Results 31 to 40 of about 2,022 (185)

Disulfidptosis: a new target for central nervous system disease therapy

Frontiers in Neuroscience
Disulfidptosis is a pathologic process that occurs under conditions of NADPH deficiency and excess disulfide bonds in cells that express high levels of SLC7A11.
Jun Liao, Danhong Liu, Yuqi Xiao
exaly   +3 more sources

Identification and validation of a disulfidptosis-related genes prognostic signature in lung adenocarcinoma

Heliyon
Disulfidptosis, a newly revealed form of cell death, regulated by numerous genes that has been recently identified. The exact role of disulfidptosis in lung adenocarcinoma (LUAD) still uncertain.
Yanpeng Zhang, Jingyang Sun, Meng Li, Liren Hou, Zhiyu Wang, Huanhuan Dong, Wenjun Xu, Rongxuan Jiang, Yuhan Geng, Chungen Guan, Zijiang Zhu, Hongyi Wang, Qiuyu Gong, Guangjian Zhang   +13 more
doaj   +2 more sources

Identification of RPL4 as a biomarker associated with disulfidptosis and arachidonic acid metabolism in breast cancer [PDF]

Discover Oncology
Objective Disulfidptosis is a recently discovered mechanism of cell death caused by disulfide stress. Arachidonic acid metabolism (AAM) is one of the metabolic mechanisms of polyunsaturated fatty acids. However, few studies have explored the relationship
Tao Yan, Bolin Yu, Fengyuan Qian, Lin Fang, Yuanyuan Zhao, Danrong Ye   +5 more
doaj   +2 more sources

Integrated spatial and single‑cell transcriptomics maps disulfidptosis in renal cell carcinoma and reveals PDLIM1 as a prognostic biomarker and potential therapeutic target [PDF]

Translational Oncology
Background: Disulfidptosis is a regulated cell death program linked to redox stress, metabolism, and the actin cytoskeleton. Its organization in tissue and clinical relevance in renal cell carcinoma are not well defined.
Wenqiang Liu, Xianglin Liu, Juan Yi, Zhao Tang, Ziwen Dai, Jiaao Song, Tong Chen, Jun Wang, Jiaxuan Wang, Wentao Jiang, Aimin Jiang, Zhenjie Wu, Lifang Tang, Yuming Jin, Yinghu Chen, Linhui Wang   +15 more
doaj   +2 more sources

Disulfidptosis as a key regulator of glioblastoma progression and immune cell impairment

Frontiers in Immunology
BackgroundGlioblastoma, associated with poor prognosis and impaired immune function, shows potential interactions between newly identified disulfidptosis mechanisms and T cell exhaustion, yet these remain understudied.MethodsKey genes were identified ...
Yifu Shu, Jing Li
exaly   +3 more sources

Provoking tumor disulfidptosis by single-atom nanozyme via regulating cellular energy supply and reducing power

Nature Communications
Disulfidptosis, a recently identified form of programmed cell death, is initiated by depletion of endogenous nicotinamide adenine dinucleotide phosphate (NADPH) under glucose starvation.
Wenxin Yu, Duo Jin, Yajie Zhang, Shenghu Wang, Jiaji Yu, Manman Liu, Yi Dai, Yichen Yin, Junjie Cheng, Yangzhong Liu   +9 more
doaj   +2 more sources

PPARγ Antagonists Exhibit Antitumor Effects by Regulating Ferroptosis and Disulfidptosis

Biomolecules
Oral squamous cell carcinoma (OSCC) stands as a prevalent subtype of head and neck squamous cell carcinoma, leading to disease recurrence and low survival rates. PPARγ, a ligand-dependent nuclear transcription factor, holds significance in tumor development. However, the role of PPARγ in the development of OSCC has not been fully elucidated.
Shiyu Zhang, Ying Wang, Junjie Gu, Yang Yang, Jing Liang, Yimei Wang, Ning Ji, Ming Liu, Yingxin Zhang, Silu Sun, Qianming Chen, Jing Li   +11 more
openaire   +4 more sources

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science
Disulfidptosis, a novel form of regulated cell death, involves cytoskeletal collapse due to excessive disulfide bond formation, linking metabolism and reactive oxygen species to potential cancer therapy targets.
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
doaj   +2 more sources

Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility

Advanced Science
Disulfidptosis, a newly identified form of programmed cell death, has emerged as a promising therapeutic target for tumors. However, the current research in this field is hindered by the absence of precise and quantifiable biomarkers to accurately ...
Congcong Zhang, Xiangdi Zhang, Shushen Li, Yuyang Li, Bei Yuan, Mingshuang Zheng, Shuo Zhang, Fangping Yuan, Min Jia, Lixia Lu, Jun Zhou, Zhenguo Zhang, Xin Du   +12 more
doaj   +2 more sources

Experimental Detection Methods and Clinical Translational Challenges of Disulfidptosis in Cancer. [PDF]

Cells
Disulfidptosis was originally characterized as a programmed cell death modality reliant on SLC7A11 overexpression, which ultimately induces cytoskeleton collapse.
Han T, Li R, Wang J, Chu Y, Cai L.
europepmc   +2 more sources