Results 1 to 10 of about 28,910 (233)
Cytokines and Chemokines in Cerebral Malaria Pathogenesis
Frontiers in Cellular and Infection Microbiology, 2017 Cerebral malaria is among the major causes of malaria-associated mortality and effective adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes involved in the development of cerebral malaria include an imbalance of
Josefine Dunst +7 more
doaj +3 more sources
Brain Research Bulletin, 2019 Malaria remains of significant public health concern under the tropics, causing millions of deaths annually. The disease is caused by protozoans of the Plasmodium genus, of which harbors several distinct species. Human infection occurs during the blood meal of an infected female mosquito belonging to the Anopheles genus.
Ange Landela Luzolo +1 more
exaly +3 more sources
Lancet, The, 1990 Cerebral malaria is a rapidly progressive encephalopathy with up to 50% mortality. A cardinal feature is the massing of red cells containing mature Plasmodium falciparum within the cerebral capillaries. Adhesion of these parasitised red cells to endothelium, an event which may initiate cerebral malaria, is being studied at the molecular level. However,
R E Phillips, Tom Solomon
exaly +4 more sources
NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients [PDF]
PeerJ, 2018 Background Host factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 ...
Alassane Thiam +12 more
doaj +2 more sources
BIOMARKERS AND PROGNOSTIC SCORING IN CEREBRAL MALARIA
Malang Neurology Journal, 2022 Malaria remains a public health concern and remain the deadliest in infectious disease in the world. Cerebral malaria is a particularly severe complication of this disease and associated with high mortality.
Orlando Pikatan +3 more
doaj +1 more source
Cerebral malaria and the story of Quinine and the Fever Trees
Advances in Clinical Neuroscience & Rehabilitation, 2020 Cinchona bark was first recorded as a cure for malaria by the Spanish in Peru around 1630. A Spanish missionary allegedly learned of the treatment from the Indian natives.
JMS Pearce
doaj +1 more source
Practical Neurology, 2004 Successful management of cerebral malaria requires rapid diagnosis, initiation of appropriate antimalarial agents, and aggressive supportive care. The antimalarial used will depend on drug availability, with many of the most effective agents not routinely available in the US.
openaire +3 more sources
Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. [PDF]
PLoS Pathogens, 2012 Cerebral malaria is a major, life-threatening complication of Plasmodium falciparum malaria, and has very high mortality rate. In murine malaria models, natural killer (NK) cell responses have been shown to play a crucial role in the pathogenesis of ...
Kouyuki Hirayasu +13 more
doaj +1 more source
Association of ADAMTS13 polymorphism with cerebral malaria
Malaria Journal, 2011 Background Cerebral malaria is one of the most severe manifestations of Plasmodium falciparum malaria. The sequestration of parasitized red blood cells (PRBCs) to brain microvascular endothelium has been shown to contribute to the pathophysiology of ...
Kraisin Sirima +7 more
doaj +1 more source
Cytokine response during non-cerebral and cerebral malaria: evidence of a failure to control inflammation as a cause of death in African adults [PDF]
PeerJ, 2016 Background. With 214 million cases and 438,000 deaths in 2015, malaria remains one of the deadliest infectious diseases in tropical countries. Several species of the protozoan Plasmodium cause malaria.
Yakhya Dieye +8 more
doaj +2 more sources