Results 51 to 60 of about 28,910 (233)

Cerebral Malaria

Brain Pathology, 1997
Malaria infection of the Central Nervous System (CNS) can cause a severe neurological syndrome termed Cerebral Malaria (CM). The central neuropathological feature of CM is the preferential sequestration of parasitised red blood cells (PRBC) in the cerebral microvasculature.
openaire   +3 more sources

Evaluating predictive values of umbilical cord arterial lactate for adverse newborn outcomes among term‐births in northern Uganda: A cross sectional analytical study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 408-420, April 2025.
Abstract Objective Birth asphyxia is one of the leading causes of death for neonates worldwide. Lack of an objective cost effective test to predict poor newborn outcomes at birth affects the ability to respond appropriately. This study determined predictive values of umbilical cord arterial lactate in relation to adverse neonatal outcomes. Methods This
Elizabeth Ayebare, James K. Tumwine, Jolly Nankunda, Anna Hjelmstedt, Wibke Jonas, Grace Ndeezi, Nicola Orsini, Claudia Hanson   +7 more
wiley   +1 more source

Gene expression profiling in blood from cerebral malaria patients and mild malaria patients living in Senegal

BMC Medical Genomics, 2019
Background Plasmodium falciparum malaria remains a major health problem in Africa. The mechanisms of pathogenesis are not fully understood. Transcriptomic studies may provide new insights into molecular pathways involved in the severe form of the disease.
Alassane Thiam, Michel Sanka, Rokhaya Ndiaye Diallo, Magali Torres, Babacar Mbengue, Nicolas Fernandez Nunez, Fatou Thiam, Gora Diop, Geneviève Victorero, Catherine Nguyen, Alioune Dieye, Pascal Rihet   +11 more
doaj   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, EarlyView.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement. [PDF]

, 2012
In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein 2 (PfHRP2) is released by mature sequestered
Pan-Ngum Wirichada, George Mtove (124816), Gesase Samwel, Woodrow, Charles, Saiwaew, Somporn, Mwanga-Amumpaire Juliet, Fanello, CI, Kathryn Maitland, Ermelinda Gomes, Sarah Joseph (140503), White, Lisa, Nicholas J. White (35779), Ilse C E Hendriksen, Arjen M Dondorp, Gomes, Ermelinda, Samwel Gesase, Charles Woodrow, Sue J. Lee (140486), Rasaq Olaosebikan, Kesinee Chotivanich (140505), Fanello, Caterina I, Nicholas J White, Hendriksen Ilse C. E., White Nicholas J., von Seidlein Lorenz, Tshefu, Antoinette K, Antoinette K. Tshefu (140488), Sarah Joseph, von Seidlein, Lorenz, Antoinette K Tshefu, Lee, Sue, Silamut, Kamolrat, Tshefu Antoinette K., Woodrow, C, Corine Karema (140493), Ilse C. E. Hendriksen (140479), Mwanga-Amumpaire, J, Day Nicholas P. J., White Lisa J., White, Nicholas J, Caterina I. Fanello (140506), Maitland, K, Lee Sue J., Nicholas P J Day, Dondorp, Arjen M, Kamolrat Silamut (140501), Maitland Kathryn, Woodrow Charles, Dondorp, Adrianus, Arjen M. Dondorp (140509), Reyburn, Hugh, Day, Nicholas P J, Tshefu, AK, Day, Nicholas, Sue J Lee, Corine Karema, Juliet Mwanga-Amumpaire (140482), White, NJ, Lorenz von Seidlein (45473), Amos Ben, White, Lisa J, Lisa J White, Maitland, Kathryn, Amos, Ben, Somporn Saiwaew (140495), Silamut Kamolrat, Olaosebikan, Rasaq, Gomes, E, Lorenz von Seidlein, Pan-Ngum, W, Mtove, G, Samwel Gesase (140499), Hendriksen, ICE, Wirichada Pan-Ngum (2583205), Nicholas P. J. Day (35781), George Mtove, Joseph, Sarah, Gesase, Samwel, Hendriksen, IC, Chotivanich Kesinee, Saiwaew, S, Lisa J. White (101780), Hendriksen, Ilse C E, von Seidlein, L, Fanello Caterina I., Hugh Reyburn (45198), Reyburn Hugh, Juliet Mwanga-Amumpaire, Charles Woodrow (140489), Hendriksen, AM, Ben Amos (140491), Lee, Sue J, Gomes Ermelinda, Chotivanich, Kesinee, Wirichada Pan-Ngum, White, Nicholas, White, LJ, Ben Amos, Dondorp, AM, Gesase, S, Pan-Ngum, Wirichada, Mwanga-Amumpaire, Juliet, Amos, B, Karema, C, Day, NP, Joseph, S, Day, NPJ, Karema Corine, Saiwaew Somporn, Joseph Sarah, Karema, Corine, Lee, SJ, Chotivanich, K, Ermelinda Gomes (140497), Somporn Saiwaew, Kamolrat Silamut, Reyburn, H, Hugh Reyburn, Kesinee Chotivanich, Rasaq Olaosebikan (130780), Olaosebikan Rasaq, Kathryn Maitland (21356), Dondorp Arjen M., Silamut, K, Mtove George, Olaosebikan, R, Mtove, George, Caterina I Fanello   +127 more
core   +1 more source

Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriers. [PDF]

PLoS ONE, 2014
The mechanisms underlying the heterogeneity of clinical malaria remain largely unknown. We hypothesized that differential gene expression contributes to phenotypic variation of parasites which results in a specific interaction with the host, leading to ...
Talleh Almelli, Grégory Nuel, Emmanuel Bischoff, Agnès Aubouy, Mohamed Elati, Christian William Wang, Marie-Agnès Dillies, Jean-Yves Coppée, Georges Nko Ayissi, Leonardo Kishi Basco, Christophe Rogier, Nicaise Tuikue Ndam, Philippe Deloron, Rachida Tahar   +13 more
doaj   +1 more source

Uncomplicated Malaria in Infancy and Neurodevelopment at 1 and 6 Years: Evidence From the MiPPAD Birth Cohort Study of Benin

Tropical Medicine &International Health, EarlyView.
ABSTRACT In malaria‐endemic regions, repeated episodes of uncomplicated malaria during infancy are common; however, their associations with neurodevelopment remain unclear. We examined relationships between malaria frequency in infancy and neurodevelopmental outcomes in early and middle childhood, using data from the APEC birth cohort nested within the
Juthathip Khongpetch, Michael J. Boivin, Michel Cot, Jacqueline Milet, Roméo Zoumenou, Christophe Fermanian, Achille Massougbodji, Florence Bodeau‐Livinec   +7 more
wiley   +1 more source

Photobiomodulation restores blood–brain barrier integrity after hypoxia via endothelial von Willebrand factor modulation in a humanised tricellular transwell model

The Journal of Physiology, EarlyView.
Abstract figure legend Photobiomodulation restores blood–brain barrier (BBB) integrity following hypoxic stress. A multicellular human BBB model comprising brain microvascular endothelial cells, astrocytes and pericytes was established in a transwell system and subjected to acute hypoxia.
Mirriam Domocos, Denis E. Bragin, Nagesh C. Shanbhag, Luise Schlotterose, Mootaz M. Salman   +4 more
wiley   +1 more source

Hypertension and maternal-fetal conflict during placental malaria. [PDF]

, 2006
BACKGROUND: Malaria and hypertension are major causes of maternal mortality in tropical countries, especially during first pregnancies, but evidence for a relationship between these syndromes is contradictory.
Theonest K Mutabingwa, Sally Edmonds, Duffy Patrick E, Michal Fried, Mutabingwa, TK, Edmonds, S, Patrick E Duffy, Mutabingwa Theonest K, Muehlenbachs, A, Muehlenbachs Atis, Duffy, PE, Fried Michal, Mutabingwa, Theonest K, Fried, Michal, Muehlenbachs, Atis, Edmonds Sally, Duffy, Patrick E, Atis Muehlenbachs, Edmonds, Sally, Fried, M   +19 more
core   +1 more source