Results 101 to 110 of about 6,252 (195)

Potential of extracellular vesicles in the pathogenesis, diagnosis and therapy for parasitic diseases

Journal of Extracellular Vesicles, Volume 13, Issue 8, August 2024.
Abstract Parasitic diseases have a significant impact on human and animal health, representing a major hazard to the public and causing economic and health damage worldwide. Extracellular vesicles (EVs) have long been recognized as diagnostic and therapeutic tools but are now also known to be implicated in the natural history of parasitic diseases and ...
Ana Acacia Sá Pinheiro, Ana Claudia Torrecilhas, Bruno Solano de Freitas Souza, Fernanda Ferreira Cruz, Herbert Leonel de Matos Guedes, Tadeu Diniz Ramos, Miqueias Lopes‐Pacheco, Celso Caruso‐Neves, Patricia R. M. Rocco   +8 more
wiley   +1 more source

The role of ICAM-1 in Plasmodium falciparum cytoadherence

European Journal of Cell Biology, 2005
Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1) and its role in mediating the interaction between the parasitised red blood cell (PRBC) and the ...
Srabasti J, Chakravorty, Alister, Craig
openaire   +2 more sources

Plasmodium falciparum infection induces dynamic changes in the erythrocyte phospho-proteome [PDF]

, 2016
The phosphorylation status of red blood cell proteins is strongly altered during the infection by the malaria parasite Plasmodium falciparum. We identify the key phosphorylation events that occur in the erythrocyte membrane and cytoskeleton during ...
Bouyer, Guillaume, D. Phillips, Lee, Egee, Stephane, Langsley, Gordon, Lasonder, Edwin, Ramdani, Ghania, Reininger, Luc, Sharma, Vikram   +7 more
core   +4 more sources

Virulence is associated with daily rhythms in the within‐host replication of the malaria parasite Plasmodium chabaudi

Evolutionary Applications, Volume 17, Issue 5, May 2024.
Abstract Most malaria (Plasmodium spp.) parasite species undergo asexual replication synchronously within the red blood cells of their vertebrate host. Rhythmicity in this intraerythrocytic developmental cycle (IDC) enables parasites to maximise exploitation of the host and align transmission activities with the time of day that mosquito vectors blood ...
Alíz T. Y. Owolabi, Petra Schneider, Sarah E. Reece   +2 more
wiley   +1 more source

Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

Nature Communications, 2020
Extracellular vesicles (EVs) in plasma can affect pathogenesis of parasites, but details remain unclear. Here, Toda et al. characterize plasma-derived EVs from Plasmodium vivax patients and show that PvEVs are preferentially taken up by human spleen ...
Haruka Toda, Miriam Diaz-Varela, Joan Segui-Barber, Wanlapa Roobsoong, Barbara Baro, Susana Garcia-Silva, Alicia Galiano, Melisa Gualdrón-López, Anne C. G. Almeida, Marcelo A. M. Brito, Gisely Cardoso de Melo, Iris Aparici-Herraiz, Carlos Castro-Cavadía, Wuelton Marcelo Monteiro, Eva Borràs, Eduard Sabidó, Igor C. Almeida, Jakub Chojnacki, Javier Martinez-Picado, Maria Calvo, Pilar Armengol, Jaime Carmona-Fonseca, Maria Fernanda Yasnot, Ricardo Lauzurica, Antonio Marcilla, Hector Peinado, Mary R. Galinski, Marcus V. G. Lacerda, Jetsumon Sattabongkot, Carmen Fernandez-Becerra, Hernando A. del Portillo   +30 more
doaj   +1 more source

Structure and sequence analyses of Bacteroides proteins BVU_4064 and BF1687 reveal presence of two novel predominantly-beta domains, predicted to be involved in lipid and cell surface interactions. [PDF]

, 2015
BackgroundN-terminal domains of BVU_4064 and BF1687 proteins from Bacteroides vulgatus and Bacteroides fragilis respectively are members of the Pfam family PF12985 (DUF3869).
Aravind, L, Godzik, Adam, Kumar, Abhinav, Natarajan, Padmaja, Punta, Marco, Yeh, Andrew P   +5 more
core   +2 more sources

A nomogram prediction model of pseudomyxoma peritonei established based on new prognostic factors of HE stained pathological images analysis

Cancer Medicine, Volume 13, Issue 6, March 2024.
Abstract Background Pseudomyxoma peritonei (PMP) is a rare clinical malignant syndrome, and its rarity causes a lack of pathology research. This study aims to quantitatively analyze HE‐stained pathological images (PIs), and develop a new predictive model integrating digital pathological parameters with clinical information.
Ru Ma, Yan‐Dong Su, Feng‐Cai Yan, Yu‐Lin Lin, Ying Gao, Yan Li   +5 more
wiley   +1 more source

Cytoadherence‐dependent induction of inflammatory responses by Mycoplasma pneumoniae

Immunology, 2011
SummaryPathogenesis of Mycoplasma pneumoniae infection is considered to be in part attributed to excessive immune responses. Mycoplasma pneumoniae shows strong cytoadherence to host cells and this cytoadherence is thought to be involved in the progression of pneumonia.
Takashi, Shimizu, Yutaka, Kida, Koichi, Kuwano   +2 more
openaire   +3 more sources

Cytoadherence characteristics to endothelial receptors ICAM-1 and CD36 of Plasmodium falciparum populations from severe and uncomplicated malaria cases

Parasite, 2008
The adhesion of infected red blood cells (IRBCs) to the cell lining of microvasculature is thought to play a central role in the pathogenesis of severe malaria.
Cojean S., Jafari-Guemouri S., Le Bras J., Durand R.   +3 more
doaj   +1 more source

Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis. [PDF]

, 2015
Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection. Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeostasis ...
Ackerman, H, Alkaitis, MS, Billker, O, Casals-Pascual, C, Chertow, JH, Conway, DJ, Correa, S, Cunnington, AJ, Ebonyi, AO, Ikeda, AK, Jayasooriya, S, Nardone, G, Njie, M, Okebe, J, Walther, M   +14 more
core   +1 more source