Results 61 to 70 of about 28,910 (233)
A two‐pronged screen of small molecules – (1) on recombinant kinin receptor and (2) through topical application – identifies kinin receptor antagonists, feeding behavior modulators, and new mosquitocidal molecules. Abstract BACKGROUND Aedes aegypti and Culex quinquefasciatus mosquitoes are primary vectors for numerous human and animal pathogens and ...
Bianca M. Henriques‐Santos +1 more
wiley +1 more source
Heritability of malaria in Africa [PDF]
Background While many individual genes have been identified that confer protection against malaria, the overall impact of host genetics on malarial risk remains unknown.
Williams, Thomas N. +22 more
core +1 more source
Background Interleukin-12 (IL-12), a heterodimeric cytokine composed of p35 and p40 subunits, has been thought to play an important role in the pathogenesis of malaria. The IL-12p40 subunit is encoded by the IL12B gene.
Tsuchiya Naoyuki +5 more
doaj +1 more source
Angiotensin II Moderately Decreases Plasmodium Infection and Experimental Cerebral Malaria in Mice. [PDF]
Angiotensin II, a peptide hormone that regulates blood pressure, has been proposed as a protective factor against cerebral malaria based on a genetic analysis.
Julio Gallego-Delgado +7 more
doaj +1 more source
ABSTRACT Double‐stranded DNA coming from, for example, viruses, bacteria, or apoptotic cells is recognized by the cGAS‐STING signaling pathway comprising the cyclic GMP‐AMP synthase (cGAS) and the stimulator of interferon genes (STING) receptors. The pathway induces type I interferon response and activates transcription of interferon‐stimulated genes ...
András Harazin +9 more
wiley +1 more source
Maternal Malaria and Gravidity Interact to Modify Infant Susceptibility to Malaria [PDF]
Background In endemic areas, placental malaria due to Plasmodium falciparum is most frequent and severe in first-time mothers, and increases the risk of infant mortality in their offspring.
Theonest K Mutabingwa +20 more
core +1 more source
Background In developing countries where Plasmodium falciparum malaria is endemic, viral encephalitis and cerebral malaria are found in the same population, and parasitemia with Plasmodium falciparum is common in asymptomatic children.
Atmakuri RM +3 more
doaj +1 more source
Is there a role for bradykinin in cerebral malaria pathogenesis?
Malaria is a parasitic disease of global health significance and a leading cause of death in children living in endemic regions. Although various Plasmodium species are responsible for the disease, Plasmodium falciparum infection accounts for most severe
Alessandro de Sa Pinheiro +4 more
doaj +1 more source
Invasive Bacterial Co-infection in African Children with Plasmodium falciparum Malaria: A Systematic Review. [PDF]
Severe malaria remains a major cause of pediatric hospital admission across Africa. Invasive bacterial infection (IBI) is a recognized complication of Plasmodium falciparum malaria, resulting in a substantially worse outcome.
Maitland, Kathryn +4 more
core +1 more source
Objective: To know whether the effect of interferon-induced protein with tetratricopeptide repeats (IFIT) 1 polymorphism influences the susceptibility of cerebral malaria outcome.
Saw Thu Wah +5 more
doaj +1 more source

