Results 61 to 70 of about 2,022 (185)

The Mechanism and Regulation of Disulfidptosis and Its Role in Disease

Biomedicines
Disulfidptosis is a recently identified form of regulatory cell death (RCD), Which has emerged as a research hotspot due to its distinctive feature of accumulating protein disulfide bonds, setting it apart from other RCD mechanisms. This discovery may offer new therapeutic strategies for cancer and various chronic diseases.
Yiming Wan, Mengjia Jing, Lumiao Zhang, Qianben Song, Xilin Ye, Zhenzhen Zhou, Wei Yan, Yu Fu   +7 more
openaire   +2 more sources

Rab11a-dependent recycling of Glut3 inhibits seizure-induced neuronal disulfidptosis by alleviating glucose deficiency

Cell & Bioscience
Seizures can trigger neuronal glucose deficiency, thereby inducing disulfidptosis. Disulfidptosis is a novel cell death mechanism characterized by the abnormal accumulation of disulfide caused by glucose deficiency.
Sijun Li, Junrui He, Huimin Kuang, Xiaojuan Wang, Muhua Zhou, Dongmei Li, Baoren Kang, Honghu He, Lina He, Wei Lin, Yuan Lv   +10 more
doaj   +1 more source

Exploration of the Role of M2 Macrophages in Hepatocellular Carcinoma: Insights into Disulfidptosis and Cellular Interactions

Frontiers in Bioscience-Landmark
Background: The interplay between regulated cell death processes, especially disulfidptosis, and the immune microenvironment in hepatocellular carcinoma (HCC) remains poorly understood.
Zhuming Chen, Weiwei Li, Anhai Yu, Wenkang Yuan, Songlin Xing, Jiale Chen, Shiwei Zhang, Xinyu Jiang, Zihao Du, Tingting Shen, Chao Zhang, Chong Zhang   +11 more
doaj   +1 more source

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, Volume 2, Issue 3, September 2026.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

RPN1: a pan-cancer biomarker and disulfidptosis regulator

Translational Cancer Research
Elevated expression of SLC7A11, in conjunction with glucose deprivation, has revealed disulfidptosis as an emerging cell death modality. However, the prevalence of disulfidptosis across tumor cell lines, irrespective of SLC7A11 levels, remains uncertain.
Wang, Xing, Zhu, Hong-Quan, Lin, Shi-Ming, Xia, Bao-Ying, Xu, Bo   +4 more
openaire   +2 more sources

Disulfidptosis-related gene expression reflects the prognosis of drug-resistant cancer patients and inhibition of MYH9 reverses sorafenib resistance

Translational Oncology
The onset of drug resistance in advanced cancer patients markedly diminishes their prognosis. Recently, disulfidptosis, a novel form of cell death, has been identified, triggered by excessive disulfide formation leading to cell shrinkage and F-actin ...
Kangnan Zhang, Zhenhua Zhu, Jingyi Zhou, Min Shi, Na Wang, Fudong Yu, Ling Xu   +6 more
doaj   +1 more source

ATF4/SCO2 Inhibits Ferroptosis in Lung Cancer Through Activating the MAPK Signaling Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ATF4 activates the transcription of SCO2 to increase SCO2 expression that further stimulates p38/ERK1 signals in MAPK pathway, ultimately promoting proliferation and migration while inhibiting apoptosis and ferroptosis of lung cancer cells. ABSTRACT Ferroptosis is a specific cell death form resulting from the iron‐dependent lipid peroxidation ...
Liang Yu, Sheng Zhang, Jinxi He, Bo Ma, Xuyang Song, Rui Qiu, Bo Yu   +6 more
wiley   +1 more source

Glucose Transporter 1 in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai, Zhihao Chen, Yuping Zhu, Weidong Han   +3 more
wiley   +1 more source

Disulfidptosis: A New Target for Parkinson’s Disease and Cancer

Current Issues in Molecular Biology
Recent studies have uncovered intriguing connections between Parkinson’s disease (PD) and cancer, two seemingly distinct disease categories. Disulfidptosis has garnered attention as a novel form of regulated cell death that is implicated in various pathological conditions, including neurodegenerative disorders and cancer.
Tingting Liu, Xiangrui Kong, Jianshe Wei
openaire   +3 more sources

Transcriptome and single-cell analysis reveal disulfidptosis-related modification patterns of tumor microenvironment and prognosis in osteosarcoma

Scientific Reports
Osteosarcoma (OS) is the most common malignant bone tumor with high pathological heterogeneity. Our study aimed to investigate disulfidptosis-related modification patterns in OS and their relationship with survival outcomes in patients with OS.
Linbang Wang, Yu Liu, Jiaojiao Tai, Xinyu Dou, Hongjuan Yang, Qiaochu Li, Jingkun Liu, Ziqiang Yan, Xiaoguang Liu   +8 more
doaj   +1 more source