Results 201 to 210 of about 117,699 (379)

Defining the polycystin pharmacophore through high‐throughput screening and computational biophysics

open access: yesBritish Journal of Pharmacology, EarlyView.
An unbiased high throughput electrophysiology screen identifies potent PKD2L1 channel inhibitors with divergent chemical composition that bind to pore fenestration receptors and stabilise their inactivated state. Abstract Background and Purpose Polycystins (PKD2, PKD2L1) are voltage‐gated and Ca2+‐modulated members of the TRP family of ion channels ...
Eduardo Guadarrama   +2 more
wiley   +1 more source

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan   +14 more
wiley   +1 more source

What is the accuracy of prenatal ultrasound diagnosis in fetal cystic kidney disease? [PDF]

open access: bronze, 2003
Julio Mateus   +8 more
openalex   +1 more source

Scalable Matrigel‐Free Suspension Culture for Generating High‐Quality Human Liver Ductal Organoids

open access: yesCell Proliferation, EarlyView.
A novel matrigel‐free suspension culture enhances the generation of high‐quality human liver ductal organoids, which shows remarkable efficacy in mice transplantation. ABSTRACT Liver transplantation is currently the sole definitive treatment option for end‐stage liver failure.
Senyi Gong   +14 more
wiley   +1 more source

Intelligent Manufacturing for Osteoarthritis Organoids

open access: yesCell Proliferation, EarlyView.
Overall schematic of intelligent manufacturing in osteoarthritis organoids. Broad overview of the article's structure, outlining the progression from fundamental joint anatomy and OA pathogenesis to organoid construction and, ultimately, to intelligent manufacturing and future prospects.
Xukun Lyu, Jian Wang, Jiacan Su
wiley   +1 more source

Comparison of Acquired Cystic Kidney Disease between Hemodialysis and Continuous AmbulatoryPeritoneal Dialysis

open access: gold, 2000
Jung Hee Park   +9 more
openalex   +1 more source

Type 1 diabetes presenting in adults: Trends, diagnostic challenges and unique features

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Type 1 diabetes (T1D) has been historically regarded as a childhood‐onset disease; however, recent epidemiological data indicate that adult‐onset T1D accounts for a substantial proportion of cases worldwide. There is evidence that adult‐onset T1D is associated with the classic T1D triad of elevated genetic risk, the presence of islet‐specific ...
Carmella Evans‐Molina, Richard A. Oram
wiley   +1 more source

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