Results 11 to 20 of about 1,487 (157)

Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility [PDF]

Advanced Science
Disulfidptosis, a newly identified form of programmed cell death, has emerged as a promising therapeutic target for tumors. However, the current research in this field is hindered by the absence of precise and quantifiable biomarkers to accurately ...
Congcong Zhang, Xiangdi Zhang, Shushen Li, Yuyang Li, Bei Yuan, Mingshuang Zheng, Shuo Zhang, Fangping Yuan, Min Jia, Lixia Lu, Jun Zhou, Zhenguo Zhang, Xin Du   +12 more
doaj   +3 more sources

Disulfidptosis: a new target for metabolic cancer therapy

Journal of Experimental & Clinical Cancer Research, 2023
Altered metabolism is a hallmark of cancer and presents a vulnerability that can be exploited in cancer treatment. Regulated cell death (RCD) plays a crucial role in cancer metabolic therapy.
Peijie Zheng, Chuntao Zhou, Yuemin Ding, Shiwei Duan   +3 more
doaj   +4 more sources

Pan-cancer landscape of disulfidptosis across human tumors

Heliyon
Objective: Disulfidptosis is a newly discovered disulfide stress-induced cell death form. Clinical significance and biological mechanisms of disulfidptosis in human cancers need to be further elucidated.
Kun Fang, Suxiao Jiang, Zhengjie Xu, Meng Luo, Changsheng Yan   +4 more
doaj   +3 more sources

Identification and molecular typing of disulfidptosis-related biomarkers in anaplastic thyroid carcinoma [PDF]

Cell Death Discovery
Increasing evidence suggests that disulfidptosis plays a crucial role in tumorigenesis and progression. This study aimed to identify biomarkers closely associated with disulfidptosis in anaplastic thyroid carcinoma (ATC).
Weidong Teng, Yawen Guo, Lingling Ding, Aoni Zhou, Yehao Guo, Jiantong He, Lirong zhang, Haolan Yu, Zekai Tao, Jiafeng Wang, Jiajie Xu, Zhuo Tan, Liehao Jiang   +12 more
doaj   +2 more sources

Inducing disulfidptosis in tumors:potential pathways and significance

MedComm
Regulated cell death (RCD) is crucial for the elimination of abnormal cells. In recent years, strategies aimed at inducing RCD, particularly apoptosis, have become increasingly important in cancer therapy.
Tao Mi, Xiangpan Kong, Meiling Chen, Peng Guo, Dawei He   +4 more
doaj   +3 more sources

Disulfidptosis as a key regulator of glioblastoma progression and immune cell impairment

Frontiers in Immunology
BackgroundGlioblastoma, associated with poor prognosis and impaired immune function, shows potential interactions between newly identified disulfidptosis mechanisms and T cell exhaustion, yet these remain understudied.MethodsKey genes were identified ...
Yifu Shu, Jing Li
exaly   +3 more sources

Disulfidptosis-Induced Chondrocyte-Macrophage Crosstalk via GYS1/CCND1/NOD2 Axis Promotes Osteoarthritis Progression [PDF]

Journal of Inflammation Research
Qing Sun,1,* Zhihui Wei,1,* Gaohai Shao,1 Mengfan Yang,1 Xianyan Zeng,2 Xiang Hong,1 Rong Gou,3 Han Zhang,4 Yining Zhang,5 Shuheng Dong,1 Yiming Qu,1 Yujiao Liu1,5 1Department of Orthopedics, Affiliated Yongchuan Hospital of Chongqing ...
Sun Q, Wei Z, Shao G, Yang M, Zeng X, Hong X, Gou R, Zhang H, Zhang Y, Dong S, Qu Y, Liu Y   +11 more
doaj   +2 more sources

Development of the RF-GSEA Method for Identifying Disulfidptosis-Related Genes and Application in Hepatocellular Carcinoma

Current Issues in Molecular Biology, 2023
Disulfidptosis is a newly discovered cellular programmed cell death mode. Presently, a considerable number of genes related to disulfidptosis remain undiscovered, and its significance in hepatocellular carcinoma remains unrevealed.
Linghao Ni, Qian Yu, Ruijia You, Chen Chen, Bin Peng   +4 more
doaj   +1 more source

Disulfide-Bridged Ru Complex-Mediated Photo-Disulfidptosis for Colorectal Cancer Therapy. [PDF]

Adv Sci (Weinh)
In this work, a binuclear ruthenium complex, RuSSRu was developed for efficient colorectal cancer (CRC) treatment. The synergistic interaction between disulfidptosis and lysosomal damage‐induced apoptosis induced by RuSSRu amplified tumor cell death. This innovative approach offers a potent therapeutic strategy for CRC.
He S, Jin W, Pang J, Gong X, Cao S, Mao D, Chen Y, Wang KN, Liu B.   +8 more
europepmc   +2 more sources

The Mechanism and Regulation of Disulfidptosis and Its Role in Disease. [PDF]

Biomedicines
Disulfidptosis is a recently identified form of regulatory cell death (RCD), Which has emerged as a research hotspot due to its distinctive feature of accumulating protein disulfide bonds, setting it apart from other RCD mechanisms. This discovery may offer new therapeutic strategies for cancer and various chronic diseases.
Wan Y, Jing M, Zhang L, Song Q, Ye X, Zhou Z, Yan W, Fu Y.   +7 more
europepmc   +3 more sources