Results 41 to 50 of about 28,910 (233)

The Economic Costs of Malaria in Children in three Sub-Saharan Countries: Ghana, Tanzania and Kenya. [PDF]

, 2013
Malaria causes significant mortality and morbidity in sub-Saharan Africa (SSA), especially among children less than five years of age (U5 children).
Sicuri, E, Constenla, Dagna, Dagna Constenla, Elisa Sicuri, Sicuri, Elisa, Vieta, Ana, Constenla, D, Christophe Sauboin, Lindner, Leandro, Vieta, A, Ana Vieta, Lindner, L, Sauboin, C, Sauboin, Christophe, Leandro Lindner   +14 more
core   +1 more source

Cerebral malaria

Biomedicine & Pharmacotherapy, 1989
Cerebral malaria is the most important manifestation of severe Plasmodium falciparum infection. The clinical picture in South East Asian adults differs from that in African children. The children are more likely to have abnormal brain stem reflexes, signs suggestive of cerebral herniation, and raised CSF opening pressure, and to suffer persistent ...
openaire   +4 more sources

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. [PDF]

, 2011
BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation.
Amanda Leach, Bejon, P, Walter Otieno, Kabore, W, Solange Soulanoudjingar, Njuguna, Patricia, Daniel Ansong, Kwaku Asante, Sacarlal, J, Soulanoudjingar, Solange, Ansong, D, Greenwood, Brian, Leach, Amanda, Samwel Gesase, Gesase, Samwel, Schellenberg, D, Patricia Njuguna, Bejon, Philip, Evans, Jennifer, Greenwood, B, Ansong, Daniel, Asante, KP, Clinical Trials Partnership Committee, null null, Mary J Hamel, Leach, A, Hamel, Mary J, Salim, N, Jennifer Evans, Jahit Sacarlal, Sacarlal, Jahit, Njuguna, P, Kwaku Poku Asante, Schellenberg, David, Kamthunzi, P, Gesase, S, Kevin Marsh, Asante, Kwaku Poku, Hamel, MJ, Evans, J, Portia Kamthunzi, Vekemans, J, Brian Greenwood, Vekemans, Johan, Philip Bejon, Kamthunzi, Portia, Marsh, K, Otieno, Walter, David Schellenberg, Nahya Salim, William Kabore, Otieno, W, Kabore, William, Salim, Nahya, Soulanoudjingar, S, Marsh, Kevin, Johan Vekemans   +56 more
core   +1 more source

Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria

Memorias do Instituto Oswaldo Cruz, 1992
Although several animal models for human cerebral malaria have been proposed in the past, name have shown pathological findings that are similar to those seen in humans.
Masamichi Aikawa, Arthur E. Brown, C. Dahlem Smith, Tatsuya Tegoshi, Russell J. Howard, Thomas H. Hasler, Yoshihiro Ito, William E. Colins, H. Kyle Webster   +8 more
doaj   +1 more source

Elevated plasma von Willebrand factor and propeptide levels in Malawian children with malaria. [PDF]

PLoS ONE, 2011
In spite of the significant mortality associated with Plasmodium falciparum infection, the mechanisms underlying severe disease remain poorly understood.
Happy T Phiri, Daniel J Bridges, Simon J Glover, Jan A van Mourik, Bas de Laat, Bridon M'baya, Terrie E Taylor, Karl B Seydel, Malcolm E Molyneux, E Brian Faragher, Alister G Craig, James E G Bunn   +11 more
doaj   +1 more source

Quantitative electroencephalographic measures during postmalarial epileptogenesis

Epilepsia, EarlyView.
Abstract Objective Severe malaria with neurologic involvement contributes significantly to the global burden of acquired pediatric epilepsy. We studied quantitative electroencephalographic (EEG) measures in postmalarial epileptogenesis. Methods A total of 186 patients, aged 6 months to 11 years, with confirmed central nervous system malaria were ...
Rasesh B. Joshi, Suzanna Mwanza, Hitten P. Zaveri, Joseph Kasolo, Angela Masempela, Thelma Musakanya, Tina Mwale, Violet Nambeye, Rosemary Nyriongo, Ruth A. Tembo, Christopher Cortina, Bo Zhang, Gretchen L. Birbeck, Alexander Rotenberg, Archana A. Patel   +14 more
wiley   +1 more source

Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia

, 2006
The Plasmodium falciparum variant erythrocyte surface antigens known as PfEMP1, encoded by the var gene family, are thought to play a crucial role in malaria pathogenesis because they mediate adhesion to host cells and immuno-modulation.
Thera, Mahamadou A, Stone, Graham N, Koné, Abdoulaye K, Challis, Richard J, Lyke, Kirsten E, Rowe, J Alexandra; id_orcid, Kyriacou, Helen M, Raza, Ahmed, Doumbo, Ogobara K, Plowe, Christopher V   +9 more
core   +1 more source

Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-γ as contributing to enhanced malaria surviva [PDF]

, 2010
The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have used a mouse model to detect genes involved in the resistance or susceptibility to Plasmodium ...
Winzeler, E.A., Wiltshire, T., Selina E R Bopp, Waters Andrew P., Andrew P. Waters, Luzader, A., Bopp, S.E.R., Waters, A.P., Steffy Brian M., Henson Kerstin, Winzeler Elizabeth A., Ramachandran, V., Suzuki Oscar, Lindstrom, M., Merle Lindstrom, Lindstrom Merle, Oscar Suzuki, Henson, K., Tim Wiltshire, Suzuki, O., Yingyao Zhou, Janse, C., Selina E. R. Bopp, Elizabeth A Winzeler, Spooner, M., Bopp Selina E. R., Zhou Yingyao, Brian M. Steffy, Kerstin Henson, Zhou, Y.Y., Chris Janse, Steffy, B.M., Janse Chris, Wiltshire Tim, Vandana Ramachandran, Muriel Spooner, Luzader Angelina, Angelina Luzader, Ramachandran Vandana, Spooner Muriel, Elizabeth A. Winzeler, Zhou, Y., Brian M Steffy, Andrew P Waters   +43 more
core   +1 more source

Long-term effect of uncomplicated Plasmodium berghei ANKA malaria on memory and anxiety-like behaviour in C57BL/6 mice

Parasites & Vectors, 2018
Background Cerebral malaria, the main complication of Plasmodium falciparum infection in humans, is associated with persistent neurocognitive sequels both in human disease and the murine experimental model.
Luciana Pereira de Sousa, Roberto Farina de Almeida, Flávia Lima Ribeiro-Gomes, Leonardo José de Moura Carvalho, Tadeu Mello e Souza, Diogo Onofre Gomes de Souza, Cláudio Tadeu Daniel-Ribeiro   +6 more
doaj   +1 more source

Shifts in the clinical epidemiology of severe malaria after scaling up control strategies in Mali

Frontiers in Neurology, 2022
A decrease in malaria incidence following implementation of control strategies such as use of artemisinin-based combination therapies, insecticide-impregnated nets, intermittent preventive treatment during pregnancy and seasonal malaria chemoprevention ...
Drissa Coulibaly, Abdoulaye K. Kone, Bourama Kane, Bouréima Guindo, Bourama Tangara, Mody Sissoko, Fayçal Maiga, Karim Traore, Aichatou Diawara, Amidou Traore, Ali Thera, Mahamadou S. Sissoko, Ogobara K. Doumbo, Mark A. Travassos, Mahamadou A. Thera   +14 more
doaj   +1 more source