Results 61 to 70 of about 1,645,602 (269)

The Ins and Outs of Cerebral Malaria Pathogenesis: Immunopathology, Extracellular Vesicles, Immunometabolism, and Trained Immunity

Frontiers in Immunology, 2019
Complications from malaria parasite infections still cost the lives of close to half a million people every year. The most severe is cerebral malaria (CM). Employing murine models of CM, autopsy results, in vitro experiments, neuroimaging and microscopic
F. Sierro, G. Grau
semanticscholar   +1 more source

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. [PDF]

, 2011
BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation.
Amanda Leach, Bejon, P, Walter Otieno, Kabore, W, Solange Soulanoudjingar, Njuguna, Patricia, Daniel Ansong, Kwaku Asante, Sacarlal, J, Soulanoudjingar, Solange, Ansong, D, Greenwood, Brian, Leach, Amanda, Samwel Gesase, Gesase, Samwel, Schellenberg, D, Patricia Njuguna, Bejon, Philip, Evans, Jennifer, Greenwood, B, Ansong, Daniel, Asante, KP, Clinical Trials Partnership Committee, null null, Mary J Hamel, Leach, A, Hamel, Mary J, Salim, N, Jennifer Evans, Jahit Sacarlal, Sacarlal, Jahit, Njuguna, P, Kwaku Poku Asante, Schellenberg, David, Kamthunzi, P, Gesase, S, Kevin Marsh, Asante, Kwaku Poku, Hamel, MJ, Evans, J, Portia Kamthunzi, Vekemans, J, Brian Greenwood, Vekemans, Johan, Philip Bejon, Kamthunzi, Portia, Marsh, K, Otieno, Walter, David Schellenberg, Nahya Salim, William Kabore, Otieno, W, Kabore, William, Salim, Nahya, Soulanoudjingar, S, Marsh, Kevin, Johan Vekemans   +56 more
core   +1 more source

Long-term effect of uncomplicated Plasmodium berghei ANKA malaria on memory and anxiety-like behaviour in C57BL/6 mice

Parasites & Vectors, 2018
Background Cerebral malaria, the main complication of Plasmodium falciparum infection in humans, is associated with persistent neurocognitive sequels both in human disease and the murine experimental model.
Luciana Pereira de Sousa, Roberto Farina de Almeida, Flávia Lima Ribeiro-Gomes, Leonardo José de Moura Carvalho, Tadeu Mello e Souza, Diogo Onofre Gomes de Souza, Cláudio Tadeu Daniel-Ribeiro   +6 more
doaj   +1 more source

Elevated plasma von Willebrand factor and propeptide levels in Malawian children with malaria. [PDF]

PLoS ONE, 2011
In spite of the significant mortality associated with Plasmodium falciparum infection, the mechanisms underlying severe disease remain poorly understood.
Happy T Phiri, Daniel J Bridges, Simon J Glover, Jan A van Mourik, Bas de Laat, Bridon M'baya, Terrie E Taylor, Karl B Seydel, Malcolm E Molyneux, E Brian Faragher, Alister G Craig, James E G Bunn   +11 more
doaj   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

The Economic Costs of Malaria in Children in three Sub-Saharan Countries: Ghana, Tanzania and Kenya. [PDF]

, 2013
Malaria causes significant mortality and morbidity in sub-Saharan Africa (SSA), especially among children less than five years of age (U5 children).
Sicuri, E, Constenla, Dagna, Dagna Constenla, Elisa Sicuri, Sicuri, Elisa, Vieta, Ana, Constenla, D, Christophe Sauboin, Lindner, Leandro, Vieta, A, Ana Vieta, Lindner, L, Sauboin, C, Sauboin, Christophe, Leandro Lindner   +14 more
core   +1 more source

Shifts in the clinical epidemiology of severe malaria after scaling up control strategies in Mali

Frontiers in Neurology, 2022
A decrease in malaria incidence following implementation of control strategies such as use of artemisinin-based combination therapies, insecticide-impregnated nets, intermittent preventive treatment during pregnancy and seasonal malaria chemoprevention ...
Drissa Coulibaly, Abdoulaye K. Kone, Bourama Kane, Bouréima Guindo, Bourama Tangara, Mody Sissoko, Fayçal Maiga, Karim Traore, Aichatou Diawara, Amidou Traore, Ali Thera, Mahamadou S. Sissoko, Ogobara K. Doumbo, Mark A. Travassos, Mahamadou A. Thera   +14 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Cerebral malaria in pregnancy

Journal of Obstetrics and Gynaecology, 2006
Each year approximately 300 million people are affected by malaria with over 1 million deaths in Africa Asia Oceania and South America attributable to malaria. Malaria is the most important of the parasitic diseases of human beings especially for those people living in sub-Saharan Africa where about 90%of deaths from malaria occur.
M A, Okunlola, A L, Akinwuntan, F A, Fehintola   +2 more
openaire   +2 more sources

Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-γ as contributing to enhanced malaria surviva [PDF]

, 2010
The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have used a mouse model to detect genes involved in the resistance or susceptibility to Plasmodium ...
Winzeler, E.A., Wiltshire, T., Selina E R Bopp, Waters Andrew P., Andrew P. Waters, Luzader, A., Bopp, S.E.R., Waters, A.P., Steffy Brian M., Henson Kerstin, Winzeler Elizabeth A., Ramachandran, V., Suzuki Oscar, Lindstrom, M., Merle Lindstrom, Lindstrom Merle, Oscar Suzuki, Henson, K., Tim Wiltshire, Suzuki, O., Yingyao Zhou, Janse, C., Selina E. R. Bopp, Elizabeth A Winzeler, Spooner, M., Bopp Selina E. R., Zhou Yingyao, Brian M. Steffy, Kerstin Henson, Zhou, Y.Y., Chris Janse, Steffy, B.M., Janse Chris, Wiltshire Tim, Vandana Ramachandran, Muriel Spooner, Luzader Angelina, Angelina Luzader, Ramachandran Vandana, Spooner Muriel, Elizabeth A. Winzeler, Zhou, Y., Brian M Steffy, Andrew P Waters   +43 more
core   +2 more sources