Results 1 to 10 of about 24,919 (139)
NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients [PDF]
PeerJ, 2018 Background Host factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 ...
Alassane Thiam +12 more
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BIOMARKERS AND PROGNOSTIC SCORING IN CEREBRAL MALARIA
Malang Neurology Journal, 2022 Malaria remains a public health concern and remain the deadliest in infectious disease in the world. Cerebral malaria is a particularly severe complication of this disease and associated with high mortality.
Orlando Pikatan +3 more
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Cerebral malaria and the story of Quinine and the Fever Trees
Advances in Clinical Neuroscience & Rehabilitation, 2020 Cinchona bark was first recorded as a cure for malaria by the Spanish in Peru around 1630. A Spanish missionary allegedly learned of the treatment from the Indian natives.
JMS Pearce
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Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. [PDF]
PLoS Pathogens, 2012 Cerebral malaria is a major, life-threatening complication of Plasmodium falciparum malaria, and has very high mortality rate. In murine malaria models, natural killer (NK) cell responses have been shown to play a crucial role in the pathogenesis of ...
Kouyuki Hirayasu +13 more
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Association of ADAMTS13 polymorphism with cerebral malaria
Malaria Journal, 2011 Background Cerebral malaria is one of the most severe manifestations of Plasmodium falciparum malaria. The sequestration of parasitized red blood cells (PRBCs) to brain microvascular endothelium has been shown to contribute to the pathophysiology of ...
Kraisin Sirima +7 more
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Cytokine response during non-cerebral and cerebral malaria: evidence of a failure to control inflammation as a cause of death in African adults [PDF]
PeerJ, 2016 Background. With 214 million cases and 438,000 deaths in 2015, malaria remains one of the deadliest infectious diseases in tropical countries. Several species of the protozoan Plasmodium cause malaria.
Yakhya Dieye +8 more
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Host Blood Gene Signatures Can Detect the Progression to Severe and Cerebral Malaria
Frontiers in Cellular and Infection Microbiology, 2021 Malaria is a major international public health problem that affects millions of patients worldwide especially in sub-Saharan Africa. Although many tests have been developed to diagnose malaria infections, we still lack reliable diagnostic biomarkers for ...
Mohamed Omar +5 more
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Cytokines and Chemokines in Cerebral Malaria Pathogenesis
Frontiers in Cellular and Infection Microbiology, 2017 Cerebral malaria is among the major causes of malaria-associated mortality and effective adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes involved in the development of cerebral malaria include an imbalance of
Josefine Dunst +7 more
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BMC Research Notes, 2009 Background Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine implicated in the pathogenesis of a number of human diseases including inflammatory neurological diseases.
Udhayakumar Venkatachalam +7 more
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Clinical Practice and Cases in Emergency Medicine, 2020 Introduction: Cerebral malaria, a syndrome of altered consciousness, is a rare and severe neurologic complication resulting from Plasmodium falciparum. 1 Historically, cerebral malaria has been seen more frequently in children rather than adults.
Megan T. Roberson, Austin T. Smith
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