Results 71 to 80 of about 7,415 (242)

Cytoadherence and sequestration in Plasmodium falciparum: defining the ties that bind

Microbes and Infection, 2003
Infected erythrocytes containing the more mature stages of the human malaria Plasmodium falciparum may adhere to endothelial cells and uninfected red cells. These phenomena, called sequestration and rosetting, respectively, are involved in both host pathogenesis and parasite survival.
Irwin W. Sherman, Shigetoshi Eda, Enrique Winograd   +2 more
openalex   +4 more sources

Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome

Journal of Immunology Research, 2019
The severity of Plasmodium falciparum malaria is associated with parasite cytoadherence, but there is limited knowledge about the effect of parasite cytoadherence in malaria-associated acute respiratory distress syndrome (ARDS).
Luana dos Santos Ortolan, Michelle Klein Sercundes, Gabriel Candido Moura, Thatyane de Castro Quirino, Daniela Debone, Douglas de Sousa Costa, Oscar Murillo, Claudio Romero Farias Marinho, Sabrina Epiphanio   +8 more
doaj   +1 more source

Identification of Plasmodium falciparum var1CSA and var2CSA domains that bind IgM natural antibodies [PDF]

, 2006
Malaria in pregnancy is responsible for maternal anaemia, low-birth-weight babies and infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental pathology by adhering to host receptors such as chondroitin sulphate A (CSA ...
Ahmed Raza, Atalay, Baruch, Baruch, Buffet, Chen, Chen, Chitnis, Cohen, Cooke, Craig, Creasey, Fagan, Flick, Fried, Gamain, Gamain, Gardner, Guyatt, J. Alexandra Rowe, Jean-Philippe Semblat, Kyes, Kyes, Langone, Lin, Mayor, Medina, Medina, Rowe, Rowe, Rowe, Salanti, Salanti, Scholander, Smith, Smith, Su, Sue A. Kyes   +37 more
core   +1 more source

Molecular mechanisms of cytoadherence in malaria

American Journal of Physiology-Cell Physiology, 1999
Microbial pathogens subvert host adhesion molecules to disseminate or to enter host cells to promote their own survival. One such subversion is the cytoadherence of Plasmodium falciparum-infected erythrocytes (IRBC) to vascular endothelium, which protects the parasite from being removed by the spleen.
May, H, White, N
openaire   +5 more sources

Clinical and molecular aspects of severe malaria

Anais da Academia Brasileira de Ciências, 2005
The erythrocytic cycle of Plasmodium falciparum presents a particularity in relation to other Plasmodium species that infect man. Mature trophozoites and schizonts are sequestered from the peripheral circulation due to adhesion of infected erythrocytes ...
Karin Kirchgatter, Hernando A. Del Portillo   +1 more
doaj   +1 more source

Recent advances in malaria genomics and epigenomics [PDF]

, 2016
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian, Power, B. Joanne, Waters, Andrew P.   +2 more
core   +1 more source

Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution [PDF]

, 2018
Although Plasmodium vivax is responsible for the majority of malaria infections outside Africa, little is known about its evolution and pathway to humans. Its closest genetic relative, P.
Arnathau, Céline, Boundenga, Larson, Durand, Patrick, Franzon, Blaise, Gilabert, Aude, Makanga, Boris, Moukodoum, Nancy D., Ngoubangoye, Barthélémy, Okouga, Alain-Prince, Ollomo, Benjamin, Otto, Thomas D., Paupy, Christophe, Prugnolle, Franck, Renaud, François, Rougeron, Virginie, Rutledge, Gavin G.   +15 more
core   +4 more sources

Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate [PDF]

Malaria Journal, 2011
Abstract Background The surface antigen Pf EMP-1 is a key virulence factor of the human malaria parasite implicated in the cytoadherence of Plasmodium falciparum infected erythrocytes to a range of receptors on host endothelium. Among these host receptors, binding to ICAM-1 is related to cerebral malaria. The majority
Alister Craig, Sandra Gemma, Pradeep R Patil, Pradeep R Patil, Pradeep R Patil, Giuseppe Campiani   +5 more
openaire   +7 more sources

Plasmodium falciparum infection induces dynamic changes in the erythrocyte phospho-proteome [PDF]

, 2016
The phosphorylation status of red blood cell proteins is strongly altered during the infection by the malaria parasite Plasmodium falciparum. We identify the key phosphorylation events that occur in the erythrocyte membrane and cytoskeleton during ...
Bouyer, Guillaume, D. Phillips, Lee, Egee, Stephane, Langsley, Gordon, Lasonder, Edwin, Ramdani, Ghania, Reininger, Luc, Sharma, Vikram   +7 more
core   +4 more sources

Optimization and inhibition of the adherent ability of Plasmodium falciparum-infected erythrocytes

Memorias do Instituto Oswaldo Cruz, 1992
The vast majority of the 1-2 million malaria associated deaths that occur each year are due to anemia and cerebral malaria (the attachment of erythrocytes containing mature forms of Plasmodium falciparum to the endothelial cells that line the vascular ...
Heidi Smith, Ian Crandall, Jacques Prudhomme, Irwin Sherman   +3 more
doaj   +1 more source