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Identification of fibronectin as a receptor for bacterial cytoadherence
1994Publisher Summary This chapter discusses the identification of fibronectin as a receptor for bacterial cytoadherence. Studies on the associations between bacterial pathogens and certain host proteins likely resulted from serendipitous observations. Such was the case involving fibronectin and Staphylococcus aureus .
Michael W. Lehker +2 more
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Sticky rings: challenging the cytoadherence dogma
Trends in Parasitology, 2001The accumulation of red blood cells (RBCs) parasitized by Plasmodium falciparum in many organs, particularly the brain and placenta, is probably the most extensively studied phenomenon in the pathogenesis of falciparum malaria. Parasitized RBCs (PRBCs) sequester as a result of receptor–ligand interactions between surface molecules on PRBCs and vascular
James G. Beeson +2 more
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Multiple Host Receptors for Malaria Cytoadherence Protein
Parasitology Today, 2000Abstract Q. Chen et al. (2000) The semiconserved head structure of Plasmodium falciparum erythrocyte membrane protein 1 mediates binding to multiple independent host receptors. J. Exp. Med .
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Spleen modulation of cytoadherence properties of Plasmodium falciparum
Scandinavian Journal of Infectious Diseases, 2009Cytoadherence to CD36 and ICAM-1 and var gene expression of P. falciparum parasites from a splenectomized patient were studied. These parasites lacked cytoadherence and showed expression of a non-coding cDNA sequence. Hence the spleen's modulation of parasite cytoadherence by mechanisms that affect the parasite's surface antigen expression is suggested.
Shiroma M. Handunnetti +4 more
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Cerebral Malaria in Children: Clinical Implications of Cytoadherence
The American Journal of Tropical Medicine and Hygiene, 1990In endemic areas, most of the people who die from falciparum malaria are young children. Death is commonly preceded by coma (cerebral malaria). The possible role of cytoadherence in this clinical picture is considered.
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, 2014
Parasite derived surface antigen PfEMP1 is a virulence factor of the human malaria parasite. PfEMP1 variants have been implicated in the cytoadherence of P. falciparum infected erythrocytes (iRBC) to several binding receptors on host vascular endothelium.
S. Gemma +14 more
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Parasite derived surface antigen PfEMP1 is a virulence factor of the human malaria parasite. PfEMP1 variants have been implicated in the cytoadherence of P. falciparum infected erythrocytes (iRBC) to several binding receptors on host vascular endothelium.
S. Gemma +14 more
semanticscholar +1 more source
Knobs, knob proteins and cytoadherence in falciparum malaria
International Journal of Biochemistry, 19911. The sequestration of trophozoite and schizont infected erythrocytes (IRBC) in post-capillary venules of host internal organs causes most of the morbidity and mortality in falciparum malaria. It is a knob mediated cytoadherence phenomenon where knobs act as the focal junction between IRBC and host endothelial cell.
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Cytoadherence effects of serum on Ascaris suum infective larvae
Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale. A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie, 1983Dead and live Ascaris suum infective larvae were found to adhere to monolayer cultures of mouse peritoneal macrophages following incubation with normal rabbit serum (NRS) or with rabbit anti-A, suum (RAAS). Cell-larval binding was shown to be affected by the numbers of larvae added to cell monolayers and by incubation time.
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