Results 21 to 30 of about 21,100 (250)
International Journal of General Medicine, 2022 Yi Lin,1 Yubing Dong,2 Wanyu Liu,2 Xingyun Fan,2 Ying Sun3 1Department of Anesthesiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, People’s Republic of China; 2Department of Internal Medicine, First ...
Lin Y, Dong Y, Liu W, Fan X, Sun Y
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Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission [PDF]
Advanced scienceThis study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Yu W +12 more
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BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression
Molecular & Cellular Oncology, 2019 The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive.
Yilei Zhang, Li Zhuang, Boyi Gan
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High SLC7A11 expression in normal skin of melanoma patients [PDF]
Cancer Epidemiology, 2019 Melanoma is one of the highest metastatic cancers and its incidence is rapidly increasing. A great effort has been devoted to determine gene mutations and expression profiles in melanoma cells, but less attention has been given to the possible influence of melanin synthesis in melanocytes on melanomagenesis.
Galván, Ismael +5 more
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Cancer Cell International, 2023 Background Disulfidptosis and the disulfidptosis-related gene SLC7A11 have recently attracted significant attention for their role in tumorigenesis and tumour management.
Tonghu Liu +9 more
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Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed
Journal of Comparative Neurology, 2015 ABSTRACTThe cystine/glutamate antiporter or system exchanges cystine for glutamate, thereby supporting intracellular glutathione synthesis and nonvesicular glutamate release. The role of system in neurological disorders can be dual and remains a matter of debate. One important reason for the contradictory findings that have been reported to date is
Van Liefferinge, Joeri +12 more
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Frontiers in Cell and Developmental Biology, 2021 In age-related macular degeneration (AMD), one of the principal sources of vascular endothelial growth factor (VEGF) is retinal pigment epithelium (RPE) cells under hypoxia or oxidative stress. Solute carrier family 7 member 11 (SLC7A11), a key component
Xiaohuan Zhao +48 more
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Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1 [PDF]
Cell Cycle, 2019 SLC7A11 (or xCT) imports extracellular cystine into cells to promote glutathione synthesis, thus inhibiting ferroptosis. SLC7A11 expression is tightly controlled in normal cells and its dysregulation results in aberrant expression of SLC7A11 in human cancers.
Yilei Zhang, Pranavi Koppula, Boyi Gan
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Pharmacogenomics and Personalized Medicine, 2023 Yu Ma, Jinbo Gao, Hongning Guo Department of Stomatology, Tianjin Third Central Hospital, Tianjin, People’s Republic of ChinaCorrespondence: Yu Ma, Department of Stomatology, Tianjin Third Central Hospital, No.
Ma Y, Gao J, Guo H
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The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 [PDF]
Cancer Research, 2019 Abstract Although cell-cycle arrest, senescence, and apoptosis are established mechanisms of tumor suppression, accumulating evidence reveals that ferroptosis, an iron-dependent, nonapoptotic form of cell death, represents a new regulatory pathway in suppressing tumor development.
Tong, Liu +3 more
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