Results 11 to 20 of about 28,922 (237)

Cerebral Malaria [PDF]

Practical Neurology, 2004
Successful management of cerebral malaria requires rapid diagnosis, initiation of appropriate antimalarial agents, and aggressive supportive care. The antimalarial used will depend on drug availability, with many of the most effective agents not routinely available in the US.
openaire   +3 more sources

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease. [PDF]

, 2009
Cerebral malaria is a life-threatening complication of malaria infection. The pathogenesis of cerebral malaria is poorly defined and progress in understanding the condition is severely hampered by the inability to study in detail, ante-mortem, the ...
KEVIN N. COUPER, Couper, Kevin N, Riley, Eleanor M, Hafalla, Julius CR, Brian De Souza, J., Hafalla, Julius C R, Couper, Kevin N., JULIUS C. R. HAFALLA, de Souza, J Brian, Riley, Eleanor M., ELEANOR M. RILEY, J. BRIAN de SOUZA   +11 more
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Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria [PDF]

, 2009
Background Severe and cerebral malaria are associated with endothelial activation. Angiopoietin-1 (ANG-1) and angiopoietin-2 (ANG-2) are major regulators of endothelial activation and integrity.
Liles W Conrad, Kain, Kevin C, Kevin C Kain, Kain Kevin C, Liles, W C, Conroy, Andrea L, Conroy Andrea L, Krudsood Srivicha, Erin I Lafferty, Srivicha Krudsood, Lafferty Erin I, Lovegrove, Fiona E, Lafferty, Erin I, Tangpukdee, Noppadon, Fiona E Lovegrove, W Conrad Liles, Tangpukdee Noppadon, Lovegrove Fiona E, Krudsood, Srivicha, Liles, W Conrad, Andrea L Conroy, Noppadon Tangpukdee   +21 more
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Admission Diagnosis of Cerebral Malaria in Adults in an Endemic Area of Tanzania:Implications and Clinical Description [PDF]

, 2003
Cerebralmalariais commonly diagnosed in adults in endemic areas in Africa, both in hospitals and in the community. This presents a paradox inconsistent with the epidemiological understanding that the development of immunity during childhood confers ...
Liyombo, E, Matuja, W, Snow, RW, Makani, J, Snow, R. W, Marsh, K, Warrell, D, Makani, Julie, Marsh, Kevin, Snow, Robert, Warrell, DA   +10 more
core   +1 more source

Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. [PDF]

, 2009
BACKGROUND: Limited tools exist to identify which individuals infected with Plasmodium falciparum are at risk of developing serious complications such as cerebral malaria (CM). The objective of this study was to assess serum biomarkers that differentiate
Hawkes, Michael, Nimerta Rajwans, Michael Hawkes, Kevin C Kain, Lafferty, Erin I., John, Chandy C, Sornchai Looareesuwan, Srivicha Krudsood, Tangpukdee, Noppadon, Lafferty, Erin I, Looareesuwan Sornchai, Fiona E Lovegrove, Krudsood, Srivicha, John Chandy C., Rajwans, Nimerta, Opoka, Robert, Noppadon Tangpukdee, Hawkes Michael, Lafferty Erin I., Lovegrove Fiona E., Kain, Kevin C, Looareesuwan, Sornchai, Lovegrove, Fiona E., Opoka Robert O., Krudsood Srivicha, Kain, Kevin C., Erin I Lafferty, Kain Kevin C., Robert O Opoka, Lovegrove, Fiona E, Rajwans Nimerta, John, Chandy C., W Conrad Liles, Liles, W. Conrad, Tangpukdee Noppadon, Liles, W Conrad, Chandy C John, Opoka, Robert O, Liles W. Conrad   +38 more
core   +1 more source

Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children. [PDF]

