Results 1 to 10 of about 1,080,036 (179)
Advanced Science, 2022 Reorganization of host red blood cells by the malaria parasite Plasmodium falciparum enables their sequestration via attachment to the microvasculature.
Oscar Bate Akide Ndunge +2 more
doaj +2 more sources
Cytokines and Chemokines in Cerebral Malaria Pathogenesis
Frontiers in Cellular and Infection Microbiology, 2017 Cerebral malaria is among the major causes of malaria-associated mortality and effective adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes involved in the development of cerebral malaria include an imbalance of
Josefine Dunst +7 more
doaj +2 more sources
Cerebral malaria is associated with differential cytoadherence to brain endothelial cells
EMBO Molecular Medicine, 2019 Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow adhesion assay with TNF‐activated primary human microvascular endothelial cells, we ...
Christopher A Moxon +2 more
exaly +2 more sources
Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria
Cell Host and Microbe, 2017 Summary Brain swelling is the major predictor of mortality in pediatric cerebral malaria (CM). However, the mechanisms leading to swelling remain poorly defined. Here, we combined neuroimaging, parasite transcript profiling, and laboratory blood profiles
Maria Bernabeu +2 more
exaly +2 more sources
EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria.
PLoS Pathogens, 2020 Disruption of blood-brain barrier (BBB) function is a key feature of cerebral malaria. Increased barrier permeability occurs due to disassembly of tight and adherens junctions between endothelial cells, yet the mechanisms governing junction disassembly ...
Thayer K Darling +9 more
doaj +2 more sources
Immunity, 2018 SUMMARY Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood cells.
Stephen C Jameson +2 more
exaly +2 more sources
Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice. [PDF]
PLoS ONE, 2017 A devastating complication of Plasmodium falciparum infection is cerebral malaria, in which vascular leakage and cerebral swelling lead to coma and often death. P. falciparum produces a protein called histidine-rich protein II (HRPII) that accumulates to
Priya Pal +5 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2022 Cerebral malaria (CM) caused by Plasmodium falciparum is a fatal neurological complication of malaria, resulting in coma and death, and even survivors may suffer long-term neurological sequelae.
Xiaonan Song +6 more
semanticscholar +1 more source
Cerebral Malaria: Current Clinical and Immunological Aspects
Frontiers in Immunology, 2022 This review focuses on current clinical and immunological aspects of cerebral malaria induced by Plasmodium falciparum infection. Albeit many issues concerning the inflammatory responses remain unresolved and need further investigations, current ...
K. Albrecht-Schgoer +3 more
semanticscholar +1 more source
Journal of Experimental Medicine, 2021 Plasmodium falciparum parasites causing cerebral malaria express specific PfEMP1 proteins (group A+CM) on infected erythrocytes. Group A+CM PfEMP1s allow entry into brain microvascular endothelial cells; this causes cell swelling and drives cerebral ...
Yvonne Adams +11 more
semanticscholar +1 more source