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Multifaceted antiviral actions of APOBEC3 cytidine deaminases
Trends in Immunology, 2006To defend against external pathogens, metazoan organisms have evolved numerous defenses that generally fall within the innate and adaptive immune responses. Considerable effort continues to focus on developing a vaccine to manipulate the adaptive immune system to protect against or control HIV-1.
Ya-Lin, Chiu, Warner C, Greene
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Action of bacterial cytidine deaminase on 5,6-dihydrocytidine
Biochemistry, 1975Cytidine deaminase from Escherichia coli was found to catalyze the hydrolytic deamination of 5,6-dihydrocytidine, at a rate slightly lower than its rate of action on the normal substrate. The results suggest that nucleophilic addition by the enzyme at the 5,6 position of the substrate is not an essential part of catalysis, unless the active site is so ...
B E, Evans, G N, Mitchell, R, Wolfenden
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On the Role of Cytidine Deaminase in Cellular Metabolism
1986Pyrimidine nucleotides are synthesized either denovo or via salvage pathways from preformed pyrimidine compounds. The denovo pathway of UTP and CTP synthesis appears to be almost identical in the various organisms studied, while there are major differences in the pathways by which pyrimidine deoxynu-cleotides are synthesized.
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Determination of plasma cytidine deaminase activity by HPLC
Biomedical Chromatography, 1987AbstractCytidine deaminase is an enzyme of nucleic acid metabolism, the measurement of which has been proposed as a useful test for the early detection of pre‐eclamptic toxaemia in pregnancy. The enzyme converts the nucleoside cytidine to uridine, with the release of ammonia, and it is the measurement of this latter compound that forms the basis of the
D A, Richards +3 more
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Base editing with a Cpf1–cytidine deaminase fusion
Nature Biotechnology, 2018The targeting range of CRISPR-Cas9 base editors (BEs) is limited by their G/C-rich protospacer-adjacent motif (PAM) sequences. To overcome this limitation, we developed a CRISPR-Cpf1-based BE by fusing the rat cytosine deaminase APOBEC1 to a catalytically inactive version of Lachnospiraceae bacterium Cpf1.
Xiaosa Li +11 more
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Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase
Nature Structural & Molecular Biology, 2008Deamination of cytidine residues in single-stranded DNA (ssDNA) is an important mechanism by which apolipoprotein B mRNA-editing, catalytic polypeptide-like (APOBEC) enzymes restrict endogenous and exogenous viruses. The dynamic process underlying APOBEC-induced hypermutation is not fully understood.
Roni, Nowarski +3 more
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Transfer of the cytidine deaminase cDNA into hematopoietic cells
Leukemia Research, 1999In order to investigate whether transfer of the cytidine deaminase (CDD) cDNA would increase chemotherapy resistance to cytosine arabinoside (ara-C) we used a retroviral vector expressing both, neomycin phosphotransferase and the CDD cDNA, to transduce hematopoietic cells from cell lines and from murine bone marrow (BM).
M, Flasshove +5 more
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Cytidine Deaminase and the Development of Resistance to Arabinosyl Cytosine
Nature New Biology, 1971THE effectiveness of arabinosyl cytosine (cytarabine: 1-β-D-arabinofuranosylcytosine, ‘Cytosar’, abbreviated to ara-C) in the treatment of human leukaemia can be correlated with the rate of uptake of the molecule in vitro1 and its subsequent phosphorylation.
C D, Steuart, P J, Burke
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The cytidine deaminase family: a review
2009in ...
VINCENZETTI, Silvia +2 more
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