Results 91 to 100 of about 6,252 (195)

A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria. [PDF]

PLoS ONE, 2011
In Africa, infant susceptibility to Plasmodium falciparum malaria increases substantially as fetal hemoglobin (HbF) and maternal immune IgG disappear from circulation.
Chanaki Amaratunga, Tatiana M Lopera-Mesa, Nathaniel J Brittain, Rushina Cholera, Takayuki Arie, Hisashi Fujioka, Jeffrey R Keefer, Rick M Fairhurst   +7 more
doaj   +1 more source

Intravital placenta imaging reveals microcirculatory dynamics impact on sequestration and phagocytosis of Plasmodium-infected erythrocytes [PDF]

, 2013
Malaria in pregnancy is exquisitely aggressive, causing a range of adverse maternal and fetal outcomes prominently linked to Plasmodium-infected erythrocyte cytoadherence to fetal trophoblast. To elucidate the physiopathology of infected erythrocytes (IE)
Gómez-Conde, Ivan, Moraes, Luciana Vieira de, Olivieri, David N., Penha-Gonçalves, Carlos, Tadokoro, Carlos Eduardo   +4 more
core   +3 more sources

Monocyte‐derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF‐β1

Journal of Extracellular Vesicles, Volume 13, Issue 11, November 2024.
Abstract During cell invasion, large Extracellular Vesicle (lEV) release from host cells was dose‐dependently triggered by Trypanosoma cruzi metacyclic trypomastigotes (Mtr). This lEV release was inhibited when IP3‐mediated Ca2+ exit from the ER and further Ca2+ entry from plasma membrane channels was blocked, but whilst any store‐independent Ca2 ...
Ephraim A. Ansa‐Addo, Paras Pathak, Maria V. McCrossan, Izadora Volpato Rossi, Mahamed Abdullahi, Dan Stratton, Sigrun Lange, Marcel I. Ramirez, Jameel M. Inal   +8 more
wiley   +1 more source

High plasma levels of soluble intercellular adhesion molecule (ICAM)-1 are associated with cerebral malaria. [PDF]

PLoS ONE, 2013
BackgroundCerebral malaria (CM) is responsible for most of the malaria-related deaths in children in sub-Saharan Africa. Although, not well understood, the pathogenesis of CM involves parasite and host factors which contribute to parasite sequestration ...
Selorme Adukpo, Kwadwo A Kusi, Michael F Ofori, John K A Tetteh, Daniel Amoako-Sakyi, Bamenla Q Goka, George O Adjei, Dominic A Edoh, Bartholomew D Akanmori, Ben A Gyan, Daniel Dodoo   +10 more
doaj   +1 more source

Antibodies to specific domains of Plasmodium falciparum erythrocyte membrane protein‐1 and its relationship with protection from severe malarial anemia: A prospective study among Ghanaian children

Health Science Reports, Volume 7, Issue 10, October 2024.
Abstract Background Plasmodium falciparum erythrocyte membrane protein‐1 (PfEMP‐1) is important in malaria pathogenicity as it mediates Pf‐infected erythrocytes cytoadherence to host endothelial microvasculature receptors. Naturally acquired antibodies against specific PfEMP‐1 antigens may be beneficial in clinical malaria protection.
Charles Nkansah, Felix Osei‐Boakye, Gabriel Abbam, Samuel K. Appiah, Charles A. Derigubah, Simon B. Bani, Samira Daud, Emmanuel K. Alhassan, Isaac Adjei, Emmanuel Appiah‐Kubi, Anastasia Koduah, Bright Boakye, Samsiyatu Abdulai, Neena I. Anass, Dorcas Serwaa, Boniface N. Ukwah, Victor U. Usanga, Ejike F. Chukwurah   +17 more
wiley   +1 more source

Inhibition of Plasmodium falciparum field isolates-mediated endothelial cell apoptosis by Fasudil: therapeutic implications for severe malaria. [PDF]

