Results 11 to 20 of about 19,150 (245)
SLC7A11, a potential immunotherapeutic target in lung adenocarcinoma
Scientific Reports, 2023 SLC7A11 has significant translational value in cancer treatment. However, there are few studies on whether SLC7A11 affects the immune status of lung adenocarcinoma (LUAD).
Qingqing Shan +7 more
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The amino acid transporter SLC7A11 expression in breast cancer
Cancer Biology & Therapy, 2023 Breast cancer (BC), characterized by its diverse molecular profiles and clinical outcomes, presents a significant challenge in the development of effective therapeutic strategies.
Preyanka Nath +8 more
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Glioma, glutamate (SLC7A11) and seizures—a commentary [PDF]
Annals of Translational Medicine, 2017 Glioma, a common type of adult primary brain tumor and also the most dreaded, often presents to the clinic with seizures. These seizures are usually difficult to control with the standard anti-epileptics. Some of the patients presenting with medically refractory epilepsy due to a low grade glioma, achieve seizure control by surgical resection but some ...
Vani, Santosh, Palavalasa, Sravya
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Slc7a11 modulated by POU2F1 is involved in pigmentation in rabbit [PDF]
International Journal of Molecular Sciences, 2019 Abstract Solute carrier family 7 member 11 (Slc7a11) codes for a cystine/glutamate xCT transporter and can control production of pheomelanin pigment to change fur and skin colors of animals. Previous studies found that the skin expression levels of Slc7a11 varied significantly with the fur colors of the Rex Rabbit.
Chen, Yang +8 more
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Metformin Induces Ferroptosis byInhibiting UFMylation of SLC7A11 in Breast Cancer [PDF]
Journal of Experimental & Clinical Cancer Research, 2021 Abstract Background Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxidation and is involved in various pathophysiological conditions, including cancer. Targeting ferroptosis is considered to be a novel anti-cancer strategy.
Jingjing Yang +13 more
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A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis
Molecular & Cellular Oncology, 2021 Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
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International Journal of General Medicine, 2022 Yi Lin,1 Yubing Dong,2 Wanyu Liu,2 Xingyun Fan,2 Ying Sun3 1Department of Anesthesiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, People’s Republic of China; 2Department of Internal Medicine, First ...
Lin Y, Dong Y, Liu W, Fan X, Sun Y
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SLC7A11, a Potential Therapeutic Target Through Induced Ferroptosis in Colon Adenocarcinoma
Frontiers in Molecular Biosciences, 2022 Background: Ferroptosis induced by SLC7A11 has an important translational value in the treatment of cancers. However, the mechanism of SLC7A11 in the pathogenesis of colon adenocarcinoma (COAD) is rarely studied in detail.Methods: SLC7A11 expression was ...
Xin Cheng +5 more
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The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer [PDF]
Frontiers in Oncology, 2022 SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione synthesis; a process that protects cells from oxidative stress and is, therefore, critical to cell growth, proliferation, and metabolism.
Nidhi Jyotsana +5 more
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BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression
Molecular & Cellular Oncology, 2019 The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive.
Yilei Zhang, Li Zhuang, Boyi Gan
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