Results 11 to 20 of about 23,034 (273)

SLC7A11, a potential immunotherapeutic target in lung adenocarcinoma

Scientific Reports, 2023
SLC7A11 has significant translational value in cancer treatment. However, there are few studies on whether SLC7A11 affects the immune status of lung adenocarcinoma (LUAD).
Qingqing Shan, Chi Zhang, Yangke Li, Qunying Li, Yifan Zhang, Xue Li, Junqing Shi, Fengying Hu   +7 more
doaj   +3 more sources

The amino acid transporter SLC7A11 expression in breast cancer

Cancer Biology & Therapy, 2023
Breast cancer (BC), characterized by its diverse molecular profiles and clinical outcomes, presents a significant challenge in the development of effective therapeutic strategies.
Preyanka Nath, Lutfi H. Alfarsi, Rokaya El-Ansari, Brendah K. Masisi, Busra Erkan, Ali Fakroun, Ian O. Ellis, Emad A. Rakha, Andrew R. Green   +8 more
doaj   +3 more sources

Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis

Genes and Diseases
Although cell-cycle arrest, senescence, and apoptosis are well accepted as the classic barriers in tumorigenesis, recent studies indicate that metabolic regulation is equally important as a major checkpoint in cancer development. It is well accepted that
Zhenyi Su, Yanqing Liu, Lin Wang, Wei Gu
doaj   +3 more sources

Glioma, glutamate (SLC7A11) and seizures—a commentary [PDF]

Annals of Translational Medicine, 2017
Glioma, a common type of adult primary brain tumor and also the most dreaded, often presents to the clinic with seizures. These seizures are usually difficult to control with the standard anti-epileptics. Some of the patients presenting with medically refractory epilepsy due to a low grade glioma, achieve seizure control by surgical resection but some ...
Vani, Santosh, Palavalasa, Sravya
openaire   +2 more sources

Change of cystine/glutamate antiporter expression in ethanol-dependent rats [PDF]

, 2014
Background: Some drugs of abuse down regulate the expression of cystine/glutamate (xCT) antiporter in the nucleus accumbens (Acb) after extinction or withdrawal.
Alessandra T. Peana, Federico Bennardini, Giulia Muggironi   +2 more
core   +6 more sources

Transcriptional Profiles for Glutamate Transporters Reveal Differences Between Organophosphates but Similarities with Unrelated Neurotoxicants [PDF]

, 2010
The developmental neurotoxicity of organophosphates involves mechanisms other than their shared property as cholinesterase inhibitors, among which are excitotoxicity and oxidative stress.
Lobner, Doug, Seidler, Frederic J., Slotkin, Theodore A.   +2 more
core   +2 more sources

Reduced Expression of miRNA-27a Modulates Cisplatin Resistance in Bladder Cancer by Targeting the Cystine/Glutamate Exchanger SLC7A11 [PDF]

, 2014
Purpose: Resistance to cisplatin-based chemotherapy is a major obstacle to bladder cancer treatment. We aimed to identify microRNAs (miRNA) that are dysregulated in cisplatin-resistant disease, ascertain how these contribute to a drug-resistant phenotype,
Bertz, S., Bryant, H.E., Catto, J.W.F., Drayton, R.M., Dudziec, E., Hartmann, A., Peter, S.   +6 more
core   +2 more sources

Metformin Induces Ferroptosis byInhibiting UFMylation of SLC7A11 in Breast Cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2021
Abstract Background Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxidation and is involved in various pathophysiological conditions, including cancer. Targeting ferroptosis is considered to be a novel anti-cancer strategy.
Jingjing Yang, Yulu Zhou, Shuduo Xie, Ji Wang, Zhaoqing Li, Lini Chen, Misha Mao, Cong Chen, Aihua Huang, Yongxia Chen, Xun Zhang, Noor Ul Hassan Khan, Linbo Wang, Jichun Zhou   +13 more
openaire   +3 more sources

Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma

BMC Molecular and Cell Biology, 2022
Background Chaperonin containing TCP1 subunit 3 (CCT3) acts as an oncogene in cancers, whereas its role and underlying mechanisms in lung adenocarcinoma (LUAD) are poorly understood.
Kun Wang, Jian He, Changling Tu, Hui Xu, Xugang Zhang, Yongchang Lv, Chao Song   +6 more
doaj   +1 more source

Ferroptosis-associated gene SLC7A11 is upregulated in NSCLC and correlated with patient’s poor prognosis: An integrated bioinformatics analysis

Pteridines, 2021
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, which was involved in the progression of malignant tumors including non-small cell lung cancer (NSCLC).
Huang He, Liu Juan, Wu Haiyan, Liu Fang, Zhou Xiaoxi   +4 more
doaj   +1 more source