Results 21 to 30 of about 28,910 (233)

Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria.

PLoS Pathogens, 2016
Plasmodium falciparum infection causes a wide spectrum of diseases, including cerebral malaria, a potentially life-threatening encephalopathy. Vasculopathy is thought to contribute to cerebral malaria pathogenesis. The vasoactive compound endothelin-1, a
Brandi D Freeman, Yuri C Martins, Oscar B Akide-Ndunge, Fernando P Bruno, Hua Wang, Herbert B Tanowitz, David C Spray, Mahalia S Desruisseaux   +7 more
doaj   +1 more source

Locally up-regulated lymphotoxin a, not systemic tumor necrosis factor a, is the principle mediator of murine cerebral malaria [PDF]

, 2002
Cerebral malaria (CM) causes death in children and nonimmune adults. TNF-{alpha} has been thought to play a key role in the development of CM. In contrast, the role of the related cyto-kine lymphotoxin {alpha} (LT{alpha}) in CM has been overlooked.
Sanjeet Sawhney, Mynott, T.L., Kaye, PM, De Souza, J Brian, Bickle, Quentin D, Kaye, P.M., Engwerda, C.R., Sawhney, Sanjeet, Engwerda, CR, Tracey L. Mynott, Paul M. Kaye, Christian R. Engwerda, Bickle, Q.D., Sawhney, S, Bickle, QD, Mynott, Tracey L, De Souza, JB, Mynott, TL, Engwerda, Christian R, Sawhney, S., J. Brian De Souza, Quentin D. Bickle, Kaye, Paul M, De Souza, J.B.   +23 more
core   +1 more source

Surviving cerebral malaria [PDF]

Neurology, 2018
A 48-year-old man from Minnesota declined malaria prophylaxis before hunting in South Africa. Ten days after his return, he developed body aches, confusion progressing to flaccid unresponsiveness, acute liver and renal failure, shock, and thrombocytopenia. On blood smear, Plasmodium falciparum burden was 24% and fell rapidly after aggressive management.
Eelco F M, Wijdicks, John G, Park
openaire   +2 more sources

Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda. [PDF]

, 2009
BACKGROUND: In endemic areas, falciparum malaria remains the leading cause of seizures in children presenting to emergency departments. In addition, seizures in malaria have been shown to increase morbidity and mortality in these patients. The management
Staedke Sarah G, Rosenthal, Philip J, Sarah G Staedke, Staedke, Sarah G, Byarugaba Justus, Arthur Mpimbaza, Mpimbaza Arthur, Philip J Rosenthal, Justus Byarugaba, Ndeezi, Grace, Rosenthal Philip J, Mpimbaza, Arthur, Ndeezi Grace, Grace Ndeezi, Byarugaba, Justus   +14 more
core   +1 more source

A HOSPITAL-BASED RETROSPECTIVE COMPARATIVE STUDY OF COMPLICATIONS, OUTCOMES, CLINICAL AND LABORATORY PARAMETERS OF MALARIA WITH AND WITHOUT NEUROLOGICAL INVOLVEMENT

Mediterranean Journal of Hematology and Infectious Diseases, 2017
Background & Objectives: Classically associated with Plasmodium falciparum, neurological complications in severe malaria is associated with increased morbidity and mortality.
Sohaib Ahmad, Nadia Shirazi, Nowneet Kumar Bhat, Minakshi Dhar, Garima Mittal, Manish Mittal, Nidhi Kaeley, Manoj Kumar   +7 more
doaj   +1 more source

Chorismate synthase mediates cerebral malaria pathogenesis by eliciting salicylic acid-dependent autophagy response in parasite

Biology Open, 2020
Cerebral malaria caused by Plasmodium falciparum is the severest form of the disease resulting in the morbidity of a huge number of people worldwide. Development of effective curatives is essential in order to overcome the fatality of cerebral malaria ...
Malabika Chakrabarti, Deepika Kannan, Akshay Munjal, Hadi Hasan Choudhary, Satish Mishra, Shailja Singh   +5 more
doaj   +1 more source

