Results 131 to 140 of about 51,607 (296)

Glucose Metabolism as a Potential Therapeutic Target in Cytarabine-Resistant Acute Myeloid Leukemia

Pharmaceutics
Altered glycolytic metabolism has been associated with chemoresistance in acute myeloid leukemia (AML). However, there are still aspects that need clarification, as well as how to explore these metabolic alterations in therapy.
Joana Pereira-Vieira, Daniela D. Weber, Sâmia Silva, Catarina Barbosa-Matos, Sara Granja, Rui Manuel Reis, Odília Queirós, Young H. Ko, Barbara Kofler, Margarida Casal, Fátima Baltazar   +10 more
doaj   +1 more source

Relapse of Monomorphic Epitheliotropic Intestinal T‐Cell Lymphoma (MEITL) in a Pericardial Fluid

International Journal of Laboratory Hematology, EarlyView.
Elsa Bera, Liana Veresezan, Maïssa Souissi, Fanny Drieux, Pierre Lebreton, Victor Bobée   +5 more
wiley   +1 more source

Prognostic and predictive implications of sterile alpha motif and HD domain‐containing protein 1 (SAMHD1) expression in breast cancer

International Journal of Cancer, Volume 156, Issue 8, Page 1621-1633, 15 April 2025.
What's new? Sterile alpha motif and HD domain‐containing protein 1 (SAMHD1), a dNTP hydrolase, acts as tumor suppressor in cancer, but its role in breast cancer is not well‐studied. Here, the authors analyzed gene and protein expression in a cohort of patients with early breast cancer.
Maria Kouvaraki, Ioannis Zerdes, Emmanouil G. Sifakis, Michail Sarafidis, Alexios Matikas, Evangelos Tzoras, Una Kjällquist, Konstantina Stathopoulou, John Lövrot, Amjad Alkodsi, Johan Hartman, Christos Sotiriou, Francois Richard, Thomas Hatschek, Nikolas Herold, Jonas Bergh, George Z. Rassidakis, Theodoros Foukakis   +17 more
wiley   +1 more source

Butterfly Effect in Cytarabine: Combined NMR-NQR Experiment, Solid-State Computational Modeling, Quantitative Structure-Property Relationships and Molecular Docking Study

Pharmaceuticals
Cytarabine (Ara-C) is a synthetic isomer of cytidine that differs from cytidine and deoxycytidine only in the sugar. The use of arabinose instead of deoxyribose hinders the formation of phosphodiester linkages between pentoses, preventing the DNA chain ...
Jolanta Natalia Latosińska, Magdalena Latosińska, Janez Seliger, Veselko Žagar, Tomaž Apih   +4 more
doaj   +1 more source

Differential Clinical and Immunological Impacts of Anti–T‐Lymphocyte Globulin (ATLG) vs. Anti‐Thymocyte Globulin (ATG) in Preventing Graft‐Versus‐Host Disease Post‐Allogeneic Hematopoietic Stem Cell Transplantation: A Comparative Study

American Journal of Hematology, Volume 100, Issue 4, Page 626-637, April 2025.
ABSTRACT Both anti‐T‐lymphocyte globulin (ATLG‐Grafalon) and anti‐thymocyte globulin (ATG‐Thymoglobulin) prevent acute and chronic graft‐versus‐host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Despite distinct manufacturing and biological characteristics, the two brands of rabbit anti‐lymphocyte globulins have ...
Anne Beatrice Notarantonio, Stéphane Morisset, Romain Piucco, Michaël Pérès, Laura Boulangé, Alizée Alitcher, Jordan Brouard, Lucile Monchablon, Arnaud Campidelli, Siham El Ouahabi, Charles Guisnel, Charline Moulin, Céline Kicki, Gabrielle Roth‐Guepin, Pierre Feugier, Marcelo De Carvalho Bittencourt, Alice Aarnink, Maud D'Aveni‐Piney, Sébastien Hergalant, Simona Pagliuca, Marie Thérèse Rubio   +20 more
wiley   +1 more source

Cytarabine Therapy for Progressive Multifocal Leukoencephalopathy in Patients with AIDS [PDF]

, 1996
Santiago Moreno, Pilar Miralles, María Dolores Pérez Díaz, Juan Berenguer, J. C. L. Bernaldo de Quirós, R. Blázquez, Jaime Cosín, Emilio Bouza   +7 more
openalex   +1 more source

Inhibition of Adjuvant-Induced Polyarthritis with Cytarabine

Experimental Biology and Medicine, 1968
Discussion and SummaryCytarabine, like other cytotoxic drugs, inhibits the onset of adjuvant-induced polyarthritis. Both steroidal and nonsteroidal “anti-inflammatory” drugs inhibit the severity of adjuvant-induced polyarthritis 6, 7, 20. The steroids are more effective, since they inhibit not only the onset and development of the disease, but also ...
openaire   +3 more sources

Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study.

The Lancet Oncology, 2020
Seth E. Karol, Thomas B. Alexander, A. Budhraja, S. Pounds, Kristin E. Canavera, Lei Wang, J. Wolf, J. Klco, P. Mead, S. Das Gupta, S. Y. Kim, A. Salem, T. Palenski, Norman J. Lacayo, C. Pui, J. Opferman, J. Rubnitz   +16 more
semanticscholar   +1 more source

Upfront intensive treatment analysis of the Italian Cohort Study on FLT3‐mutated AML patients (FLAM): The impact of a FLT3 inhibitor addition to standard chemotherapy in the real‐life setting

Cancer, Volume 131, Issue 7, 1 April 2025.
Abstract Background The addition of a FLT3 inhibitor (FLT3i) to standard chemotherapy to treat fit newly diagnosed (ND) patients with FLT3‐mutated acute myeloid leukemia (AML) represents the standard of care resulting from clinical trial results. However, evidence regarding FLT3i adoption in routine clinical practice is still scarce.
Jacopo Nanni, Irene Azzali, Cristina Papayannidis, Antonino Mulè, Ernesta Audisio, Maria Paola Martelli, Barbara Scappini, Patrizia Chiusolo, Benedetta Cambò, Anna Candoni, Monia Lunghi, Francesco Albano, Attilio Olivieri, Nicola Fracchiolla, Massimo Bernardi, Claudio Romani, Gian Matteo Rigolin, Maria Benedetta Giannini, Monica Bocchia, Elisabetta Todisco, Daniela Cilloni, Maria Teresa Bochicchio, Emanuela Ottaviani, Agnese Mattei, Federica Zamagni, Irene Valli, Roberta Volpi, Giovanni Marconi, Elisabetta Petracci, FLAM Collaborative Group, Giovanni Martinelli   +30 more
wiley   +1 more source

THE IMMUNOSUPPRESSIVE ACTIVITY OF ARA-CYTIDINE (CYTARABINE)

, 1969
Gary D. Gray, R. J. Perper, M.M. Mickelson, John A. Crim, C F Zukowski   +4 more
openalex   +1 more source