Results 131 to 140 of about 87,437 (368)

Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling

Cell Communication and Signaling, 2019
BackgroundTreatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxicity.
Theresa Lowinus, Florian H. Heidel, Tanima Bose, S. C. Nimmagadda, T. Schnöder, Clemens Cammann, I. Schmitz, U. Seifert, T. Fischer, B. Schraven, U. Bommhardt   +10 more
semanticscholar   +1 more source

A characteristic gene expression profile regulated by ACIN1::NUTM1 fusion in a newly identified infant leukaemic cell line and an ACIN1::NUTM1‐inducible model

British Journal of Haematology, EarlyView.
An ACIN1::NUTM1‐positive ALL cell line, KOPN32, which was previously established from a relapsed infant‐ALL case, was newly identified. Comparison using 94 BCP‐ALL cell lines, an ACIN1::NUTM1‐inducible ALL model and clinical sample data revealed upregulation of HOXA9, HOXA10, SKIDA1 and BMI1, indicating direct involvement of ACIN1::NUTM1 fusion in the ...
Minori Tamai, Chiaki Komatsu, Keiko Kagami, Shin Kasai, Atsushi Watanabe, Koshi Akahane, Kumiko Goi, Chihiro Tomoyasu, Toshihiko Imamura, Satoshi Oguri, Sumio Iwasaki, Takanori Teshima, Yasushi Yatabe, Takeshi Inukai   +13 more
wiley   +1 more source

Improved outcomes in elderly patients with acute lymphoblastic leukaemia using a paediatric‐based protocol—A prospective study

British Journal of Haematology, EarlyView.
In this population‐based study the relapse rates were remarkably low in patients reaching day 79 with active treatment, challenging the widely accepted belief that ALL is difficult to cure in the elderly. Summary Population data have shown that the prognosis for elderly patients with acute lymphoblastic leukaemia (ALL) is poor, even in the modern era ...
P. Quist‐Paulsen, L. Horvei, J. Dalgaard, M. Moksnes, A. L. Eilertsen, M. Paulson, N. A. Azrakhsh, W. Majeed, H. S. Wik   +8 more
wiley   +1 more source

Cytarabine Induced Acute Cerebellar Syndrome during Hyper-CVAD Treatment for B-Cell Acute Lymphoblastic Leukemia

Case Reports in Neurology, 2017
Acute cerebellar syndrome can be caused by high doses of cytarabine, but it has not been described in patients with acute lymphoblastic leukemia (ALL) who received hyper-CVAD chemotherapy.
Phu Ngoc Tran, Xiao-Tang Kong
doaj   +1 more source

Addition of hydroxyurea (hydroxycarbamide) enhances the efficacy of fludarabine/cytarabine‐based salvage regimens against acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Left: Cells with active SAMHD1 can metabolize cytarabine (ara‐C) and fludarabine (F‐ara‐A) to their inactive precursors, limiting their cytotoxic effects. Right: Addition of hydroxyurea (hydroxycarbamide; HU) inhibits SAMHD1, leading to an increase in the active metabolites of ara‐C and F‐ara‐A and a subsequent increase in the cytotoxicity of these ...
Ingrid Lilienthal, Sijia Tao, Christer Nilsson, Elory Leonard, Runqing Zhang, Agnes L. Sorteberg, Louisa Fredrikson, Ioanna Xagoraris, Shahrzad Shirazi Fard, Nikolaos Tsesmetzis, Vasilios Zachariadis, Huan Cai, Lakshmi Sandhow, Anette Langebäck, Anna Bohlin, Katja Pokrovskaja Tamm, Sofia Bengtzén, Raymond F. Schinazi, Sören Lehmann, Baek Kim, Georgios Z. Rassidakis, Hong Qian, Martin Jädersten, Nikolas Herold   +23 more
wiley   +1 more source

microRNAs and Acute Myeloid Leukemia Chemoresistance: A Mechanistic Overview

Frontiers in Oncology, 2017
Up until the early 2000s, a functional role for microRNAs (miRNAs) was yet to be elucidated. With the advent of increasingly high-throughput and precise RNA-sequencing techniques within the last two decades, it has become well established that miRNAs can
Martino Marco Gabra, Leonardo Salmena, Leonardo Salmena   +2 more
doaj   +1 more source

Paediatric Acute Myeloid Leukaemia-Myelodysplasia Related With i(17)(q10) Morphologically Mimicking Acute Promyelocytic Leukaemia. [PDF]

EJHaem
eJHaem, Volume 6, Issue 5, October 2025.
De John K, Koen JE, De Quintal H, Lohlun R.   +3 more
europepmc   +2 more sources

Severe generalized primary herpes treated with cytarabine. [PDF]

, 1970
B. E. Juel‐Jensen
openalex   +1 more source

Reformulating acute myeloid leukemia: liposomal cytarabine and daunorubicin (CPX-351) as an emerging therapy for secondary AML

OncoTargets and Therapy, 2018
Despite increasing understanding of the pathobiology of acute myeloid leukemia (AML), outcomes remain dismal particularly for patients over the age of 60 years, a population enriched for therapy-related AML (tAML) and secondary AML (sAML).
E. Chen, A. Fathi, A. Brunner
semanticscholar   +1 more source

Prognostic significance of pretransplant 18F‐FDG PET/CT metrics in relapsed/refractory diffuse large B‐cell lymphoma with partial response to salvage chemotherapy prior to autologous stem cell transplantation

British Journal of Haematology, EarlyView.
Summary Relapsed/refractory diffuse large B‐cell lymphoma (R/R DLBCL) patients with partial response (PR) to salvage chemotherapy show heterogeneous outcomes after autologous stem cell transplantation (ASCT). Current visual positron emission tomography (PET) assessment inadequately identifies patients likely to benefit from transplantation.
Minseung Suh, Jaewon Hyung, Chan‐Sik Park, Heounjeong Go, In Hye Song, Eun Jin Chae, Kyung Won Kim, Yoon Sei Lee, Minsu Kwon, Sang‐Wook Lee, Jiwon Lee, Shin Kim, Kyoungmin Lee, Hyungwoo Cho, Jin‐Sook Ryu, Dok Hyun Yoon   +15 more
wiley   +1 more source