Results 21 to 30 of about 2,022 (185)
Discover OncologyOvarian cancer (OC) is the most fatal, gynecological malignancy. Compared with advanced ovarian cancer, the 5 year survival rate of early ovarian cancer is significantly improved, and predicting early detection and diagnosis is very important to improve ...
Ruanruan Yang +5 more
doaj +2 more sources
PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity. [PDF]
Adv Sci (Weinh)ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Chen Y +7 more
europepmc +2 more sources
Hepatic Medicine: Evidence and Research, 2023 Qian Wei,1,2,* Yu-Chao Hou,3,* Fei-Fei Mao,4,* Jin-Kai Feng,2 Xu Wang,3 Shu-Qun Cheng1,2,* 1The First Clinical Medicine School, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 2Department of Hepatic Surgery VI,
Wei Q +5 more
doaj +1 more source
Mechanistic Role of Disulfidptosis in Type 2 Diabetes Mellitus
Molecular Nutrition & Food ResearchABSTRACT Disulfidptosis is a newly identified form of regulated cell death. It occurs under glucose‐starvation conditions and is characterized by metabolic dysregulation in cells with high expression of SLC7A11. Increased cystine uptake under these conditions leads to depletion of NADPH, ultimately triggering cell death.
Zou, Danqi +6 more
openaire +3 more sources
HeliyonBackground: Disulfidptosis is a newly discovered type of cell death. We aim to identify hub genes associated with both disulfidptosis and immune infiltration in hepatocellular carcinoma (HCC) patients, and to develop an individualized risk prediction ...
Zhe Xu, Chong Pang, Xundi Xu
doaj +2 more sources
Discover OncologyDisulfidptosis is a newfound programmed cell death (PCD) mode characterized by disulfide stress. Nevertheless, the characteristics and functional significance of disulfidptosis-related genes in head and neck squamous cell carcinoma (HNSCC) are still ...
Haiqian Zhu +5 more
doaj +2 more sources
Targeting Disulfidptosis with Potentially Bioactive Natural Products in Metabolic Cancer Therapy
MetabolitesBackground: Metabolic cancers are defined by metabolic reprogramming. Although this reprograming drives rapid tumour growth and invasion, it also reveals specific metabolic vulnerabilities that can be therapeutically exploited in cancer therapy.
Xinyan Li +6 more
doaj +2 more sources
The emerging role of disulfidptosis in metabolic synergistic death and cancer immunotherapy [PDF]
OncogenesisDisulfidptosis is an emerging form of regulated cell death (RCD) that is mechanistically distinct from, yet closely interconnected with, classical cell death modalities such as apoptosis, ferroptosis, and cuproptosis.
Zheng Wu +10 more
doaj +2 more sources
The disulfidptosis-related signature predicts prognosis and immune features in glioma patients
Scientific Reports, 2023 Glioma is the most common primary malignant tumor in the central nervous system. Disulfidptosis is a recently identified programmed cell death in tumor cells overexpressing SLC7A11 under glucose starvation.
Xiong Wang +3 more
doaj +2 more sources
HeliyonObjective: Ulcerative Colitis (UC) manifests as a chronic inflammatory condition of the intestines, marked by ongoing immune system dysregulation. Disulfidptosis, a newly identified cell death mechanism, is intimately linked to the onset and advancement ...
Lichao Yang, Lianwen Yuan, Ganglei Liu
doaj +2 more sources