Results 11 to 20 of about 1,645,602 (269)

Heparin in the treatment of cerebral malaria.

Paediatrica Indonesiana, 2021
Cerebral episodes in malaria are considered to be due to thrombin in the cerebral capillaries. Heparin is beneficial in arterial thrombosis, not only on account of its anticoagulating property, but also by virtue of its slight vasodilating effect which ...
M. Munir, H. Tjandra, T. Rampengan, I. Mustadjab, F. H. Wulur   +4 more
semanticscholar   +1 more source

NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients [PDF]

PeerJ, 2018
Background Host factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 ...
Alassane Thiam, Sabrina Baaklini, Babacar Mbengue, Samia Nisar, Maryam Diarra, Sandrine Marquet, Mouhamadou Mansour Fall, Michel Sanka, Fatou Thiam, Rokhaya Ndiaye Diallo, Magali Torres, Alioune Dieye, Pascal Rihet   +12 more
doaj   +2 more sources

Malaria parasite heme biosynthesis promotes and griseofulvin protects against cerebral malaria in mice

Nature Communications, 2022
Heme-biosynthetic pathway of malaria parasite is dispensable for asexual stages, but essential for mosquito and liver stages. Despite having backup mechanisms to acquire hemoglobin-heme, pathway intermediates and/or enzymes from the host, asexual ...
M. Chandana, Aditya Anand, Sourav Ghosh, Rahul Das, Subhashree Beura, Sarita Jena, A. Suryawanshi, G. Padmanaban, V. A. Nagaraj   +8 more
semanticscholar   +1 more source

BIOMARKERS AND PROGNOSTIC SCORING IN CEREBRAL MALARIA

Malang Neurology Journal, 2022
Malaria remains a public health concern and remain the deadliest in infectious disease in the world. Cerebral malaria is a particularly severe complication of this disease and associated with high mortality.
Orlando Pikatan, Ellen Ferlita Tirtana, Kezia Seraphine, Wienta Diarsvitri   +3 more
doaj   +1 more source

Association of Plasma Tau With Mortality and Long-term Neurocognitive Impairment in Survivors of Pediatric Cerebral Malaria and Severe Malarial Anemia

JAMA Network Open, 2021
Key Points Question Are plasma tau levels associated with long-term neurocognitive impairment in pediatric cerebral malaria or severe malarial anemia? Findings In this cohort study of 467 children in Uganda, including children with cerebral malaria and ...
D. Datta, P. Bangirana, R. Opoka, A. Conroy, K. Co, C. Bond, Yi Zhao, Keisuke Kawata, A. Saykin, Chandy C. John   +9 more
semanticscholar   +1 more source

Cerebral malaria and the story of Quinine and the Fever Trees

Advances in Clinical Neuroscience & Rehabilitation, 2020
Cinchona bark was first recorded as a cure for malaria by the Spanish in Peru around 1630. A Spanish missionary allegedly learned of the treatment from the Indian natives.
JMS Pearce
doaj   +1 more source

Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. [PDF]

PLoS Pathogens, 2012
Cerebral malaria is a major, life-threatening complication of Plasmodium falciparum malaria, and has very high mortality rate. In murine malaria models, natural killer (NK) cell responses have been shown to play a crucial role in the pathogenesis of ...
Kouyuki Hirayasu, Jun Ohashi, Koichi Kashiwase, Hathairad Hananantachai, Izumi Naka, Atsuko Ogawa, Minoko Takanashi, Masahiro Satake, Kazunori Nakajima, Peter Parham, Hisashi Arase, Katsushi Tokunaga, Jintana Patarapotikul, Toshio Yabe   +13 more
doaj   +1 more source

Cerebral Malaria [PDF]

Practical Neurology, 2004
Successful management of cerebral malaria requires rapid diagnosis, initiation of appropriate antimalarial agents, and aggressive supportive care. The antimalarial used will depend on drug availability, with many of the most effective agents not routinely available in the US.
openaire   +3 more sources

Pathophysiology and neurologic sequelae of cerebral malaria

Malaria Journal, 2020
Cerebral malaria (CM), results from Plasmodium falciparum infection, and has a high mortality rate. CM survivors can retain life-long post CM sequelae, including seizures and neurocognitive deficits profoundly affecting their quality of life.
N. Schiess, Andres Villabona-Rueda, Karissa E. Cottier, Katherine Huether, J. Chipeta, M. Stins   +5 more
semanticscholar   +1 more source

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease. [PDF]

, 2009
Cerebral malaria is a life-threatening complication of malaria infection. The pathogenesis of cerebral malaria is poorly defined and progress in understanding the condition is severely hampered by the inability to study in detail, ante-mortem, the ...
KEVIN N. COUPER, Couper, Kevin N, Riley, Eleanor M, Hafalla, Julius CR, Brian De Souza, J., Hafalla, Julius C R, Couper, Kevin N., JULIUS C. R. HAFALLA, de Souza, J Brian, Riley, Eleanor M., ELEANOR M. RILEY, J. BRIAN de SOUZA   +11 more
core   +1 more source