, 2010
BACKGROUND: Cerebral malaria (CM) represents a severe outcome of the Plasmodium falciparum infection. Recent genetic studies have correlated human genes with severe malaria susceptibility, but there is little data on genetic variants that increase the ...
Sambo, Maria Rosário, Carla Benchimol, Marques, Maria Isabel, Nuno Sepúlveda, Carlos Penha-Gonçalves, Maria Rosário Sambo, Maria Isabel Marques, Stefan Mustafa, Sepúlveda, Nuno, Sepúlveda Nuno, Gonçalves Lígia, Trovoada, Maria Jesus, Mustafa Stefan, Rute Velosa, Marques Maria Isabel, Velosa, Rute, António Coutinho, Benchimol, Carla, Vatúsia Quinhentos, Sambo Maria Rosário, Quinhentos Vatúsia, Oswald Wagner, Taane G Clark, Benchimol Carla, Penha-Gonçalves Carlos, Penha-Gonçalves, Carlos, Gonçalves, Lígia, Mustafa, Stefan, Coutinho, António, Maria Jesus Trovoada, Coutinho António, Clark Taane G., Lígia Gonçalves, Trovoada Maria Jesus, Quinhentos, Vatúsia, Wagner, Oswald, Wagner Oswald, Taane G. Clark, Clark, Taane G, Velosa Rute   +39 more
core   +1 more source

Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report. [PDF]

, 2010
BACKGROUND: Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly recognized, human pathogen. For the first time, post-mortem findings from a fatal case of knowlesi malaria are reported here.
Hiu, Jessie, Mohammad, Zulkarnaen, Patricia Chandran, Zulkarnaen Mohammad, Adem, P, Paul C Divis, Singh Balbir, Lucas, S.B., Patricia, Adem, Balbir, Singh, Singh, Balbir, Janet Cox-Singh, Singh, B, Balbir Singh, Janet, Cox-Singh, Divis, P.C., Divis Paul C, Kum T, Wong, Chandran, Patricia, Wong Kum T, Paul C, Divis, Sanjeev, Krishna, Wong, Kum T., Zaki, Sherif R., Krishna, S., Chandran Patricia, Kum T Wong, Sanjeev Krishna, Jessie Hiu, Zaki Sherif R, Patricia, Chandran, Singh, B., Sherif R Zaki, Jessie, Hiu, Hiu, J, Chandran, P., Wong, K.T., Wong, KT, Cox-Singh, J, Adem, Patricia, Zulkarnaen, M, Divis, Paul C., Zulkarnaen, Mohammad, Sherif R, Zaki, Lucas Sebastian B, Cox-Singh Janet, Krishna Sanjeev, Mohammad Zulkarnaen, Lucas, Sebastian B., Sebastian B Lucas, Zaki, SR, Cox Singh, Janet, Cox-Singh, J., Krishna, S, Adem Patricia, Chandran, P, Krishna, Sanjeev, Adem, P., Hiu Jessie, Zulkarnaen, M., Patricia Adem, Zaki, S.R., Divis, PC, Lucas, SB, Hiu, J., Sebastian B, Lucas   +65 more
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Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?

Frontiers in Molecular Biosciences, 2022
Plasmodium falciparum is responsible for the most severe and deadliest human malaria infection. The most serious complication of this infection is cerebral malaria.
Michael Oluwatoyin Daniyan, Funmilola Adesodun Fisusi, Olufunso Bayo Adeoye   +2 more
doaj   +1 more source

Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria.

PLoS Pathogens, 2016
Plasmodium falciparum infection causes a wide spectrum of diseases, including cerebral malaria, a potentially life-threatening encephalopathy. Vasculopathy is thought to contribute to cerebral malaria pathogenesis. The vasoactive compound endothelin-1, a
Brandi D Freeman, Yuri C Martins, Oscar B Akide-Ndunge, Fernando P Bruno, Hua Wang, Herbert B Tanowitz, David C Spray, Mahalia S Desruisseaux   +7 more
doaj   +1 more source

Locally up-regulated lymphotoxin a, not systemic tumor necrosis factor a, is the principle mediator of murine cerebral malaria [PDF]

, 2002
Cerebral malaria (CM) causes death in children and nonimmune adults. TNF-{alpha} has been thought to play a key role in the development of CM. In contrast, the role of the related cyto-kine lymphotoxin {alpha} (LT{alpha}) in CM has been overlooked.
Sanjeet Sawhney, Mynott, T.L., Kaye, PM, De Souza, J Brian, Bickle, Quentin D, Kaye, P.M., Engwerda, C.R., Sawhney, Sanjeet, Engwerda, CR, Tracey L. Mynott, Paul M. Kaye, Christian R. Engwerda, Bickle, Q.D., Sawhney, S, Bickle, QD, Mynott, Tracey L, De Souza, JB, Mynott, TL, Engwerda, Christian R, Sawhney, S., J. Brian De Souza, Quentin D. Bickle, Kaye, Paul M, De Souza, J.B.   +23 more
core   +1 more source