Results 21 to 30 of about 20,364 (275)

Mex-3 RNA-binding family member A limits macrophage ferroptosis-associated injury linked to the SLC7A11/GPX4 pathway in diabetic atherosclerosis. [PDF]

Clin Transl Med
Diabetes reduces macrophage MEX3A and aggravates atherosclerotic plaque instability. MEX3A stabilises Slc7a11 and Gpx4 mRNAs to sustain SLC7A11/GPX4 antioxidant defence. MEX3A deficiency promotes macrophage ferroptosis, lipid peroxidation and mitochondrial injury. Ferrostatin‐1 partially attenuates ferroptotic injury and diabetic plaque destabilisation.
Ma Y, Liu J, Xing Y, Pan S, Annayev BH, Wu W, Wang X, Liu Z.   +7 more
europepmc   +2 more sources

An integrated analysis of SLC7A11 as a pan-cancer immunotherapeutic biomarker with experimental validation of its regulation by miR-148b-3p in breast cancer [PDF]

Frontiers in Immunology
BackgroundIdentifying reliable biomarkers for immunotherapy response remains challenging. Solute carrier family 7 member 11 (SLC7A11), a key regulator of redox homeostasis and ferroptosis, demonstrates significant tumor-promoting potential across cancers,
Songchen Zhao, Miao Zheng, Guannan Ma, Kaifeng Niu, Kaifeng Niu, Lei Zhang, Lei Zhang   +6 more
doaj   +2 more sources

CIRBP Stabilizes Slc7a11 mRNA to Sustain the SLC7A11/GPX4 Antioxidant Axis and Limit Ferroptosis in Doxorubicin-Induced Cardiotoxicity

Antioxidants
Doxorubicin-induced cardiotoxicity (DIC) significantly constrains the clinical efficacy of anthracycline chemotherapy, primarily through the induction of ferroptosis, an iron-dependent, regulated cell death driven by oxidative stress and lipid peroxidation. However, the upstream regulators of ferroptosis in DIC remain incompletely defined.
Yixin Xie, Yongnan Li, Yafei Xie, Jianshu Chen, Hong Ding, Xiaowei Zhang   +5 more
openaire   +3 more sources

Rotavirus-induced lncRNA SLC7A11-AS1 promotes ferroptosis by targeting cystine/glutamate antiporter xCT (SLC7A11) to facilitate virus infection

Virus Research
Rotavirus (RV) is the primary etiological agent of virus-associated gastroenteritis in infants, causing 200,000 childhood death annually. Despite the availability of vaccines, rotaviral diarrhea continues to be a severe issue in underdeveloped nations in Asia and Africa.
Shreya Banerjee, Rakesh Sarkar, Arpita Mukherjee, Suvrotoa Mitra, Animesh Gope, Mamta Chawla-Sarkar   +5 more
openaire   +4 more sources

SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression

Redox Biology
The changes of inflammation and metabolism are two features in nonalcoholic steatohepatitis (NASH). However, how they interact to regulate NASH progression remains largely unknown.
Tingting Lv, Xiude Fan, Chang He
exaly   +3 more sources

The High Expression of SLC7A11 and GPX4 are Significantly Correlated with β-Catenin in Colorectal Cancer

Cancer Management and Research
Yurong Ou, Ningqi Wu, Lishan Shu, Yang Zhao, Yunfang Bao, Qiong Wu Department of Pathology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, People’s Republic of ChinaCorrespondence: Qiong Wu, Department of Pathology, The First ...
Ou Y, Wu N, Shu L, Zhao Y, Bao Y, Wu Q
doaj   +2 more sources

High glucose induces podocyte ferroptosis through BAP1/SLC7A11 pathway

Heliyon
Background: Ferroptosis plays an important role in the development of diabetic nephropathy (DN). However, its specific regulatory mechanisms remain unclear.
Ren Peiyao, Man Xueli, Sun Wenbo, Zheng Danna, Gong Jianguang, Jin Juan, He Qiang   +6 more
doaj   +2 more sources

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio
The cystine/glutamate antiporter, solute carrier family 7 member 11 (SLC7A11), plays a crucial role in regulating redox homeostasis and cell death processes such as apoptosis and ferroptosis.
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
doaj   +2 more sources

Blocking SLC7A11 attenuates the proliferation of esophageal squamous cell carcinoma cells

Animal Cells and Systems
The role of ferroptosis-associated gene SLC7A11 in esophageal cancer progression is largely unknown, therefore, the effects of blocking SLC7A11 on esophageal squamous cell carcinoma (ESCC) cells are evaluated.
Wen-Ting Li, Xin Jin, Sheng-Jie Song, Chong Wang, Chuang Fu, Wen Jiang, Jie Bai, Zhi-Zhou Shi   +7 more
doaj   +2 more sources

Network Pharmacology and Integrated Experimental Evidence Demonstrate That Ophiopogonin D Suppresses Hepatocellular Carcinoma Progression via the UCK2-SLC7A11 Axis. [PDF]

Food Sci Nutr
Ophiopogonin D exerts anti‐HCC effects by targeting UCK2 and inducing ferroptosis via the UCK2‐SLC7A11 axis. ABSTRACT Hepatocellular carcinoma (HCC) treatment faces significant challenges, including high toxicity and drug resistance. Ophiopogonin D, the active compound derived from the medicinal food material Ophiopogon japonicus (Mai Dong), has ...
Hao Y, Muhammad H, Wang Y, Wang Y, Cui L, Quan J, Xie B, Li X.   +7 more
europepmc   +2 more sources