Results 61 to 70 of about 1,487 (157)

Disulfidptosis: Mechanisms, evidence boundaries, and translational opportunities

Redox Biology
Disulfidptosis has rapidly emerged as a regulated cell death mechanism linked to cystine stress, aberrant disulfide accumulation, and collapse of the actin cytoskeleton, particularly in contexts shaped by high SLC7A11 activity and impaired NADPH ...
Rongqing Li, Jiahui Wang, Wei Li, Li Qian   +3 more
doaj   +1 more source

Ferroptosis in breast cancer: From adipocyte–immune–iron regulation to therapeutic application

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Ferroptosis in breast cancer is regulated by an integrated adipocyte–immune–iron network rather than by tumour‐intrinsic pathways alone. Adipocyte‐derived lipid substrates and redox metabolites, immune‐cell‐mediated cytokine signalling and iron‐dependent oxidative stress collectively shape a dynamic ferroptosis ecosystem that can shift tumours towards ...
Juan Sun, Yang Qu, Ru Yao, Yidong Zhou
wiley   +1 more source

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, Volume 5, Issue 3, June 2026.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Identification of disulfidptosis-related clusters and construction of a disulfidptosis-related gene prognostic signature in triple-negative breast cancer

Heliyon
This study aimed to explore disulfidptosis-related clusters of triple-negative breast cancer (TNBC) and build a reliable disulfidptosis-related gene signature for forecasting TNBC prognosis.The disulfidptosis-related clusters of TNBC were identified based on public datasets, and a comparative analysis was conducted to assess their differences in the ...
Jie Wu, Yan Cai, Gaiping Zhao
openaire   +3 more sources

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Exploring the role of Disulfidptosis in glioma progression: insights into tumor heterogeneity and therapeutic potential through single-cell RNA sequencing

Discover Oncology
Background Gliomas, particularly glioblastoma (GBM), are the most common and aggressive primary brain tumors in adults, characterized by high malignancy and frequent recurrence.
Xiaorong Fan, Maojun Chen
doaj   +1 more source

Disulfidptosis in pediatric AML: a multi-omics approach to risk stratification and potential therapeutic strategy

Cancer Cell International
Background The evolving molecular portrait of acute myeloid leukemia (AML) has exposed previously unrecognized cell death programs that fuel disease progression and treatment resistance—uncovering untapped therapeutic potential. Recent work has uncovered
Yichen Lei, Jiasi Zhang, Yaqin Wang, Aiguo Liu   +3 more
doaj   +1 more source

Targeting Disulfidptosis with Potentially Bioactive Natural Products in Metabolic Cancer Therapy

Metabolites
Background: Metabolic cancers are defined by metabolic reprogramming. Although this reprograming drives rapid tumour growth and invasion, it also reveals specific metabolic vulnerabilities that can be therapeutically exploited in cancer therapy.
Xinyan Li, Jiayi Xu, Liangwen Yan, Shenkang Tang, Yinggang Zhang, Mengjiao Shi, Pengfei Liu   +6 more
doaj   +1 more source

Diagnostic and prognostic value of disulfidptosis-related genes in sepsis

Infectious Medicine
Sepsis is a disease associated with high morbidity and mortality rates, especially among the elderly and patients in intensive care units. Disulfidptosis, a newly identified form of cell death triggered by disulfide stress, is emerging as a significant factor in disease progression.
Wenlu Zou, Lintao Sai, Wen Sai, Li Song, Gang Wang   +4 more
openaire   +3 more sources

Identifying disulfidptosis subtypes in hepatocellular carcinoma through machine learning and preliminary exploration of its connection with immunotherapy

Cancer Cell International
Background Hepatocellular carcinoma (HCC) is a highly prevalent and deadly cancer, with limited treatment options for advanced-stage patients. Disulfidptosis is a recently identified mechanism of programmed cell death that occurs in SLC7A11 high ...
Guanjun Chen, Ganghua Zhang, Yuxing Zhu, Anshan Wu, Jianing Fang, Zhijing Yin, Haotian Chen, Ke Cao   +7 more
doaj   +1 more source