Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria [PDF]
, 2009 Background Severe and cerebral malaria are associated with endothelial activation. Angiopoietin-1 (ANG-1) and angiopoietin-2 (ANG-2) are major regulators of endothelial activation and integrity.
Liles W Conrad +21 more
core +1 more source
Admission Diagnosis of Cerebral Malaria in Adults in an Endemic Area of Tanzania:Implications and Clinical Description [PDF]
, 2003 Cerebralmalariais commonly diagnosed in adults in endemic areas in Africa, both in hospitals and in the community. This presents a paradox inconsistent with the epidemiological understanding that the development of immunity during childhood confers ...
Liyombo, E +10 more
core +1 more source
Association of ADAMTS13 polymorphism with cerebral malaria
Malaria Journal, 2011 Background Cerebral malaria is one of the most severe manifestations of Plasmodium falciparum malaria. The sequestration of parasitized red blood cells (PRBCs) to brain microvascular endothelium has been shown to contribute to the pathophysiology of ...
Kraisin Sirima +7 more
doaj +1 more source
Cytokine response during non-cerebral and cerebral malaria: evidence of a failure to control inflammation as a cause of death in African adults [PDF]
PeerJ, 2016 Background. With 214 million cases and 438,000 deaths in 2015, malaria remains one of the deadliest infectious diseases in tropical countries. Several species of the protozoan Plasmodium cause malaria.
Yakhya Dieye +8 more
doaj +2 more sources
Host Blood Gene Signatures Can Detect the Progression to Severe and Cerebral Malaria
Frontiers in Cellular and Infection Microbiology, 2021 Malaria is a major international public health problem that affects millions of patients worldwide especially in sub-Saharan Africa. Although many tests have been developed to diagnose malaria infections, we still lack reliable diagnostic biomarkers for ...
Mohamed Omar +5 more
doaj +1 more source
Clinical Infectious Diseases, 2020 Background Cerebral malaria is a common presentation of severe Plasmodium falciparum infection and remains an important cause of death in the tropics. Key aspects of its pathogenesis are still incompletely understood, but severe brain swelling identified
P. Sahu +20 more
semanticscholar +1 more source
Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. [PDF]
, 2009 BACKGROUND: Limited tools exist to identify which individuals infected with Plasmodium falciparum are at risk of developing serious complications such as cerebral malaria (CM). The objective of this study was to assess serum biomarkers that differentiate
Hawkes, Michael +38 more
core +1 more source
BMC Research Notes, 2009 Background Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine implicated in the pathogenesis of a number of human diseases including inflammatory neurological diseases.
Udhayakumar Venkatachalam +7 more
doaj +1 more source
Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children. [PDF]
, 2010 BACKGROUND: Cerebral malaria (CM) represents a severe outcome of the Plasmodium falciparum infection. Recent genetic studies have correlated human genes with severe malaria susceptibility, but there is little data on genetic variants that increase the ...
Sambo, Maria Rosário +39 more
core +1 more source
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Malaria is a deadly disease affecting hundreds of millions of people. Cerebral malaria is a type of severe disease with a high mortality rate.
Xiao He +16 more
semanticscholar +1 more source