Results 21 to 30 of about 1,487 (157)

Disulfidptosis: a new form of programmed cell death

Journal of Experimental & Clinical Cancer Research, 2023
AbstractDisulfidptosis, a new form of cell death triggered by disulfide stress, is characterized by the collapse of cytoskeleton proteins and F-actin due to the intracellular accumulation of disulfides. This discovery will eventually aid in the development of therapeutic strategies against cancer.
Tingjin Zheng, Qingbo Liu, Feiyue Xing, Chong Zeng, Weidong Wang   +4 more
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Deadly actin collapse by disulfidptosis

Nature Cell Biology, 2023
Programmed cell death (PCD) enables cells to co-ordinate their exit to benefit the surviving organism. A new study describes how cells can programme their death by inducing extensive disulfide bonding of the actin cytoskeleton in response to an imbalance of cystine, a raw material for glutathione production.
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Identification of disulfidptosis-related genes and subgroups in Alzheimer’s disease

Frontiers in Aging Neuroscience, 2023
BackgroundAlzheimer’s disease (AD), a common neurological disorder, has no effective treatment due to its complex pathogenesis. Disulfidptosis, a newly discovered type of cell death, seems to be closely related to the occurrence of various diseases. In this study, through bioinformatics analysis, the expression and function of disulfidptosis-related ...
Shijia Ma, Dan Wang, Daojun Xie
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Cuproptosis and Disulfidptosis Converge to Empower PD-L1 Checkpoint Therapy via Cadict-Induced PD-L1 Translation. [PDF]

Adv Sci (Weinh)
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Huang S, Song S, Zhang X, Gao J, Pu R, Dai J, Wu X, Chen L, Li Q, Liu X, Zhou Q, Song M, He W.   +12 more
europepmc   +2 more sources

The expression and prognostic value of disulfidptosis progress in lung adenocarcinoma

Aging, 2023
Disulfidptosis is a new cell death model caused by accumulating intracellular disulfides bonding to actin cytoskeleton proteins. This study aimed to investigate the expression and prognostic value of disulfidptosis-related genes (DRGs) in lung adenocarcinoma (LUAD).
Ni, Lina, Yang, Huizhen, Wu, Xiaoyu, Zhou, Kejin, Wang, Sheng   +4 more
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Disulfidptosis and its emerging relevance in cancer and immunity. [PDF]

Ferroptosis Oxid Stress
Disulfidptosis is a recently identified form of regulated cell death (RCD) triggered by disulfide stress when cystine uptake via solute carrier family 7 member 1 (SLC7A11) overwhelms the cell’s reducing capacity. Unlike apoptosis or other “cell suicide” pathways, disulfidptosis likely represents a “cell sabotage” mechanism, defined by aberrant ...
Li Q, Wu S, Zhuang L, Gan B.
europepmc   +4 more sources

A bioinformatics approach to identify a disulfidptosis-related gene signature for prognostic implication in colon adenocarcinoma

Scientific Reports, 2023
Colon adenocarcinoma (COAD) is a type of cancer that arises from the glandular epithelial cells that produce mucus in the colon. COAD is influenced by various factors, including genetics, environment and lifestyle.
Gunchu Hu, Hongliang Yao, Zuxing Wei, Linye Li, Zhuowen Yu, Jian Li, Xiong Luo, Zhushu Guo   +7 more
doaj   +1 more source

A novel prognostic signature and immune microenvironment characteristics associated with disulfidptosis in papillary thyroid carcinoma based on single-cell RNA sequencing

Frontiers in Cell and Developmental Biology, 2023
Background: Disulfidptosis is a newly discovered form of regulated cell death. The research on disulfidptosis and tumor progression remains unclear.
Zhenyu Liao, Ye Cheng, Huiru Zhang, Xing Jin, Hanxing Sun, Yue Wang, Jiqi Yan   +6 more
doaj   +1 more source

Disulfidptosis in tumor progression

Cell Death Discovery
Abstract Disulfidptosis, a regulated cell death modality driven by the cystine transporter solute carrier family 7 member 11 (SLC7A11), is characterized by actin cytoskeleton collapse under glucose starvation. This review systematically elucidates the pivotal role of disulfidptosis in tumor metabolic reprogramming, with a focus on its ...
Senlin Wan, Changming Liang, Chengwei Wu, Song Wang, Jiawei Wang, Lishuai Xu, Xu Zhang, Yinfen Hou, Yabin Xia, Li Xu, Xiaoxu Huang   +10 more
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Mechanistic Role of Disulfidptosis in Type 2 Diabetes Mellitus. [PDF]

Mol Nutr Food Res
ABSTRACT Disulfidptosis is a newly identified form of regulated cell death. It occurs under glucose‐starvation conditions and is characterized by metabolic dysregulation in cells with high expression of SLC7A11. Increased cystine uptake under these conditions leads to depletion of NADPH, ultimately triggering cell death.
Zou D, Zou Y, Jin Y, Liu S, Lin M, Deng R, Nan Z.   +6 more
europepmc   +3 more sources