Results 231 to 240 of about 621,963 (341)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Unusual familial cystic kidney disease: combining fine radiologic and genetic evaluation to solve the case. [PDF]

BMC Nephrol
Bodard S, Nabbout R, Hélénon O, Knebelmann B.   +3 more
europepmc   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy

Journal of Medical Genetics, 2002
T. Hart, M. Gorry, P. Hart, A. S. Woodard, Z. Shihabi, J. Sandhu, B. Shirts, L. Xu, H. Zhu, M. Barmada, A. Bleyer   +10 more
semanticscholar   +1 more source

Determining the Frequency of Acquired Cystic Kidney Disease in End Stage Renal Disease Patients on Hemodialysis at Dialysis Centre of Tertiary Care Hospital. [PDF]

Cureus, 2020
Aleem M, Saleem K, Zafar S, Umer A, Arshad R, Nawaz A.   +5 more
europepmc   +1 more source

Uncoupling Metastasis and Epithelial‐to‐Mesenchymal Transition in sgP19/kRAS‐Driven Spontaneous Metastatic Liver Tumor Model

Advanced Science, Volume 13, Issue 8, 9 February 2026.
The article first reported that a murine mixed typical intrahepatic cholangiocarcinoma (iCCA)/sarcomatoid iCCA liver tumor model with 100% incidence of spontaneous extrahepatic metastasis and confirmed the occurrence of in mouse iCCA. Most importantly, EMT induced by the TGF‐β/ZEB1 axis does not influence tumor development or distant metastasis in this
Jingwen Wang, Zijing Xu, Lei Xu, Lishan Wang, Jiahao Geng, Xue Wang, Meng Xu, Daphne Superville, Melissa Reeves, Matthias Evert, Diego F. Calvisi, Xin Chen, Xinhua Song   +12 more
wiley   +1 more source

Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells.

Kidney International, 2009
K. Raphael, K. Strait, P. Stricklett, R. Miller, R. Nelson, K. Piontek, G. Germino, D. Kohan   +7 more
semanticscholar   +1 more source

Localized cystic kidney disease: a case report unveiling clinical and histopathological challenges. [PDF]

Autops Case Rep
Mendez T, Bahmad HF, Polit F, Carpio N, Gill A, Burke WF, Bhandari A, Poppiti R, Omarzai Y.   +8 more
europepmc   +1 more source

Economic Burden of Sickle Cell Disease: A Retrospective Study of Pediatric and Adult Individuals With Medicaid Coverage From 2016 to 2020

American Journal of Hematology, Volume 101, Issue 2, Page 269-280, February 2026.
ABSTRACT There is limited information regarding the contemporary real‐world clinical and financial burden of Medicaid enrollees with sickle cell disease (SCD) in the United States. Using the IBM MarketScan Medicaid database (7/2016–12/2020), individuals with ≥ 3 SCD diagnoses were matched 1:1 on age, gender, and race to individuals without SCD ...
Giovanna Tedesco Barcelos, Telma Peixoto, Jose Alvir, Jay Lin, Christine L. Baker   +4 more
wiley   +1 more source

Quantifying variant contributions in cystic kidney disease using national-scale whole-genome sequencing. [PDF]

J Clin Invest
Sadeghi-Alavijeh O, Chan MM, Doctor GT, Voinescu CD, Stuckey A, Kousathanas A, Ho AT, Stanescu HC, Bockenhauer D, Sandford RN, Levine AP, Gale DP.   +11 more
europepmc   +1 more source