Results 31 to 40 of about 1,487 (157)

Disulfidptosis-associated lncRNAs predict breast cancer subtypes

Scientific Reports, 2023
Abstract Background Disulfidptosis is a newly discovered mode of cell death. However, its relationship with breast cancer subtypes remains unclear. In this study, we aimed to construct a disulfidptosis-associated breast cancer subtype prediction model.
Qing Xia, Qibin Yan, Zehua Wang, Qinyuan Huang, Xinying Zheng, Jinze Shen, Lihua Du, Hanbing Li, Shiwei Duan   +8 more
openaire   +3 more sources

Comprehensive analysis of disulfidptosis-related genes reveals the effect of disulfidptosis in ulcerative colitis

Scientific Reports
AbstractUlcerative colitis (UC) is a chronic inflammatory condition of the intestinal tract. Various programmed cell death pathways in the intestinal mucosa are crucial to the pathogenesis of UC. Disulfidptosis, a recently identified form of programmed cell death, has not been extensively reported in the context of UC.
Huixian Song, Fengrui Zhang, Xinyu Bai, Hao Liang, Junkun Niu, Yinglei Miao   +5 more
openaire   +3 more sources

Establishment of disulfidptosis-related LncRNA signature as biomarkers in colon adenocarcinoma

Cancer Cell International
Purpose Metabolic reprogramming is a hallmark of cancer and plays a key role in precision oncology treatment. Long non-coding RNAs (lncRNAs) regulate cancer cell behavior, including metabolism.
Hongfei Yao, Peng Liu, Linli Yao, Xiao Li   +3 more
doaj   +1 more source

Tumor Microenvironment‐Responsive Nanoreactor Induces Disulfidptosis in Pancreatic Cancer via Metabolic Interference and Redox Catalysis

Advanced Science, EarlyView.
Schematic illustration of a tumor microenvironment‐responsive nanoreactor for imaging‐guided induction of disulfidptosis in pancreatic cancer via metabolic interference and redox catalysis. (A) Stepwise fabrication of Pht@HMnO2‐HA, including MnO2 growth on a SiO2 template, template removal to form hollow mesoporous MnO2, Pht loading, and subsequent ...
Rui Fu, Qing Li, Guanzhong Zhao, Qingyan Gao, Huantong Chen, Khemayanto Hidayat, Jiaying Xu, Liqiang Qin, Chunhong Hu, Yu Chong, Su Hu   +10 more
wiley   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, EarlyView.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Disulfidptosis: Six Riddles Necessitating Solutions

International Journal of Biological Sciences
Disulfidptosis occurs as a result of the accumulation of intracellular cystine followed by disulfide stress in actin cytoskeleton proteins due to a reduction of NADPH produced through the pentose phosphate pathway in cells with high expression of SLC7A11.
Wang, Xinyu, Zheng, Chanjuan, Yao, Hui, Guo, Yuxuan, Wang, Yian, He, Guangchun, Fu, Shujun, Deng, Xiyun   +7 more
openaire   +2 more sources

Preliminary findings on the development of a predictive model for BLCA based on disulfidptosis-associated IncRNAs signature

BMC Urology
Background Bladder urothelial carcinoma (BLCA) is the most common malignancy of the urinary tract, presenting with a wide range of clinical symptoms and prognosis.
Chao Tang, Yanpeng Fan, Shusheng Zhu
doaj   +1 more source