Results 91 to 100 of about 260,155 (239)
FEBS Open Bio, EarlyView.SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel +13 more
wiley +1 more source
The USP18 cysteine protease promotes HBV production independent of its protease activity
Virology Journal, 2020 Background Hepatitis B virus (HBV) infection remains as one of the major public health problems in the world. Type I interferon (IFN) plays an essential role in antiviral defense by induced expression of a few hundred interferon stimulated genes (ISGs ...
Yujia Li +7 more
doaj +1 more source
Clinical and Translational Allergy, 2023 Background Astigmatic mites contain potent allergens that can trigger IgE‐mediated immune responses, leading to allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.
Ling Shi +9 more
doaj +1 more source
Identification of three stage-specific proteinases of Plasmodium falciparum. [PDF]
, 1987 We have identified and characterized three stage-specific proteinases of Plasmodium falciparum that are active at neutral pH. We analyzed ring-, trophozoite-, schizont-, and merozoite-stage parasites by gelatin substrate PAGE and characterized the ...
Kim, K +3 more
core +2 more sources
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Proteomes, 2017 Oilseed rape is characterized by a low nitrogen remobilization efficiency during leaf senescence, mainly due to a lack of proteolysis. Because cotyledons are subjected to senescence, it was hypothesized that contrasting protease activities between ...
Marine Poret +5 more
doaj +1 more source
The Structural Biology and Critical Evaluation of Bacterial Proteases as Targets in New Drug Design [PDF]
arXiv, 2014 Bacteria produce a range of proteolytic enzymes, for which a number human equivalent or structurally similar examples exist and the primary focus of this study was to analyse the published literature to find proteolytic enzymes, specifically endoproteses and to examine the similarity in the substrates that they act on so as to predict a suitable ...
arxiv
THz spectroscopy on amino acids [PDF]
J. Chem. Phys. 160 (2024) 145103, 2023 We present a detailed study on the temperature-dependent THz spectra of the polycrystalline amino acids L-serine and L-cysteine for wave numbers from 20 to 120 cm-1 and temperatures from 4 to 300 K. Even though the structure of these two amino acids is very similar, with a sulfur atom in the side chain of cysteine instead of an oxygen atom in serine ...
arxiv
The purification and characterisation of novel dipeptidyl peptidase IV-like activity from bovine serum [PDF]
, 2004 The discovery of a potentially novel proline-specific peptidase from bovine serum is presented which is capable of cleaving the dipeptidyl peptidase IV (DPIV) substrate Gly-Pro-MCA.
Abbott +31 more
core +1 more source
Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis
Advanced Biology, EarlyView.Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard +7 more
wiley +1 more source