Grading fluorescein angiograms in malarial retinopathy [PDF]

, 2015
This work was funded by The Wellcome Trust (IJCM, SPH, NAVB, MEM, DP, SoL: Grant No. 092668/Z/10/Z; Core Grant No. 084679/Z/08/Z).Background: Malarial retinopathy is an important finding in Plasmodium falciparum cerebral malaria, since it strengthens ...
Malcolm E. Molyneux, Molyneux, Malcolm E, Harding, Simon P, Maude, Richard J., Dhillon, Baljean, Ian J. C. MacCormick, Beare, Nicholas A. V., Beare, Nicholas A V, Simon Glover, Leach, Sophie, Lewallen, Susan, MacCormick, Ian J C, Molyneux, Malcolm E., Nicholas A. V. Beare, David Parry, Sophie Leach, Susan Lewallen, Glover, Simon, Simon P. Harding, MacCormick, Ian JC, Shyamanga Borooah, Borooah, Shyamanga, Harding, Simon P., Richard J. Maude, Parry, David, MacCormick, Ian J. C., Baljean Dhillon, Maude, Richard J, Beare, Nicholas AV, Glover, Simon James   +29 more
core   +1 more source

Severe falciparum malaria in Gabonese children: clinical and laboratory features. [PDF]

, 2005
BACKGROUND: Malaria continues to claim one to two million lives a year, mainly those of children in sub-Saharan Africa. Reduction in mortality depends, in part, on improving the quality of hospital care, the training of healthcare workers and ...
Mboza, Béatrice, Planche, Timothy, Mboza, B, Jarvis, J, Mboza Béatrice, Eric Kendjo, Kendjo Eric, Arnaud Dzeing-Ella, Mbounja, Monique, Jarvis Joseph, Kombila, Maryvonne, Planche, T, Maryvonne Kombila, Tchoua, R, Tchoua, Rose, Monique Mbounja, Peter G Kremsner, Nze Obiang, PC, Kombila, M, Ngou-Milama Edouard, Planche Timothy, Ulrich Muller-Roemer, Sanjeev Krishna, Ngou-Milama, Edouard, Pascal C Nze Obiang, Kombila Maryvonne, Timothy Planche, Béatrice Mboza, Kendjo, E, Rose Tchoua, Nze Obiang, Pascal C, Dzeing-Ella Arnaud, Kendjo, Eric, Jarvis, Joseph, Nze Obiang Pascal C, Kremsner, Peter G, Muller-Roemer Ulrich, Ngou-Milama, E, Krishna Sanjeev, Tchoua Rose, Muller-Roemer, U, Kremsner, PG, Krishna, S, Edouard Ngou-Milama, Dzeing-Ella, Arnaud, Kremsner Peter G, Krishna, Sanjeev, Mbounja, M, Muller-Roemer, Ulrich, Dzeing-Ella, A, Joseph Jarvis, Mbounja Monique   +51 more
core   +1 more source

BIOMOLECULAR ASPECTS AND UPDATE ON TREATMENT OF CEREBRAL MALARIA

Malang Neurology Journal, 2016
Malaria is still becoming a health problem in the world and in Indonesia. Cerebral malaria is one of many features of severe and life threatening malaria. Many hypotheses underlying the pathophysiology of cerebral malaria have been disclosed, but the one
Machlusil Husna, Bowo Hery Prasetyo
doaj   +1 more source

Human immunodeficiency virus infection and cerebral malaria in children in Uganda: a case-control study

BMC Pediatrics, 2011
Background Human immunodeficiency virus (HIV)-1 infection increases the burden of malaria by increasing susceptibility to infection and decreasing the response to malarial treatment.
Byarugaba Justus, Musoke Philippa, Imani Peace D, Tumwine James K   +3 more
doaj   +1 more source