Results 31 to 40 of about 1,645,602 (269)

Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia [PDF]

, 2006
The Plasmodium falciparum variant erythrocyte surface antigens known as PfEMP1, encoded by the var gene family, are thought to play a crucial role in malaria pathogenesis because they mediate adhesion to host cells and immuno-modulation.
Thera, Mahamadou A, Stone, Graham N, Koné, Abdoulaye K, Challis, Richard J, Lyke, Kirsten E, Rowe, J Alexandra; id_orcid, Kyriacou, Helen M, Raza, Ahmed, Doumbo, Ogobara K, Plowe, Christopher V   +9 more
core   +1 more source

Cerebral Malaria in a Patient with Recent Travel to the Congo Presenting with Delirium: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2020
Introduction: Cerebral malaria, a syndrome of altered consciousness, is a rare and severe neurologic complication resulting from Plasmodium falciparum. 1 Historically, cerebral malaria has been seen more frequently in children rather than adults.
Megan T. Roberson, Austin T. Smith
doaj   +1 more source

Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?

Frontiers in Molecular Biosciences, 2022
Plasmodium falciparum is responsible for the most severe and deadliest human malaria infection. The most serious complication of this infection is cerebral malaria.
Michael Oluwatoyin Daniyan, Funmilola Adesodun Fisusi, Olufunso Bayo Adeoye   +2 more
doaj   +1 more source

Locally up-regulated lymphotoxin a, not systemic tumor necrosis factor a, is the principle mediator of murine cerebral malaria [PDF]

, 2002
Cerebral malaria (CM) causes death in children and nonimmune adults. TNF-{alpha} has been thought to play a key role in the development of CM. In contrast, the role of the related cyto-kine lymphotoxin {alpha} (LT{alpha}) in CM has been overlooked.
Sanjeet Sawhney, Mynott, T.L., Kaye, PM, De Souza, J Brian, Bickle, Quentin D, Kaye, P.M., Engwerda, C.R., Sawhney, Sanjeet, Engwerda, CR, Tracey L. Mynott, Paul M. Kaye, Christian R. Engwerda, Bickle, Q.D., Sawhney, S, Bickle, QD, Mynott, Tracey L, De Souza, JB, Mynott, TL, Engwerda, Christian R, Sawhney, S., J. Brian De Souza, Quentin D. Bickle, Kaye, Paul M, De Souza, J.B.   +23 more
core   +1 more source

Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria.

PLoS Pathogens, 2016
Plasmodium falciparum infection causes a wide spectrum of diseases, including cerebral malaria, a potentially life-threatening encephalopathy. Vasculopathy is thought to contribute to cerebral malaria pathogenesis. The vasoactive compound endothelin-1, a
Brandi D Freeman, Yuri C Martins, Oscar B Akide-Ndunge, Fernando P Bruno, Hua Wang, Herbert B Tanowitz, David C Spray, Mahalia S Desruisseaux   +7 more
doaj   +1 more source

Association of cerebral malaria and TNF-α levels: a systematic review

BMC Infectious Diseases, 2020
Background Cerebral malaria is the most severe form of infection with Plasmodium falciparum characterized by a highly inflammatory response. This systematic review aimed to investigate the association between TNF-α levels and cerebral malaria.
L. Leão, B. Puty, M. Dolabela, M. Póvoa, Yago Gecy de Sousa Né, Luciana Guimarães Eiró, N. Fagundes, L. Maia, R. R. Lima   +8 more
semanticscholar   +1 more source

Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report. [PDF]

, 2010
BACKGROUND: Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly recognized, human pathogen. For the first time, post-mortem findings from a fatal case of knowlesi malaria are reported here.
Hiu, Jessie, Mohammad, Zulkarnaen, Patricia Chandran, Zulkarnaen Mohammad, Adem, P, Paul C Divis, Singh Balbir, Lucas, S.B., Patricia, Adem, Balbir, Singh, Singh, Balbir, Janet Cox-Singh, Singh, B, Balbir Singh, Janet, Cox-Singh, Divis, P.C., Divis Paul C, Kum T, Wong, Chandran, Patricia, Wong Kum T, Paul C, Divis, Sanjeev, Krishna, Wong, Kum T., Zaki, Sherif R., Krishna, S., Chandran Patricia, Kum T Wong, Sanjeev Krishna, Jessie Hiu, Zaki Sherif R, Patricia, Chandran, Singh, B., Sherif R Zaki, Jessie, Hiu, Hiu, J, Chandran, P., Wong, K.T., Wong, KT, Cox-Singh, J, Adem, Patricia, Zulkarnaen, M, Divis, Paul C., Zulkarnaen, Mohammad, Sherif R, Zaki, Lucas Sebastian B, Cox-Singh Janet, Krishna Sanjeev, Mohammad Zulkarnaen, Lucas, Sebastian B., Sebastian B Lucas, Zaki, SR, Cox Singh, Janet, Cox-Singh, J., Krishna, S, Adem Patricia, Chandran, P, Krishna, Sanjeev, Adem, P., Hiu Jessie, Zulkarnaen, M., Patricia Adem, Zaki, S.R., Divis, PC, Lucas, SB, Hiu, J., Sebastian B, Lucas   +65 more
core   +1 more source

Surviving cerebral malaria [PDF]

Neurology, 2018
A 48-year-old man from Minnesota declined malaria prophylaxis before hunting in South Africa. Ten days after his return, he developed body aches, confusion progressing to flaccid unresponsiveness, acute liver and renal failure, shock, and thrombocytopenia. On blood smear, Plasmodium falciparum burden was 24% and fell rapidly after aggressive management.
Eelco F M, Wijdicks, John G, Park
openaire   +2 more sources

Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda. [PDF]

, 2009
BACKGROUND: In endemic areas, falciparum malaria remains the leading cause of seizures in children presenting to emergency departments. In addition, seizures in malaria have been shown to increase morbidity and mortality in these patients. The management
Staedke Sarah G, Rosenthal, Philip J, Sarah G Staedke, Staedke, Sarah G, Byarugaba Justus, Arthur Mpimbaza, Mpimbaza Arthur, Philip J Rosenthal, Justus Byarugaba, Ndeezi, Grace, Rosenthal Philip J, Mpimbaza, Arthur, Ndeezi Grace, Grace Ndeezi, Byarugaba, Justus   +14 more
core   +1 more source

A HOSPITAL-BASED RETROSPECTIVE COMPARATIVE STUDY OF COMPLICATIONS, OUTCOMES, CLINICAL AND LABORATORY PARAMETERS OF MALARIA WITH AND WITHOUT NEUROLOGICAL INVOLVEMENT

Mediterranean Journal of Hematology and Infectious Diseases, 2017
Background & Objectives: Classically associated with Plasmodium falciparum, neurological complications in severe malaria is associated with increased morbidity and mortality.
Sohaib Ahmad, Nadia Shirazi, Nowneet Kumar Bhat, Minakshi Dhar, Garima Mittal, Manish Mittal, Nidhi Kaeley, Manoj Kumar   +7 more
doaj   +1 more source