Results 91 to 100 of about 7,415 (242)

Plasmodium falciparum Plasmodium helical interspersed subtelomeric proteins contribute to cytoadherence and anchor P. falciparum erythrocyte membrane protein 1 to the host cell cytoskeleton

Cellular Microbiology, 2016
Adherence of Plasmodium falciparum‐infected erythrocytes to host endothelium is conferred through the parasite‐derived virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1), the major contributor to malaria severity.
Alexander Oberli, Laura Zurbrügg, Sebastian Rusch, Françoise Brand, M. E. Butler, J. Day, E. Cutts, T. Lavstsen, I. Vakonakis, H. Beck   +9 more
semanticscholar   +1 more source

The role of ICAM-1 in Plasmodium falciparum cytoadherence

European Journal of Cell Biology, 2005
Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1) and its role in mediating the interaction between the parasitised red blood cell (PRBC) and the ...
Alister Craig, Srabasti J. Chakravorty
openaire   +3 more sources

An image-based drug susceptibility assay targeting the placental sequestration of Plasmodium falciparum-infected erythrocytes. [PDF]

PLoS ONE, 2012
Placental malaria is a significant cause of all malaria-related deaths globally for which no drugs have been developed to specifically disrupt its pathogenesis.
Min-Je Ku, Fernando de M Dossin, Michael A E Hansen, Auguste Genovesio, Lawrence Ayong, Lucio H Freitas-Junior   +5 more
doaj   +1 more source

An Analysis of the Binding Characteristics of a Panel of Recently Selected ICAM-1 Binding Plasmodium falciparum Patient Isolates. [PDF]

, 2014
The basis of severe malaria pathogenesis in part includes sequestration of Plasmodium falciparum-infected erythrocytes (IE) from the peripheral circulation.
Alharthi, Saeed, Alkurbi, Mohammed O., Bengtsson, Anja, Craig, Alister, Jensen, Anja T R, Madkhali, Aymen M., Patil, Pradeep R, Pleass, Richard, Szestak, Tadge, Wu, Yang   +9 more
core   +3 more sources

Pro‐ and anti‐inflammatory cytokines mediate the progression of severe anemia in malaria‐infected children: A prospective study

Immunity, Inflammation and Disease, Volume 12, Issue 9, September 2024.
Abstract Background Severe Plasmodium falciparum malarial anemia is still the principal cause of death in children in underdeveloped countries. An imbalance between proinflammatory and anti‐inflammatory cytokines is associated with malaria progression.
Charles Nkansah, Felix Osei‐Boakye, Gabriel Abbam, Samuel K. Appiah, Samira Daud, Bright Boakye, Samsiyatu Abdulai, Madina Ahmed, Theophilus B. Antwi, Birago Boateng, Miigbat P. Libatin, Alexander S. Mensah, Mary K. Missah, Richard V. Duneeh, Ashiya Haruna, Stephany Adda, Pagnaa G. Abdul‐Rauf, Zacharia A. Ofori, George B. Fosu, Sandra Segnitome, Isaac Adjei, Emmanuel Appiah‐Kubi, Moses Banyeh, Charles A. Derigubah, Muniru M. Tanko, Ejike F. Chukwurah   +25 more
wiley   +1 more source

Comparison of apoptosis in human primary pulmonary endothelial cells and a brain microvascular endothelial cell line co-cultured with Plasmodium falciparum field isolates

BMC Infectious Diseases, 2017
Background Plasmodium falciparum infection can progress unpredictably to severe forms including respiratory distress and cerebral malaria. The mechanisms underlying the variable natural course of malaria remain elusive. Methods The cerebral microvascular
Jean Claude Biteghe Bi Essone, Nadine N’Dilimabaka, Julien Ondzaga, Jean Bernard Lekana-Douki, Dieudonné Nkoghe Mba, Philippe Deloron, Dominique Mazier, Frédrérick Gay, Fousseyni S. Touré Ndouo   +8 more
doaj   +1 more source

Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor. [PDF]

PLoS ONE, 2011
IntroductionSevere malaria has been attributed partly to the sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the microvasculature of vital host organs. Identification of P.
Alfredo Mayor, Abdul Hafiz, Quique Bassat, Eduard Rovira-Vallbona, Sergi Sanz, Sónia Machevo, Ruth Aguilar, Pau Cisteró, Betuel Sigaúque, Clara Menéndez, Pedro L Alonso, Chetan E Chitnis   +11 more
doaj   +1 more source

Surface antigens in Plasmodium falciparum malaria : PfEMP1 and SURFIN4.2 [PDF]

, 2017
Plasmodium falciparum malaria is an infectious disease that on despite of the ongoing eradication efforts is still endemic in more than 100 countries, sometimes causing severe disease that leads to the death of around half a million people per year ...
Quintana Varon, Maria del Pilar
core   +1 more source

Lactobacillus gasseri and Gardnerella vaginalis produce extracellular vesicles that contribute to the function of the vaginal microbiome and modulate host–Trichomonas vaginalis interactions

Molecular Microbiology, Volume 122, Issue 3, Page 357-371, September 2024.
Our study investigates the influence of extracellular vesicles, released by two bacterial species of the human cervicovaginal microbiome, on the infection by Trichomonas vaginalis. We described species‐specific protein cargoes of these vesicles matching the expected contribution of the bacteria to this biome.
Anastasiia Artuyants, Jiwon Hong, Priscila Dauros‐Singorenko, Anthony Phillips, Augusto Simoes‐Barbosa   +4 more
wiley   +1 more source

Association between Endothelial Selectin (E-selectin) gene polymorphisms and E-selectin level with visceral leishmaniais, in an ARMS-PCR based study [PDF]

, 2008
Background: In the visceral leishmaniasis (VL), parasites reside in reticuluendothelial system, mainly in macrophages. Endothelial Selectin (E-selectin) might play an important role in leukocyte-endothelium interactions and inflammatory cell recruitment.
Bazmani, A., Fallah, M., Hajilooi, M., Mazloumi Gavgani, A., Taherkhani, H.   +4 more
core