PLoS ONE, 2010
Plasmodium falciparum infection can abruptly progress to severe malaria, a life-threatening complication resulting from sequestration of parasitized red blood cells (PRBC) in the microvasculature of various organs such as the brain and lungs.
Estelle S Zang-Edou, Ulrick Bisvigou, Zacharie Taoufiq, Faustin Lékoulou, Jean Bernard Lékana-Douki, Yves Traoré, Dominique Mazier, Fousseyni S Touré-Ndouo   +7 more
doaj   +1 more source

Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling [PDF]

, 2011
Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling.
Abdi, Agarwal, Allen, Anamika, Behnke, Billker, Billker, Bishop, Blethrow, Bracchi-Ricard, Bradley, Brian M. Cooke, Butcher, Carruthers, Carvalho, Christian Doerig, Cooke, Cooke, Coppi, Dalpke, Daniel C. Lim, Dar, Doerig, Doerig, Doerig, Dorin, Dorin, Dorin, Droucheau, El Hajj, Fennell, Fentress, Gilbert, Green, Gueirard, Halbert, Hanks, Huse, Hutti, Ishino, Jensen, Jeroen P.J. Saeij, Kafsack, Kannan, Kato, Khaminets, Khan, Khan, Khan, Kieschnick, Kun, Kuo, Labesse, Ling, Lodoen, Lourido, Luder, Manning, Martens, Melzer, Nagamune, Nunes, Nunes, Ojo, Ong, Parsons, Peixoto, Pernas, Qiu, Reese, Reese, Reese, Reininger, Reininger, Reininger, Rosenberg, Rosowski, Saeij, Saeij, Scheibel, Schneider, Shiels, Sicard, Singh, Singh, Solyakov, Sopko, Steinfeldt, Sugi, Suss-Toby, Taylor, Taylor, Tewari, Vaid, van de Sand, Ward, Ward, Wernimont, Wernimont, Xu, Yamamoto, Yasukawa, Zeqiraj, Zeqiraj, Zhao, Zhao   +105 more
core   +2 more sources

Pro‐ and anti‐inflammatory cytokines mediate the progression of severe anemia in malaria‐infected children: A prospective study

Immunity, Inflammation and Disease, Volume 12, Issue 9, September 2024.
Abstract Background Severe Plasmodium falciparum malarial anemia is still the principal cause of death in children in underdeveloped countries. An imbalance between proinflammatory and anti‐inflammatory cytokines is associated with malaria progression.
Charles Nkansah, Felix Osei‐Boakye, Gabriel Abbam, Samuel K. Appiah, Samira Daud, Bright Boakye, Samsiyatu Abdulai, Madina Ahmed, Theophilus B. Antwi, Birago Boateng, Miigbat P. Libatin, Alexander S. Mensah, Mary K. Missah, Richard V. Duneeh, Ashiya Haruna, Stephany Adda, Pagnaa G. Abdul‐Rauf, Zacharia A. Ofori, George B. Fosu, Sandra Segnitome, Isaac Adjei, Emmanuel Appiah‐Kubi, Moses Banyeh, Charles A. Derigubah, Muniru M. Tanko, Ejike F. Chukwurah   +25 more
wiley   +1 more source

Aptamer Technology: Adjunct Therapy for Malaria

Biomedicines, 2017
Malaria is a life-threatening parasitic infection occurring in the endemic areas, primarily in children under the age of five, pregnant women, and patients with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV)/(AIDS) as well as ...
Nik Abdul Aziz Nik Kamarudin, Nurul Adila Mohammed, Khairul Mohd Fadzli Mustaffa   +2 more
doaj   +1 more source

Lactobacillus gasseri and Gardnerella vaginalis produce extracellular vesicles that contribute to the function of the vaginal microbiome and modulate host–Trichomonas vaginalis interactions

Molecular Microbiology, Volume 122, Issue 3, Page 357-371, September 2024.
Our study investigates the influence of extracellular vesicles, released by two bacterial species of the human cervicovaginal microbiome, on the infection by Trichomonas vaginalis. We described species‐specific protein cargoes of these vesicles matching the expected contribution of the bacteria to this biome.
Anastasiia Artuyants, Jiwon Hong, Priscila Dauros‐Singorenko, Anthony Phillips, Augusto Simoes‐Barbosa   +4 more
wiley   +1 more source