Results 101 to 110 of about 7,415 (242)
Severe malaria: what's new on the pathogenesis front? [PDF]
, 2016 Plasmodium falciparum causes the most severe and fatal form of malaria in humans with over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of severe falciparum malaria, is often fatal and represents a major public ...
Grau, Georges Emile Raymond +1 more
core +1 more source
Journal of Extracellular Vesicles, Volume 13, Issue 8, August 2024.Abstract Parasitic diseases have a significant impact on human and animal health, representing a major hazard to the public and causing economic and health damage worldwide. Extracellular vesicles (EVs) have long been recognized as diagnostic and therapeutic tools but are now also known to be implicated in the natural history of parasitic diseases and ...
Ana Acacia Sá Pinheiro +8 more
wiley +1 more source
Cytoadherence and severe malaria.
The Malaysian journal of medical sciences : MJMS, 2012 Malaria is a disease that causes enormous human morbidity and mortality. One feature of mature Plasmodium falciparum-infected erythrocytes leading to the development of severe malaria is thought to be cytoadherence and blockage of the microvasculature. Therefore, an understanding of mechanisms that mediate parasite adhesion leading to malaria pathology
Craig, Alister G. +2 more
openaire +1 more source
A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum–infected erythrocytes [PDF]
Blood, 2016 Key PointsPlasmodium falciparum–generated cytoadherent knobs on infected erythrocytes contain a spiral framework linked to the red cell cytoskeleton. The findings suggest a structural basis for transmission of shear forces in adhesion of infected cells.
Ioannis Vakonakis +9 more
openaire +5 more sources
Molecular mechanistic insights into the endothelial receptor mediated cytoadherence of Plasmodium falciparum-infected erythrocytes. [PDF]
PLoS ONE, 2011 Cytoadherence or sequestration is essential for the pathogenesis of the most virulent human malaria species, Plasmodium falciparum (P. falciparum). Similar to leukocyte-endothelium interaction in response to inflammation, cytoadherence of P.
Ang Li +8 more
doaj +1 more source
Modulation of cerebral malaria by curcumin as an adjunctive therapy [PDF]
, 2013 Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually.
Gowthamarajan, K. +2 more
core +1 more source
Evolutionary Applications, Volume 17, Issue 5, May 2024.Abstract Most malaria (Plasmodium spp.) parasite species undergo asexual replication synchronously within the red blood cells of their vertebrate host. Rhythmicity in this intraerythrocytic developmental cycle (IDC) enables parasites to maximise exploitation of the host and align transmission activities with the time of day that mosquito vectors blood ...
Alíz T. Y. Owolabi +2 more
wiley +1 more source
Biomolecules, 2020 In Trichomonas vaginalis (T. vaginalis), cyclophilins play a vital role in dislodging Myb proteins from the membrane compartment and leading them to nuclear translocation. We previously reported that TvCyP1 cyclophilin from T. vaginalis forms a dimer and
Sarita Aryal +6 more
doaj +1 more source
Expansion of Lysine-rich repeats in Plasmodium proteins generates novel localisation sequences that target the periphery of the host Erythrocyte [PDF]
, 2016 Repetitive low-complexity sequences, mostly assumed to have no function, are common in proteins that are exported by the malaria parasite into its host erythrocyte.
Davies, Heledd +2 more
core +1 more source
Cancer Medicine, Volume 13, Issue 6, March 2024.Abstract Background Pseudomyxoma peritonei (PMP) is a rare clinical malignant syndrome, and its rarity causes a lack of pathology research. This study aims to quantitatively analyze HE‐stained pathological images (PIs), and develop a new predictive model integrating digital pathological parameters with clinical information.
Ru Ma +5 more
wiley +1 more source