Results 11 to 20 of about 20,364 (275)
Role of SLC7A11/xCT in Ovarian Cancer [PDF]
International Journal of Molecular SciencesOvarian cancer is one of the most dangerous gynecologic cancers worldwide and has a high fatality rate due to diagnosis at an advanced stage of the disease as well as a high recurrence rate due to the occurrence of chemotherapy resistance. In fact, chemoresistance weakens the therapeutic effects, worsening the outcome of this pathology.
Sonia Fantone +2 more
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Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis
Genes and DiseasesAlthough cell-cycle arrest, senescence, and apoptosis are well accepted as the classic barriers in tumorigenesis, recent studies indicate that metabolic regulation is equally important as a major checkpoint in cancer development. It is well accepted that
Zhenyi Su, Yanqing Liu, Lin Wang, Wei Gu
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Journal of Inflammation Research, 2023 Yongquan Chen, Yecheng Deng, Linghua Chen, Ziyao Huang, Yi Yan, Zhaoqi Huang Department of Cardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaoqi Huang, Department of ...
Chen Y +5 more
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Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1 [PDF]
Cell Cycle, 2019 SLC7A11 (or xCT) imports extracellular cystine into cells to promote glutathione synthesis, thus inhibiting ferroptosis. SLC7A11 expression is tightly controlled in normal cells and its dysregulation results in aberrant expression of SLC7A11 in human cancers.
Yilei Zhang, Pranavi Koppula, Boyi Gan
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Differential expression of SLC7A11 in colorectal cancer.
, 2023 Cancer is a leading cause of death and colorectal cancer is among the most lethal cancers (1, 2). We mined published microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with colorectal cancer (CRC). We found significant differential
Shahan Mamoor
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BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression
Molecular & Cellular Oncology, 2019 The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive.
Yilei Zhang, Li Zhuang, Boyi Gan
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Cancer Cell International, 2023 Background Disulfidptosis and the disulfidptosis-related gene SLC7A11 have recently attracted significant attention for their role in tumorigenesis and tumour management.
Tonghu Liu +9 more
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Clinical and Translational Medicine, 2022 Background Solute carrier family 7 member 11 (SLC7A11) is overexpressed in multiple human tumours and functions as a transporter importing cystine for glutathione biosynthesis.
Nan Huang, Zhixuan Bian, Yue Zhang
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SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells
Nature Communications, 2023 The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT) protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we report a surprising finding that, whereas moderate overexpression of SLC7A11 is
Yuelong Yan +14 more
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SLC7A11: the Achilles heel of tumor?
Frontiers in ImmunologyThe non-natriuretic-dependent glutamate/cystine inverse transporter-system Xc- is composed of two protein subunits, SLC7A11 and SLC3A2, with SLC7A11 serving as the primary functional component responsible for cystine uptake and glutathione biosynthesis.
Yulang Jiang +2 more
exaly +4 more sources