down-regulating miR-181d-5p mediated SLC7A11, then inhibited ...
Yingbiao Sun, Hui Wang, Yuting Li, Yanqiu Jiang, Sheng Li, Xuhong Chang, Hongjun Zhao, Haodong Zhou, Jinxia Gao, Lijiao Ma   +9 more
core   +1 more source

Ischemic Postconditioning Regulates New Cell Death Mechanisms in Stroke: Disulfidptosis

Background and Objective: Stroke poses a critical health issue without effective neuroprotection. We explore ischemic postconditioning’s (IPostC) potential to mitigate stroke-induced brain injury, focusing on its interaction with disulfidptosis, a ...
Cuiying Liu, Can Xu, Heng Zhao, Liping Wang, Jialing Wang, Qike Wu, Shanpeng Liu   +6 more
core   +1 more source

Development and validation of a disulfidptosis-related genes signature for predicting outcomes and immunotherapy in acute myeloid leukemia [PDF]

BackgroundAcute myeloid leukemia (AML) is a hematopoietic malignancy with poor outcomes and high recurrence. Disulfidptosis, a novel form of programmed cell death driven by aberrant disulfide bonds and F-actin collapse, provides insights into cancer ...
Mingwei Wang, Ling Li, Jing Liu, Han Gong, Ying Zhang, Xusheng Wu, Xiaofeng He, Yiming Pan, Zhong Liu   +8 more
core   +1 more source

CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis

Journal of Experimental & Clinical Cancer Research
Purpose Glucose starvation induces the accumulation of disulfides and F-actin collapse in cells with high expression of SLC7A11, a phenomenon termed disulfidptosis.
Hong-Fei Yao, Jieqiong Ge, Jiahao Chen, Xiaoyan Tang, Chunjing Li, Xiao Hu, Abousalam Abdoulkader Ahmed, Yunlong Pu, Guihua Zhou, Tongyi Zhang, Zhiwei Cai, Chongyi Jiang   +11 more
doaj   +1 more source

Prognostic model based on disulfidptosis-related lncRNAs for predicting survival and therapeutic response in bladder cancer [PDF]

BackgroundWith poor treatment outcomes and prognosis, bladder cancer remains a focus for clinical research in the precision oncology era. However, the potential of disulfidptosis, a novel cell death mechanism, and its related long non-coding RNAs to ...
Xuan Jiang, Hankai Yang, Chang Ge, Ziyu Zhou, Yubo Liu, Wei Wang, Kairan Yu, Guofang Li, Lirui Han   +8 more
core   +1 more source

Identification and validation of differentially expressed disulfidptosis-related genes in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is one of the most common cardiovascular diseases with no effective treatment due to its complex pathogenesis.
Shuai Xu, Xulong Ding, Jili Fan, Runze Zhao, Xin Tan, Peng Zhou, Huimin Fan, Xiaohong Bo, Yangjun Fu, Yiyao Zeng, Hailong Zhang, Yafeng Zhou, Tong Shao   +12 more
core   +1 more source

DataSheet_1_Integrative analysis of disulfidptosis and immune microenvironment in hepatocellular carcinoma: a putative model and immunotherapeutic strategies.pdf

BackgroundHepatocellular carcinoma (HCC) is a malignant tumor with a high rate of recurrence and m metastasis that does not respond well to current therapies and has a very poor prognosis.
Peifeng Ke (6855746), Junhao Liu (9250731), Jianfan Wen (4987586), Zengxin Ma (14498550), Yifeng He (563263), Siliang Chen (9101296), Qiaolan Yang (5877050), Juan Duan (144000), Ti Yang (16027271), Jiashun Lei (17722641), Fang Liu (13271), Xiancheng Zeng (470954)   +11 more
core   +1 more source

Unveiling disulfidptosis-related biomarkers and predicting drugs in Alzheimer’s disease

Scientific Reports
Alzheimer's disease is the predominant form of dementia, and disulfidptosis is the latest reported mode of cell death that impacts various disease processes. This study used bioinformatics to analyze genes associated with disulfidptosis in Alzheimer's disease comprehensively.
Lei Huang, Zhengtai Li, Yitong Lv, Xinyun Zhang, Yifan Li, Yingji Li, Changyuan Yu   +6 more
openaire   +3 more sources

Disulfidptosis modification patterns are involved in the immune microenvironment regulation of septic acute respiratory distress syndrome [PDF]

Disulfidptosis is a new form of programmed cell death. However, there is limited information available regarding the impact of disulfidptosis on septic acute respiratory distress syndrome (ARDS).
Ge, Junke, Junke Ge, Zhang, Qian, Qian Zhang   +3 more
core   +1 more source