Results 11 to 20 of about 21,100 (250)

SLC7A11, a potential immunotherapeutic target in lung adenocarcinoma

Scientific Reports, 2023
SLC7A11 has significant translational value in cancer treatment. However, there are few studies on whether SLC7A11 affects the immune status of lung adenocarcinoma (LUAD).
Qingqing Shan, Chi Zhang, Yangke Li, Qunying Li, Yifan Zhang, Xue Li, Junqing Shi, Fengying Hu   +7 more
doaj   +3 more sources

The amino acid transporter SLC7A11 expression in breast cancer

Cancer Biology & Therapy, 2023
Breast cancer (BC), characterized by its diverse molecular profiles and clinical outcomes, presents a significant challenge in the development of effective therapeutic strategies.
Preyanka Nath, Lutfi H. Alfarsi, Rokaya El-Ansari, Brendah K. Masisi, Busra Erkan, Ali Fakroun, Ian O. Ellis, Emad A. Rakha, Andrew R. Green   +8 more
doaj   +3 more sources

Helicobacter pylori-Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis. [PDF]

Adv Sci (Weinh)
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Ning J, Guan X, Hao X, Zhang J, Li D, Xiong Y, Zhang W, Han X, Lang Y, Zhou M, Yang M, Huang Z, Qu T, Zu M, Meng Q, Fu W, Lu F, Zhang J, Chen X, Liu T, Ding S.   +20 more
europepmc   +2 more sources

Glioma, glutamate (SLC7A11) and seizures—a commentary [PDF]

Annals of Translational Medicine, 2017
Glioma, a common type of adult primary brain tumor and also the most dreaded, often presents to the clinic with seizures. These seizures are usually difficult to control with the standard anti-epileptics. Some of the patients presenting with medically refractory epilepsy due to a low grade glioma, achieve seizure control by surgical resection but some ...
Vani, Santosh, Palavalasa, Sravya
openaire   +2 more sources

Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

Molecular Cell, 2022
IDO1 oxidizes tryptophan (TRP) to generate kynurenine (KYN), the substrate for 1-carbon and NAD metabolism, and is implicated in pro-cancer pathophysiology and infection biology. However, the mechanistic relationships between IDO1 in amino acid depletion versus product generation have remained a longstanding mystery.
Alessandra Fiore, Leonie Zeitler, Marion Russier, Annette Groß, Maria-Kathrin Hiller, Joanne L. Parker, Luca Stier, Thomas Köcher, Simon Newstead, Peter J. Murray   +9 more
openaire   +3 more sources

Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma

BMC Molecular and Cell Biology, 2022
Background Chaperonin containing TCP1 subunit 3 (CCT3) acts as an oncogene in cancers, whereas its role and underlying mechanisms in lung adenocarcinoma (LUAD) are poorly understood.
Kun Wang, Jian He, Changling Tu, Hui Xu, Xugang Zhang, Yongchang Lv, Chao Song   +6 more
doaj   +1 more source

Metformin Induces Ferroptosis byInhibiting UFMylation of SLC7A11 in Breast Cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2021
Abstract Background Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxidation and is involved in various pathophysiological conditions, including cancer. Targeting ferroptosis is considered to be a novel anti-cancer strategy.
Jingjing Yang, Yulu Zhou, Shuduo Xie, Ji Wang, Zhaoqing Li, Lini Chen, Misha Mao, Cong Chen, Aihua Huang, Yongxia Chen, Xun Zhang, Noor Ul Hassan Khan, Linbo Wang, Jichun Zhou   +13 more
openaire   +3 more sources

Ferroptosis-associated gene SLC7A11 is upregulated in NSCLC and correlated with patient’s poor prognosis: An integrated bioinformatics analysis

Pteridines, 2021
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, which was involved in the progression of malignant tumors including non-small cell lung cancer (NSCLC).
Huang He, Liu Juan, Wu Haiyan, Liu Fang, Zhou Xiaoxi   +4 more
doaj   +1 more source

A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis

Molecular & Cellular Oncology, 2021
Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
doaj   +1 more source

Inhibiting system xC− and glutathione biosynthesis – a potential Achilles' heel in mutant-p53 cancers

Molecular & Cellular Oncology, 2017
Effective therapeutic strategies to target mutant tumor protein p53 (TP53, best known as p53) cancers remain an unmet medical need. We found that mutant p53 impairs the function of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2, commonly known as ...
Nicholas J. Clemons, David S. Liu, Cuong P. Duong, Wayne A. Phillips   +3 more
doaj   +1 more source