Results 21 to 30 of about 19,150 (245)

Exploring the role of the disulfidptosis-related gene SLC7A11 in adrenocortical carcinoma: implications for prognosis, immune infiltration, and therapeutic strategies

Cancer Cell International, 2023
Background Disulfidptosis and the disulfidptosis-related gene SLC7A11 have recently attracted significant attention for their role in tumorigenesis and tumour management.
Tonghu Liu, Yilin Ren, Qixin Wang, Yu Wang, Zhiyuan Li, Weibo Sun, Dandan Fan, Yongkun Luan, Yukui Gao, Zechen Yan   +9 more
doaj   +1 more source

The N6‐methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma

Clinical and Translational Medicine, 2022
Background Solute carrier family 7 member 11 (SLC7A11) is overexpressed in multiple human tumours and functions as a transporter importing cystine for glutathione biosynthesis.
Li Liu, Jiangtu He, Guifeng Sun, Nan Huang, Zhixuan Bian, Chang Xu, Yue Zhang, Zhongqi Cui, Wenqiang Xu, Fenyong Sun, Chengle Zhuang, Qiuhong Man, Song Gu   +12 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed

Journal of Comparative Neurology, 2015
ABSTRACTThe cystine/glutamate antiporter or system exchanges cystine for glutamate, thereby supporting intracellular glutathione synthesis and nonvesicular glutamate release. The role of system in neurological disorders can be dual and remains a matter of debate. One important reason for the contradictory findings that have been reported to date is
Van Liefferinge, Joeri, Bentea, Eduard, Demuyser, Thomas, Albertini, Giulia, Follin-Arbelet, Virginie, Holmseth, Silvia, Merckx, Ellen, Hideyo, Sato, Aerts, Joeri L, Smolders, Ilse, Arckens, Lutgarde, Danbolt, Niels C, Massie, Ann   +12 more
openaire   +3 more sources

SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production

Frontiers in Cell and Developmental Biology, 2021
In age-related macular degeneration (AMD), one of the principal sources of vascular endothelial growth factor (VEGF) is retinal pigment epithelium (RPE) cells under hypoxia or oxidative stress. Solute carrier family 7 member 11 (SLC7A11), a key component
Xiaohuan Zhao, Xiaohuan Zhao, Xiaohuan Zhao, Xiaohuan Zhao, Min Gao, Min Gao, Min Gao, Min Gao, Jian Liang, Jian Liang, Jian Liang, Jian Liang, Yuhong Chen, Yuhong Chen, Yuhong Chen, Yuhong Chen, Yimin Wang, Yimin Wang, Yimin Wang, Yimin Wang, Yuwei Wang, Yuwei Wang, Yuwei Wang, Yuwei Wang, Yushu Xiao, Yushu Xiao, Yushu Xiao, Yushu Xiao, Zhenzhen Zhao, Zhenzhen Zhao, Zhenzhen Zhao, Zhenzhen Zhao, Xiaoling Wan, Xiaoling Wan, Xiaoling Wan, Xiaoling Wan, Mei Jiang, Mei Jiang, Mei Jiang, Mei Jiang, Xueting Luo, Xueting Luo, Xueting Luo, Xueting Luo, Feng Wang, Xiaodong Sun, Xiaodong Sun, Xiaodong Sun, Xiaodong Sun   +48 more
doaj   +1 more source

High SLC7A11 expression in normal skin of melanoma patients [PDF]

Cancer Epidemiology, 2019
Melanoma is one of the highest metastatic cancers and its incidence is rapidly increasing. A great effort has been devoted to determine gene mutations and expression profiles in melanoma cells, but less attention has been given to the possible influence of melanin synthesis in melanocytes on melanomagenesis.
Galván, Ismael, Inácio, Ângela, Dañino, María, Corbí-Llopis, Rosa, Monserrat, María T., Bernabeu-Wittel, José   +5 more
openaire   +5 more sources

Circ_0000140 Alters miR-527/SLC7A11-Mediated Ferroptosis to Influence Oral Squamous Cell Carcinoma Cell Resistance to DDP

Pharmacogenomics and Personalized Medicine, 2023
Yu Ma, Jinbo Gao, Hongning Guo Department of Stomatology, Tianjin Third Central Hospital, Tianjin, People’s Republic of ChinaCorrespondence: Yu Ma, Department of Stomatology, Tianjin Third Central Hospital, No.
Ma Y, Gao J, Guo H
doaj  

The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi‐omics study

Cancer Medicine, 2021
Background The ferroptosis inhibitory gene Solute carrier family 7 member 11 (SLC7A11) provides a new strategy for anticancer treatment. However, its function in renal cell carcinoma (RCC) remains elusive.
Fangshi Xu, Yibing Guan, Li Xue, Peng Zhang, Mingrui Li, Mei Gao, Tie Chong   +6 more
doaj   +1 more source

miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes

Journal of Inflammation Research, 2023
Yongquan Chen, Yecheng Deng, Linghua Chen, Ziyao Huang, Yi Yan, Zhaoqi Huang Department of Cardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaoqi Huang, Department of ...
Chen Y, Deng Y, Chen L, Huang Z, Yan Y, Huang Z   +5 more
doaj  

Identification of SLC7A11‐AS1/SLC7A11 pair as a ferroptosis‐related therapeutic target for hepatocellular carcinoma

Journal of Cellular and Molecular Medicine
AbstractHepatocellular carcinoma (HCC), a prevalent malignancy worldwide, poses significant challenges in terms of prognosis, necessitating innovative therapeutic approaches. Ferroptosis offers notable advantages over apoptosis, holding promise as a novel therapeutic approach for HCC complexities. Moreover, while the interaction between long non‐coding
Xiao Yuan, Yida Wang, Sitong Jiao, Huanhuan Gao, Mengqian Zhang, Xin Wang, Xunyu Zhou, Chuanfang Wu, Jinku Bao   +8 more
openaire   +2 more sources