Results 111 to 120 of about 260,155 (239)
Advanced Functional Materials, EarlyView.Synthetic cells are engineered herein to respond to an external chemical messenger by the activation of intracellular catalysis. The chemical messenger molecules are catalytically generated by an extracellular enzyme or a mineral surface, whereas the intracellular catalysis emerges via direct enzyme activation or via protein refolding.
Dante G. Andersen +5 more
wiley +1 more source
Expression and processing of the Hepatitis E virus ORF1 nonstructural polyprotein
Virology Journal, 2006 Background The ORF1 of hepatitis E virus (HEV) encodes a nonstructural polyprotein of ~186 kDa that has putative domains for four enzymes: a methyltransferase, a papain-like cysteine protease, a RNA helicase and a RNA dependent RNA polymerase.
Chakraborty Mahua +3 more
doaj +1 more source
Role of glutathionylation in infection and inflammation [PDF]
, 2019 Glutathionylation, that is, the formation of mixed disulfides between protein cysteines and glutathione (GSH) cysteines, is a reversible post-translational modification catalyzed by dierent cellular oxidoreductases, by which the redox state of the cell
Baldelli, S. +5 more
core +1 more source
Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction
Advanced Materials, EarlyView.We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin +17 more
wiley +1 more source
Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules
Advanced Materials Interfaces, EarlyView.This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania +2 more
wiley +1 more source
Serpins : form, function and dysfunction [PDF]
, 2013 The serpin superfamily of serine protease inhibitors is one of the most ubiquitous and successful classes of inhibitors in the living world. Their unique mechanism of suicide inhibition has led to much research and several important discoveries.
Cassar, Nicholas J., Hunter, Gary J.
core +1 more source
Advanced Materials Interfaces, EarlyView.An all aqueous synthesis of poly(ethylene glycol)‐amide‐norbornene‐carboxylate (PEGaNBCA) is developed via reacting carbic anhydride with amino‐terminated PEG. PEGaNBCA is readily crosslinked into hydrogels by click chemistries. PEGaNBCA crosslinked thiol‐norbornene hydrogels are hydrolytically stable but can be rendered hydrolytically labile through ...
Nathan H. Dimmitt, Chien‐Chi Lin
wiley +1 more source
SARS CoV subunit vaccine: Antibodymediated neutralisation and enhancement [PDF]
, 2012 1. A SARS vaccine was produced based on recombinant native full-length Spike-protein trimers (triSpike) and efficient establishment of a vaccination procedure in rodents. 2.
Altmeyer, R +14 more
core +1 more source
Advanced Science, EarlyView.Hepatoblastoma, an aggressive childhood liver tumor, origins from malignant hepatoblast‐like cells. Single‐cell analysis reveals IGF2‐driven pathways promoting malignancy. Targeting these pathways offers promising treatments, with serum IGF2 as a potential diagnostic biomarker.
Miao Ding +12 more
wiley +1 more source
Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers [PDF]
, 2003 Objectives: Our study sought to elucidate the role of oxidative stress for shedding of tumor necrosis factor-α (TNF-α) and for activating TNF-α-converting enzyme (TACE).
Becker, Bernhard F. +4 more
core +1 more source