Results 101 to 110 of about 87,437 (368)
bioRxiv, 2019 Relapses driven by chemoresistant leukemic cell populations are the main cause of mortality for patients with acute myeloid leukemia (AML). Here, we show that the ectonucleotidase CD39 (ENTPD1) is upregulated in cytarabine (AraC)-resistant leukemic cells
Nesrine Aroua +30 more
semanticscholar +1 more source
Clinical Relevance of the Dose of Cytarabine in the Upfront Treatment of Primary CNS Lymphomas with Methotrexate-Cytarabine Combination [PDF]
The Oncologist, 2011 Abstract Background. The combination of high doses of methotrexate (MTX) and cytarabine (araC) is the standard chemotherapy for patients with primary CNS lymphoma (PCNSL). The addition of an alkylating agent could improve MTX-araC efficacy because it is active against quiescent G0 cells and increases ...
Ferreri AJM +12 more
openaire +4 more sources
Chemistry &Biodiversity, EarlyView.Chemical profile, photoprotective, and antioxidant potential of Padina sp., Caulerpa sertularioides, and Solieria filiformis collected in Bahia, Brazil. ABSTRACT Seaweeds have wide biotechnological applications. This study evaluated the chemical profile, photoprotective, and antioxidant potential of Padina sp., Caulerpa sertularioides, and Solieria ...
Keila Almeida Santana +8 more
wiley +1 more source
Influence of variability in starting materials quality on stability of finished drug products: a quality-by-design factor and response [PDF]
, 2012 The use of ill selected excipients in drug formulations can have a significant influence on the overall stability. Therefore, evaluation of chemical and physical excipient compatibility with the API has become a major part in the development of new drug ...
Bauters, Tieneke +5 more
core +1 more source
Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches [PDF]
, 2014 The therapeutic strategies against acute myeloid leukemia (AML) have hardly been modified over four decades. Although resulting in a favorable outcome in young patients, older individuals, the most affected population, do not respond adequately to ...
Azevedo, Maria M. +7 more
core +2 more sources
European Journal of Heart Failure, EarlyView.Specific characteristics of HFpEF universal definition in cancer patients. Abstract Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized in cancer patients and survivors, yet it remains underdiagnosed and its epidemiology largely unknown.
Kalliopi Keramida +21 more
wiley +1 more source
BiomoleculesGlioblastoma (GBM) is a difficult disease to treat for different reasons, with the blood–brain barrier (BBB) preventing therapeutic drugs from reaching the tumor being one major hurdle.
Juliette Latulippe +3 more
doaj +1 more source
Veterinary Medicine and Science, 2022 Erythroleukaemia is a malignant neoplasm of the erythroid lineage that rarely occurs in cats. It is associated with the feline leukaemia virus (FeLV), and owing to the poor prognosis, treatment is rarely reported.
Da Sol Park +3 more
doaj +1 more source
Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
International Journal of Cancer, EarlyView.Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner +3 more
wiley +1 more source
Cell Death and Disease, 2019 Acute myeloid leukemia (AML) patients display dismal prognosis due to high prevalence of refractory and relapsed disease resulting from chemoresistance. Treatment protocols, primarily based on the anchor drug Cytarabine, remained chiefly unchanged in the
M. Levin +3 more
semanticscholar +1 more source