Results 81 to 90 of about 505,883 (217)

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

Advanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin   +10 more
wiley   +1 more source

Duodenal Gastrointestinal Stromal Tumour—Mimicking a Cystic Lesion

The Surgery Journal
Although gastrointestinal stromal tumours (GISTs) mostly present as solid tumours, they may rarely manifest as cystic lesions. A 52-year-old man presented with a large globular lump in the supraumbilical region for 5 months. Triphasic CECT showed a large,
Niraj Kumar Srivastava, Somtirtha Ray, Amritanshu Saurabh, Sunita Singh, Shirish Kumar, Niraj Kumari   +5 more
doaj   +1 more source

ViTAMIn‐O: Democratizing Computer Vision‐Based Machine Learning for Stem Cell Research

Advanced Intelligent Systems, EarlyView.
This study introduces a fully open generalist computer vision model for predicting the differentiation outcomes of stem cell‐based model systems, together with its code‐free deployment platform, ColabViTAMIn‐O. It is benchmarked against various architectures, datasets, and training protocols.
Ferhat Hamurcu, Markus Breunig, Arpad Varga, Bianka Bosch, Jessica Lindenmayer, Anjan T. Kanakappady, Kevin Achberger, Natalia Pashkovskaia, Alexander Kleger, Stefan Liebau, Stefanie Klingenstein, Moritz Klingenstein   +11 more
wiley   +1 more source

When Teratoma Masquerades: A Rare Case of Intrapleural Mature Cystic Teratoma Mimicking Tuberculous Empyema

Respirology Case Reports
Teratomas are germ cell tumours generally gonadal in origin and very rare, arising from extra gonadal tissue. The most common extragonadal teratomas are mediastinal, and the majority are benign. We report a case of a 49‐year‐old lady with recurrent right
Nik Nuratiqah Nik Abeed, Ng Boon Hau, Nor Safiqah Sharil, Andrea Ban Yu Lin, Marfua'h Nik Ezzamudin, Hairulfaizi Haron   +5 more
doaj   +1 more source

Case Report: Congenital Pulmonary Airway Malformation—A Rare Cystic Lung Malformation

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Congenital pulmonary airway malformation is a rare congenital malformation of the lower respiratory tract with a worldwide incidence of 1: 11,000 to 1: 33,000 live births.
Gurpreet K. Walia, Ramanjit S. Akal, Prateek Kinra   +2 more
doaj   +1 more source

A Novel Constitutional TUBB Variant Associated With Familial Malformations of Cortical Development

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Most pathogenic tubulin variants arise de novo in sporadic patients, causing severe brain malformations and significant neurodevelopmental impairment. The resulting reproductive disadvantage typically prevents these mutations from being transmitted to offspring.
Elena Cellini, Davide Mei, Mara Cavallin, Simona Fiori, Luciana Tramacere, Maria Elena Melica, Giulia Antonelli, Simona Virdò, Elena Parrini, Renzo Guerrini   +9 more
wiley   +1 more source

L‐Cysteine and N‐Acetylcysteine Supplementation Improves Clinical Outcome in a Patient With COXPD10

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT MTO1 is a nuclear gene that encodes a mitochondrial protein essential for modifying mitochondrial transfer RNAs (tRNAs) and stabilizing codon‐anticodon interactions to ensure accurate and efficient mitochondrial protein synthesis and oxidative phosphorylation.
Nishitha R. Pillai, Sara A. Elsbecker, Grace Bronken McCarthy, Kaitlin Weisshappel, Peter Karachunski, Fernando Scaglia   +5 more
wiley   +1 more source

Management of Large Ovarian Tumors in Elderly Patients Using the Aron Alpha Method and Principles of Enhanced Recovery after Surgery

Gynecology and Minimally Invasive Therapy
Objectives: We performed preoperative evaluations of giant ovarian tumors in older adult patients using the comprehensive geriatric assessment (CGA) and estimation of physiologic ability and surgical stress (E-PASS) scoring systems.
Kaoru Kakinuma, Toshiyuki Kakinuma, Ayaka Kaneko, Nobuhiro Takeshima, Kaoru Yanagida, Michitaka Ohwada   +5 more
doaj   +1 more source

Expanding the Phenotypic Spectrum of TXNDC15‐Related Ciliopathies to Include Joubert Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic loss‐of‐function variants in TXNDC15 are a known cause of the perinatally lethal ciliopathy Meckel syndrome (MKS). TXNDC15 encodes an endoplasmic reticulum (ER)‐resident thioredoxin‐domain protein required for ciliary transition zone integrity.
Zachary T. Sentell, Robert Geraghty, Juliana E. Arcila‐Galvis, Praveen Dhondurao‐Sudhindar, Sergio Foullerat Cañada, Fulvio D'Abrusco, Bosanka Jocic‐Jakubi, Miguel Barroso‐Gil, Valentina Serpieri, Thomas M. Kitzler, Kate E. Chandler, Eleanor G. Seaby, Gabrielle Wheway, Jennifer C. Dempsey, Dan Doherty, Enza M. Valente, John A. Sayer   +16 more
wiley   +1 more source

Complications and Clinical Outcomes Following Modified Endoscopic Denker's With Pyriform Aperture Preservation: A Prospective Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The modified endoscopic Denker's (MED) approach provides access to all maxillary sinus (MS) walls for resection of various MS and retromaxillary pathologies, but the anteromedial maxilla has historically been resected. This study determined complication rates and outcomes following MED with pyriform aperture (PA) preservation ...
Yasser Almansour, Lane Donaldson, Khaled Kashlan, Swapna Vemuri, Jun Jin, John R. Craig   +5 more
wiley   +1 more source