Results 231 to 240 of about 30,296 (276)

Diazepinone Nucleosides as Inhibitors of Cytidine Deaminase.

Nucleosides and Nucleotides, 1996
Abstract The synthesis of 2′-deoxy and 2′,3′-dideoxy derivatives of 1-s-D-ribofuranosyl-1,3,4,7-tetrahydro-2H-1,3-diazepin-2-one (2) was undertaken in order to find new cytidine deaminase (CDA) inhibitors and potential adjuvants in anticancer chemotherapy.
G. Cristalli, R. Volpini, S. Vittori, CAMAIONI, Emidio, G. Rafaiani, S. Potenza, A. Vita   +6 more
openaire   +2 more sources

Cytidine Deaminase from Human Spleen

1989
No abstract ...
VITA, Alberto, Cacciamani, Tiziana, NATALINI, Paolo, RUGGIERI, Silverio, Magni, Giulio   +4 more
openaire   +3 more sources

Cytidine deaminase activity in abnormal pregnancy

International Journal of Gynecology & Obstetrics, 1993
AbstractOBJECTIVE: To determine the usefulness of cytidine deaminase (CTD) activity in the prediction of abnormal pregnancy and the prognosis of fetal outcome. METHOD: The CTD activities in 367 pregnant women and 17 placentas and their cord sera were determined.
T, Okamura, K, Kigasawa, T, Takeuchi, C, Ohta   +3 more
openaire   +2 more sources

Activation-induced cytidine deaminase and active cytidine demethylation

Trends in Biochemical Sciences, 2015
The regulation of demethylation in vertebrates has begun to be elucidated in the past decade. However, a possible involvement of activation-induced cytidine deaminase (AID) in this process remains uncertain. We survey the data supporting or casting doubt on such a role, and propose that there is no strong evidence for an involvement of AID in genome ...
Almudena R, Ramiro, Vasco M, Barreto
openaire   +2 more sources

Studies on Thermal Stability of Human Cytidine Deaminase

Nucleosides, Nucleotides & Nucleic Acids, 2007
The thermal stability of human cytidine deaminase (CDA), an enzyme involved in pyrimidine metabolism was investigated. With this in view, the residues R68 and Y60, supposed to be involved in the intersubunit interactions and in the catalytic site of CDA, were mutated to glutamine and glycine, respectively.
VINCENZETTI, Silvia, PUCCIARELLI, Stefania, MARIANI P., DE SANCTIS, Giampiero, POLZONETTI, Valeria, NATALINI, Paolo, VITA, Alberto   +6 more
openaire   +2 more sources

Crystal structure of Arabidopsis thaliana cytidine deaminase

Biochemical and Biophysical Research Communications, 2020
Cytidine deaminase (CDA) catalyzes the (deoxy)cytidine deamination to (deoxy)uridine, which involves in the catabolic and salvage pathways of pyrimidine nucleotides in plants. CDA serves as a prototype of the cytidine deaminase superfamily that contains a number of RNA editing enzymes. Arabidopsis thaliana has only one functional CDA, AtCDA1. We solved
Jia Wang, Qi Guo, Lin Liu, Xiao Wang
openaire   +2 more sources

Human Cytidine Deaminase: Understanding the Catalytic Mechanism

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
COSTANZI S, VINCENZETTI, Silvia, VITA, Alberto, LAMBERTUCCI, Catia, TAFFI S, VOLPINI, Rosaria, VITTORI, Sauro, CRISTALLI, Gloria   +7 more
openaire   +2 more sources

Activity of serum cytidine deaminase during pregnancy

BJOG: An International Journal of Obstetrics & Gynaecology, 1982
Summary. A simple and reliable method for the estimation of cytidine deaminase (cytidine aminohydrolase; EC 3.5.4.5) activity in pregnancy serum is described. This enzyme does not require magnesium for activation and is also more stable than deoxycytidylate deaminase (dCMP deaminase, dCMP aminohydrolase; EC 3.5.4.12).
D D, Jones, S, Bahijri, E L, Roberts, G F, Williams   +3 more
openaire   +2 more sources

The role of activation-induced cytidine deaminase in lymphomagenesis

Current Opinion in Hematology, 2012
Activation-induced cytidine deaminase (AID) is expressed in germinal center B cells and initiates the events that lead to somatic hypermutation and class switch recombination of immunoglobulin genes. In addition to this fundamental role in immune diversification, aberrant targeting of AID activity contributes to point mutations and translocations of ...
Xiwen, Gu, Velizar, Shivarov, Matthew P, Strout   +2 more
openaire   +2 more sources

Cytidine and deoxycytidylate deaminase inhibition by uridine analogs

Biochemical Pharmacology, 1980
Cytidine deaminase, an enzyme found in the supernatant fluid of hepatocytes, granulocytes and tumor cells, and in plasma, degrades the antitumor agents cytosine arabinoside and 5-azacytidine. Uridine and its analogs, 3-deazauridine, 5-bromodeoxyuridine, 5-fluorodeoxyuridine and 6-azauridine, were found to competitively inhibit cytidine deaminase; the ...
J C, Drake, K R, Hande, R W, Fuller, B A, Chabner   +3 more
openaire   +2 more sources